OCTOXYNOL-1 is a nonionic surfactant that has a hydrophilic ethylene oxide chain and an aromatic hydrocarbon lipophilic or hydrophobic 4-(1,1,3,3-tetramethylbutyl)-phenyl group. OCTOXYNOL-1 is insoluble in water and soluble in common polar organic solvents. OCTOXYNOL-1 are being used in cosmetic products. Concentration of use data received from the cosmetics industry in 1999 and updated in 2001 indicate that the Octoxynols (their salts and organic acids included) are used in cosmetics at concentrations ranging from 0.0008% to 25%, and that most of the use concentrations are less than 5.0%. OCTOXYNOL-1 is a common environmental pollutant that displays weak estrogenic effects. OCTOXYNOL-1 has been shown to cause harm to the male reproductive system of vertebrates in particular among aquatic species where gonadal intersex, altered sex ratios, and reduced gonad size has been observed.