SULFIRAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H20N2S3
Molecular Weight	264.474
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)C(=S)SC(=S)N(CC)CC

InChI

InChIKey=CTPKSRZFJSJGML-UHFFFAOYSA-N

InChI=1S/C10H20N2S3/c1-5-11(6-2)9(13)15-10(14)12(7-3)8-4/h5-8H2,1-4H3

HIDE SMILES / InChI

Molecular Formula	C10H20N2S3
Molecular Weight	264.474
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11988682 | https://www.ncbi.nlm.nih.gov/pubmed/7986203 | https://www.ncbi.nlm.nih.gov/pubmed/7177842

Sulfiram (also known as monosulfiram) is a sulfide derivative patented by L. Givaudan & Cie. S. A. as effective anti-parasitic medicine used for the treatment and prevention of scabies and other skin related problems like itching, skin irritation, and inflammation. Sulfiram is a very weak inhibitor of aldehyde dehydrogenase. Sulfiram is usually sold as a solution or medicated soap, sometimes in combination with benzyl benzoate. Sulfiram is now rarely used, but, as of 2015, is still available in Brazil, India, and South Africa.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Aldehyde dehydrogenase 8 Target ID: CHEMBL1935 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7905136	Inhibitor 8297

PubMed

Title	Date	PubMed
Allergic contact dermatitis from natural latex.	2001 Sep	11526517
[Profuse scabies: kinetic curves of parasitologic cure with an association of benzyl benzoate and sulfiram].	2002 Mar	11988682
Diagnosis and treatment of scabies in 2002: rapid diagnosis and proper management limit the risk of spread.	2002 Oct	12378748
Current treatments for scabies.	2003 Apr	12667233

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:43:02 UTC 2023` Edited by `admin` on `Fri Dec 15 15:43:02 UTC 2023`
Record UNII	1XHL4Q8P7Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SULFIRAM

Official Name

English

sulfiram [INN]

Common Name

English

SULFIRAM [MART.]

Common Name

English

TETMOSOL

Brand Name

English

SULFIRAME

Common Name

English

MONOSULFIRAM

Common Name

English

TETRAETHYLTHIODICARBONIC DIAMIDE ((((C(SUB 2)H(SUB 5))(SUB 2)N)C(S))(SUB 2)S)

Common Name

English

NSC-36731

Code

English

SULFIRAM [MI]

Common Name

English

Sulfiram [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1697