Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H32N3O10P.2Na.2H2O |
| Molecular Weight | 623.4981 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.O.[Na+].[Na+].CC(C)C[C@H](NP([O-])(=O)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O)C(=O)N[C@@H](CC2=CNC3=C2C=CC=C3)C([O-])=O
InChI
InChIKey=RUUVTTHDXFLIFU-HIKRQZGHSA-L
InChI=1S/C23H34N3O10P.2Na.2H2O/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15;;;;/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34);;;2*1H2/q;2*+1;;/p-2/t12-,16-,17-,18-,19+,20+,23-;;;;/m0..../s1
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | HO |
| Molecular Weight | 17.0073 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C23H34N3O10P |
| Molecular Weight | 543.5039 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 7 / 7 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries. | 2003-12-12 |
|
| Active amino acids of the Kell blood group protein and model of the ectodomain based on the structure of neutral endopeptidase 24.11. | 2003-10-15 |
|
| Aminopeptidases function as endocytic receptors in the trophotaenial placenta of the goodeid fish, Ameca splendens (Teleostei: Atheriniformes). | 2003-10-01 |
|
| Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia. | 2003-10 |
|
| CD10 is a key enzyme involved in the activation of tumor-activated peptide prodrug CPI-0004Na and novel analogues: implications for the design of novel peptide prodrugs for the therapy of CD10+ tumors. | 2003-09-01 |
|
| The role of endothelin converting enzyme inhibition during group B streptococcus-induced pulmonary hypertension in newborn piglets. | 2003-09 |
|
| Cerebral angiogenesis and expression of VEGF after subarachnoid hemorrhage (SAH) in rats. | 2003-08-15 |
|
| The effects of phosphoramidon on the expression of human endothelin-converting enzyme-1 (ECE-1) isoforms. | 2003-07 |
|
| [D-Val22]big ET-1[16-38] inhibits endothelin-converting enzyme activity: a promising concept in the prevention of cerebral vasospasm. | 2003-05 |
|
| Pathways and kinetics of deslorelin degradation in an airway epithelial cell line (Calu-1). | 2003-05 |
|
| Crucial role of extracellular signal-regulated kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts. | 2003-05 |
|
| Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway. | 2003-04 |
|
| Pseudomonas aeruginosa elastase degrades surfactant proteins A and D. | 2003-04 |
|
| Binding of a new bioactive 31-amino-acid endothelin-1 to an endothelin ET(B) or ET(B)-like receptor in porcine lungs. | 2003-03-28 |
|
| Peptidases prevent mu-opioid receptor internalization in dorsal horn neurons by endogenously released opioids. | 2003-03-01 |
|
| The formyl peptide N-formyl-methionyl-leucyl-phenylalanine downregulates the expression of FcgammaRs in interferon-gamma-activated monocytes/macrophages in vitro and in vivo. | 2003-03 |
|
| Identification and localization of a neprilysin-like activity that degrades tachykinin-related peptides in the brain of the cockroach, Leucophaea maderae, and locust, Locusta migratoria. | 2003-02-24 |
|
| Effect of endothelin-1 (1-31) on the renal resistance vessels. | 2003-02 |
|
| Effects of kinins on mammalian spermatozoa and the impact of peptidolytic enzymes. | 2003-02 |
|
| Role of tachykinins in the bronchoconstriction induced by HCl intraesophageal instillation in the rabbit. | 2003-01-24 |
|
| Action of three ectopeptidases on corticotropin-releasing factor: metabolism and functional aspects. | 2003-01 |
|
| Mechanical stretch-induced mitogen-activated protein kinase activation is mediated via angiotensin and endothelin systems in vascular smooth muscle cells. | 2002-12 |
|
| High-performance liquid chromatographic separation of renin-angiotensin system peptides and most of their metabolic fragments. | 2002-11-25 |
|
| Attenuation of ischemia/reperfusion induced MAP kinases by N-acetyl cysteine, sodium nitroprusside and phosphoramidon. | 2002-11 |
|
| Combination therapy of N-acetylcysteine, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney. | 2002-11 |
|
| Effect of endothelin-converting enzyme inhibitors on big endothelin-1 induced contraction in isolated rat basilar artery. | 2002-11 |
|
| Extracellular peptidases of imaginal discs of Drosophila melanogaster. | 2002-11 |
|
| The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum. | 2002-11 |
|
| Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease. | 2002-11 |
|
| Role of abnormal neutral endopeptidase-like activities in Hyp mouse bone cells in renal phosphate transport. | 2002-11 |
|
| [Met5]enkephalin-Arg-Gly-Leu-induced antinociception is greatly increased by peptidase inhibitors. | 2002-10-18 |
|
| Degradation of nociceptin (orphanin FQ) by mouse spinal cord synaptic membranes is triggered by endopeptidase-24.11: an in vitro and in vivo study. | 2002-10-15 |
|
| The increased proliferation of cultured neuroblastoma cells treated with vasoactive intestinal peptide is enhanced by simultaneous inhibition of neutral endopeptidase. | 2002-10-15 |
|
| Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages. | 2002-10-07 |
|
| Attenuation of renal ischemia/reperfusion injury by a triple drug combination therapy. | 2002-09-03 |
|
| Effect of quercetin on plasma extravasation in rat CNS and dura mater by ACE and NEP inhibition. | 2002-09 |
|
| Bradykinin potentiation by ACE inhibitors: a matter of metabolism. | 2002-09 |
|
| Induction of apoptosis and CD10/neutral endopeptidase expression by jaspamide in HL-60 line cells. | 2002-08 |
|
| Tachykinins and airway microvascular leakage induced by HCl intra-oesophageal instillation. | 2002-08 |
|
| Phosphoramidon treatment improves the consequences of chagasic heart disease in mice. | 2002-08 |
|
| Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a. | 2002-08 |
|
| Characterization of PgPepO, a bacterial homologue of endothelin-converting enzyme-1. | 2002-08 |
|
| Endothelin-converting enzyme activity in human cerebral circulation. | 2002-08 |
|
| Effect of glycerol on endothelium-derived factors in the vasculature of the rabbit kidney. | 2002-08 |
|
| Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation. | 2002-07 |
|
| Pressor and pulmonary responses to ET-1(1-31) in guinea-pigs. | 2002-07 |
|
| Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of Rho kinase constrictor pathway. | 2002-06 |
|
| Efficient transesterification of sucrose catalysed by the metalloprotease thermolysin in dimethylsulfoxide. | 2002-05-22 |
|
| Vascular endothelin converting enzyme-1 expression and activity is upregulated in clinical diabetes. | 2002 |
|
| Endothelin-converting enzyme activity in vascular smooth muscle preparations in vitro. | 2002 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:17:53 GMT 2025
by
admin
on
Mon Mar 31 22:17:53 GMT 2025
|
| Record UNII |
1Y1FE6YEU5
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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| Name | Type | Language | ||
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Common Name | English | ||
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Preferred Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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91617739
Created by
admin on Mon Mar 31 22:17:53 GMT 2025 , Edited by admin on Mon Mar 31 22:17:53 GMT 2025
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PRIMARY | |||
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1Y1FE6YEU5
Created by
admin on Mon Mar 31 22:17:53 GMT 2025 , Edited by admin on Mon Mar 31 22:17:53 GMT 2025
|
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