1,3,4-OXADIAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H2N2O
Molecular Weight	70.0501
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O1C=NN=C1

InChI

InChIKey=FKASFBLJDCHBNZ-UHFFFAOYSA-N

InChI=1S/C2H2N2O/c1-3-4-2-5-1/h1-2H

HIDE SMILES / InChI

Molecular Formula	C2H2N2O
Molecular Weight	70.0501
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Allosteric regulation of glycogen synthase kinase 3β: a theoretical study.	2010-12-28	21105670
Bromidotricarbon-yl[2-phenyl-5-(pyridin-2-yl-κN)-1,3,4-oxadiazole-κN]rhenium(I) dichloro-methane monosolvate.	2010-12-18	21522603
A two-photon excited luminescence of water-soluble rhodamine-platinum(II) complex: fluorescent probe specific for Hg2+ detection in live cell.	2010-12-15	21111188
Bromidotricarbon-yl[2-(pyridin-2-yl-κN)-5-p-tolyl-1,3,4-oxadiazole-κN]rhenium(I) dichloro-methane monosolvate.	2010-12-04	21522604
Synthesis, biological evaluation, and molecular docking studies of 2-chloropyridine derivatives possessing 1,3,4-oxadiazole moiety as potential antitumor agents.	2010-11-15	20947362
Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives.	2010-11	20828888
Design, synthesis and biological evaluation of 1,3,4-oxadiazole derivatives.	2010-11	20817328
Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid.	2010-08-15	20643545
New hyperbranched conjugated polymers containing hexaphenylbenzene and oxadiazole units: convenient synthesis and efficient deep blue emitters for PLEDs application.	2010-07-22	20590166
Efficient Electrochemical Synthesis, Antimicrobial and Antiinflammatory Activity of 2-amino-5-substituted- 1,3,4-oxadiazole Derivatives.	2010-07	21218056
QSAR study of substituted 1,3,4-oxadiazole naphthyridines as HIV-1 integrase inhibitors.	2010-07	20347187
A practical synthesis of 5-lipoxygenase inhibitor MK-0633.	2010-06-18	20486715
Novel one-pot, four-component condensation reaction: an efficient approach for the synthesis of 2,5-disubstituted 1,3,4-oxadiazole derivatives by a Ugi-4CR/aza-Wittig sequence.	2010-06-18	20481612
Synthesis of novel 1,3,4-oxadiazole derivatives as potential antimicrobial agents.	2010-06-08	20524426
Synthesis of a second generation chroman/catechol hybrids and evaluation of their activity in protecting neuronal cells from oxidative stress-induced cell death.	2010-06-01	20466554
4-Chloro-N-[3-methyl-1-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)but-yl]benzamide.	2010-05-19	21579462
Molecular logic gates and switches based on 1,3,4-oxadiazoles triggered by metal ions.	2010-05-17	20391441
Synthesis of some novel 2-substituted-5-[isopropylthiazole] clubbed 1,2,4-triazole and 1,3,4-oxadiazoles as potential antimicrobial and antitubercular agents.	2010-05	20149496
Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.	2010-05	20110137
Synthesis and anti-inflammatory evaluation of some condensed [4-(3,4-dimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide.	2010-04	20149488
Asymmetric total synthesis of vindoline.	2010-03-24	20187641
Total synthesis of (+)-fendleridine (aspidoalbidine) and (+)-1-acetylaspidoalbidine.	2010-03-10	20148585
Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety.	2010-03	20004043
Anti-HIV activity of new substituted 1,3,4-oxadiazole derivatives and their acyclic nucleoside analogues.	2010-02-18	20158144
A possible correlation between the correction of endothelial dysfunction and normalization of high blood pressure levels by 1,3,4-oxadiazole derivative, an L-type Ca2+ channel blocker in deoxycorticosterone acetate and N(G)-nitro-l-arginine hypertensive rats.	2010-01-27	19912999
Synthesis and characterization of organic dyes containing various donors and acceptors.	2010-01-22	20162019
The modulation of electronic and optical properties of OXD-X through introduction of the electron-withdrawing groups: a DFT study.	2010-01	19910229
Synthesis and antimicrobial activity of 3-(1,3,4-Oxadiazol-2-yl)quinazolin-4(3H)-ones.	2009-12-17	21179342
2-(4-tert-Butyl-phen-yl)-5-p-tolyl-1,3,4-oxadiazole.	2009-12-04	21580186
Vasorelaxant effect in rat aortic rings through calcium channel blockage: a preliminary in vitro assessment of a 1,3,4-oxadiazole derivative.	2009-10-30	19643099
2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.	2009-10-22	19775160
Design, synthesis and hypolipidemic activity of novel 2-(naphthalen-2-yloxy)propionic acid derivatives as desmethyl fibrate analogs.	2009-10	19450906
Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents.	2009-10	19423197
Design and synthesis of novel neuroprotective 1,2-dithiolane/chroman hybrids.	2009-09-01	19647438
5-[1-(3,4-Dichloro-phen-oxy)eth-yl]-1,3,4-oxadiazole-2(3H)-thione hemihydrate.	2009-08-08	21577496
Methylsulfonylpyrazolyl oxadiazoles and thiadiazoles as potent, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesity.	2009-08	21426091
A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases.	2009-08	19386397
Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties.	2009-06	19564146
(2S)-Methyl 2-(4-chloro-benzene-sulfon-amido)-4-(methyl-sulfan-yl)butanoate.	2009-05-20	21583200
(2S)-Methyl 2-(p-toluenesulfonamido)propanoate.	2009-05-14	21583158
Luminescent, liquid crystalline tris(N-salicylideneaniline)s: synthesis and characterization.	2009-04-17	19317428
Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors.	2009-03-05	19265512
N,N'-Diacetyl-N'-[(4-nitro-phen-oxy)acetyl]acetohydrazide.	2009-01-23	21581970
Synthesis and Biological Evaluation of beta-Aroylpropionic acid based 1,3,4-Oxadiazoles.	2009-01	20177461
N,N'-Dibenzyl-2,2'-[(1,3,4-oxadiazole-2,5-di-yl)bis-(o-phenyl-eneoxy)]diacet-amide.	2008-10-31	21581091
1-[2-(3,4-Dichloro-phen-yl)-5-(3,4,5-trimethoxy-phen-yl)-2,3-dihydro-1,3,4-oxadiazol-3-yl]ethanone.	2008-07-09	21203158
Ethyl 2-(5-phenyl-1,3,4-oxadiazol-2-ylsulfan-yl)acetate.	2008-03-20	21202126
N,N-Dimethyl-4-[5-(5-methyl-1-phenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl]aniline.	2008-01-04	21201385
Synthesis, Antimicrobial and Antiinflammatory Activity of 2,5-Disubstituted-1,3,4-oxadiazoles.	2008-01	20390080
N-Phenyl-N-{4-[5-(4-pyrid-yl)-1,3,4-oxadiazol-2-yl]phen-yl}aniline.	2007-12-12	21200808

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:19:17 GMT 2025` Edited by `admin` on `Mon Mar 31 21:19:17 GMT 2025`
Record UNII	20O2F20OUR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-122449

Preferred Name

English

1,3,4-OXADIAZOLE

Systematic Name

English

1,3,4-OXADIAZOLE [MI]

Common Name

English

1-OXA-3,4-DIAZACYCLOPENTADIENE

Systematic Name

English

Code System Code Type Description

WIKIPEDIA

1,3,4-Oxadiazole