Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H20N2.2ClH |
| Molecular Weight | 265.222 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.C=C=CCNCCCCNCC=C=C
InChI
InChIKey=ITVRWVVFVHINOH-UHFFFAOYSA-N
InChI=1S/C12H20N2.2ClH/c1-3-5-9-13-11-7-8-12-14-10-6-4-2;;/h5-6,13-14H,1-2,7-12H2;2*1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C12H20N2 |
| Molecular Weight | 192.3006 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 2 |
| Optical Activity | NONE |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2105 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12458962 |
90.0 nM [Ki] |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis. | 2007-11 |
|
| Sensitization of human colon adenocarcinoma cells (LoVo) to reactive oxygen species by a lysosomotropic compound. | 2006-10 |
|
| Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. | 2006-10 |
|
| Cytotoxicity of the polyamine oxidase inactivator MDL 72527 to cancer cells: comparison with a saturated structural analogue. | 2005-12 |
|
| Inhibition of murine N1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL 72527. | 2005-01-14 |
|
| How important is the oxidative degradation of spermine?: minireview article. | 2004-07 |
|
| Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:08:57 GMT 2025
by
admin
on
Mon Mar 31 22:08:57 GMT 2025
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| Record UNII |
1YVR349GN4
|
| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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1YVR349GN4
Created by
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93565-01-6
Created by
admin on Mon Mar 31 22:08:57 GMT 2025 , Edited by admin on Mon Mar 31 22:08:57 GMT 2025
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3035046
Created by
admin on Mon Mar 31 22:08:57 GMT 2025 , Edited by admin on Mon Mar 31 22:08:57 GMT 2025
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