DIBROMPROPAMIDINE EMBONATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C23H16O6.C17H18Br2N4O2
Molecular Weight	858.528
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=N)C1=CC(Br)=C(OCCCOC2=C(Br)C=C(C=C2)C(N)=N)C=C1.OC(=O)C3=CC4=CC=CC=C4C(CC5=C(O)C(=CC6=CC=CC=C56)C(O)=O)=C3O

InChI

InChIKey=HFEFFNLWQCXXFD-UHFFFAOYSA-N

InChI=1S/C23H16O6.C17H18Br2N4O2/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;18-12-8-10(16(20)21)2-4-14(12)24-6-1-7-25-15-5-3-11(17(22)23)9-13(15)19/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2-5,8-9H,1,6-7H2,(H3,20,21)(H3,22,23)

HIDE SMILES / InChI

Molecular Formula	C17H18Br2N4O2
Molecular Weight	470.158
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C23H16O6
Molecular Weight	388.3695
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4358232
Curator's Comment: Description was created based on several sources, including http://www.goldeneyecare.co.uk/assets/Uploads/D52491-TP-GEOPL-UK-14v4-GoldenEye-Ointment-0.15.pdf | https://www.medicines.org.uk/emc/PIL.16474.latest.pdf

Dibrompropamidine isetionate is an antiseptic. Ointment containing dibrompropamidine isetionate is used to treat minor eye or eyelid infections, such as conjunctivitis and blepharitis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
http://purl.obolibrary.org/obo/OMIT_0002795 3 Target ID: http://purl.obolibrary.org/obo/OMIT_0002795 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7996383 \| https://www.ncbi.nlm.nih.gov/pubmed/8229701 \| https://www.ncbi.nlm.nih.gov/pubmed/4358232	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Eye infections 13 Sources: http://www.goldeneyecare.co.uk/assets/Uploads/D52491-TP-GEOPL-UK-14v4-GoldenEye-Ointment-0.15.pdf http://www.chemist.net/class/download.class.php?fileName=../sysimages/Brolene_Ointment_ds2355_1.pdf	Curative		Approved 8429	BROLENE Approved Use Dibrompropamidine isetionate is used for minor infections of the eye or eyelid.

PubMed

Title	Date	PubMed

Sample Use Guides

In Vivo Use Guide

Eye ointment containing dibrompropamidine isethionate 0.15% w/w to the affected eye once or twice each day for at least 2 days

Route of Administration: Topical

In Vitro Use Guide

Dibrompropamidine isethionate, 300 μg/ml in aqueous solution was rapidly bactericidal, killing 99.9% of E. coli 15 TAU cells in 3 min.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 13:44:07 GMT 2023` Edited by `admin` on `Sat Dec 16 13:44:07 GMT 2023`
Record UNII	1XH50DNH45
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIBROMPROPAMIDINE EMBONATE

Common Name

English

BENZENECARBOXIMIDAMIDE, 4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS(3-BROMO-, 4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHALENECARBOXYLATE) (1:1)

Systematic Name

English

EINECS 298-927-0

Code

English

2-NAPHTHALENECARBOXYLIC ACID, 4,4'-METHYLENEBIS(3-HYDROXY-, COMPD. WITH 4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS(3-BROMOBENZENECARBOXIMIDAMIDE) (1:1)

Systematic Name

English

Dibrompropamidine embonate [WHO-DD]

Common Name

English

Code System Code Type Description

CAS

93840-61-0

Created by admin on Sat Dec 16 13:44:07 GMT 2023 , Edited by admin on Sat Dec 16 13:44:07 GMT 2023

PRIMARY

EPA CompTox

DTXSID70917595

Created by admin on Sat Dec 16 13:44:07 GMT 2023 , Edited by admin on Sat Dec 16 13:44:07 GMT 2023

PRIMARY

PUBCHEM

56843770

Created by admin on Sat Dec 16 13:44:07 GMT 2023 , Edited by admin on Sat Dec 16 13:44:07 GMT 2023

PRIMARY

FDA UNII

1XH50DNH45

Created by admin on Sat Dec 16 13:44:07 GMT 2023 , Edited by admin on Sat Dec 16 13:44:07 GMT 2023

PRIMARY

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/4358232Curator's Comment: Description was created based on several sources, including http://www.goldeneyecare.co.uk/assets/Uploads/D52491-TP-GEOPL-UK-14v4-GoldenEye-Ointment-0.15.pdf | https://www.medicines.org.uk/emc/PIL.16474.latest.pdf

Approval Year

Targets

Conditions

Approved Use

PubMed

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4358232
Curator's Comment: Description was created based on several sources, including http://www.goldeneyecare.co.uk/assets/Uploads/D52491-TP-GEOPL-UK-14v4-GoldenEye-Ointment-0.15.pdf | https://www.medicines.org.uk/emc/PIL.16474.latest.pdf