BENZOIC ACID, 4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS- (CPP-BIS) is a building block for polyanhydrides, which is a class of bioerodible polymer containing drug delivery applications. The polyanhydride copolymer system which currently enjoys the most widespread interest in its medical applications employs the monomers sebacic acid (SA) and CPP-BIS (Polifeprosan). Polifeprosan is a biodegradable copolymer used to control the release of carmustine in GLIADEL Wafer. GLIADEL Wafer is an implant for intracranial use, containing carmustine, a nitrosourea alkylating agent. GLIADEL Wafer is indicated in newly-diagnosed high-grade malignant glioma patients and in recurrent glioblastoma multiforme. Most common adverse reactions of GLIADEL Wafer are cerebral edema, asthenia, nausea, vomiting, constipation, wound healing abnormalities and depression.