Details
Stereochemistry | ACHIRAL |
Molecular Formula | C25H31FN6O2.ClH |
Molecular Weight | 503.012 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCN1N=NN(CCN2CCC(CC2)(N(C(=O)CC)C3=C(F)C=CC=C3)C4=CC=CC=C4)C1=O
InChI
InChIKey=YMRJQYDWCFOMRR-UHFFFAOYSA-N
InChI=1S/C25H31FN6O2.ClH/c1-3-23(33)32(22-13-9-8-12-21(22)26)25(20-10-6-5-7-11-20)14-16-29(17-15-25)18-19-31-24(34)30(4-2)27-28-31;/h5-13H,3-4,14-19H2,1-2H3;1H
Molecular Formula | C25H31FN6O2 |
Molecular Weight | 466.551 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Trefentanil is a short-acting synthetic opioid of the piperidine class. The drug caused potent analgesia with the peak effect occurring 3 min after injection. There was no significant difference in analgesic potency of trefentanil and alfentanil as measured by tolerance to tibial pressure at 3 min. Trefentanil had a pharmacokinetic and pharmacodynamic profile similar to alfentanil, with a small extent of tissue distribution and a rapid blood/brain equilibration. Trefentanil caused significant respiratory depression at doses of 32 ug/kg and 64 ug/kg. It is a mu-opioid receptor agonist. Trefentanil produced naloxone reversible anti-nociception equi-efficacious to that of fentanyl.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
A-3665, a new short-acting opioid: a comparison with alfentanil. | 1993 Apr |
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Pharmacokinetic-pharmacodynamic relationships for opioids in balanced anaesthesia. | 1995 Oct |
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New opioid analgesics: an update. | 1997 Spring |
|
Mu opiate active substances trefentanil and naloxonazine: tritiation at high specific activity. | 2005 Aug |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:32:44 GMT 2023
by
admin
on
Fri Dec 15 15:32:44 GMT 2023
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Record UNII |
20742ZOB3G
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C241
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NCI_THESAURUS |
C67413
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admin on Fri Dec 15 15:32:44 GMT 2023 , Edited by admin on Fri Dec 15 15:32:44 GMT 2023
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DD-40
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DBSALT001793
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C152721
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DTXSID40152956
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60727
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CHEMBL84617
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20742ZOB3G
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120656-93-1
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admin on Fri Dec 15 15:32:44 GMT 2023 , Edited by admin on Fri Dec 15 15:32:44 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |