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Details

Stereochemistry ACHIRAL
Molecular Formula C23H16O6.C17H18Br2N4O2
Molecular Weight 858.528
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIBROMPROPAMIDINE EMBONATE

SMILES

NC(=N)C1=CC=C(OCCCOC2=CC=C(C=C2Br)C(N)=N)C(Br)=C1.OC(=O)C3=CC4=CC=CC=C4C(CC5=C6C=CC=CC6=CC(C(O)=O)=C5O)=C3O

InChI

InChIKey=HFEFFNLWQCXXFD-UHFFFAOYSA-N
InChI=1S/C23H16O6.C17H18Br2N4O2/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;18-12-8-10(16(20)21)2-4-14(12)24-6-1-7-25-15-5-3-11(17(22)23)9-13(15)19/h1-10,24-25H,11H2,(H,26,27)(H,28,29);2-5,8-9H,1,6-7H2,(H3,20,21)(H3,22,23)

HIDE SMILES / InChI

Molecular Formula C17H18Br2N4O2
Molecular Weight 470.158
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C23H16O6
Molecular Weight 388.3695
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including http://www.goldeneyecare.co.uk/assets/Uploads/D52491-TP-GEOPL-UK-14v4-GoldenEye-Ointment-0.15.pdf | https://www.medicines.org.uk/emc/PIL.16474.latest.pdf

Dibrompropamidine isetionate is an antiseptic. Ointment containing dibrompropamidine isetionate is used to treat minor eye or eyelid infections, such as conjunctivitis and blepharitis.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
BROLENE

Approved Use

Dibrompropamidine isetionate is used for minor infections of the eye or eyelid.
PubMed

PubMed

TitleDatePubMed
Cosmetic contact lens-related Acanthamoeba keratitis.
2009-05
[When the treatment is the problem].
2009-02-12
[Graze with unusual progress].
2009-02-12
Good visual outcome after prompt treatment of acanthamoeba keratitis associated with overnight orthokeratology lens wear.
2007-11
Acanthamoeba keratitis: 2007: a train wreck in slow motion.
2007-09
In vitro effect of diamidines on intracellular polyamines of Acanthamoeba polyphaga.
2001
Studies on the mode of action of dibromopropamidine.
1973-06-01

Sample Use Guides

Eye ointment containing dibrompropamidine isethionate 0.15% w/w to the affected eye once or twice each day for at least 2 days
Route of Administration: Topical
In Vitro Use Guide
Dibrompropamidine isethionate, 300 μg/ml in aqueous solution was rapidly bactericidal, killing 99.9% of E. coli 15 TAU cells in 3 min.
Substance Class Chemical
Created
by admin
on Tue Apr 01 21:11:42 GMT 2025
Edited
by admin
on Tue Apr 01 21:11:42 GMT 2025
Record UNII
1XH50DNH45
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EINECS 298-927-0
Preferred Name English
DIBROMPROPAMIDINE EMBONATE
Common Name English
BENZENECARBOXIMIDAMIDE, 4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS(3-BROMO-, 4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHALENECARBOXYLATE) (1:1)
Systematic Name English
2-NAPHTHALENECARBOXYLIC ACID, 4,4'-METHYLENEBIS(3-HYDROXY-, COMPD. WITH 4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS(3-BROMOBENZENECARBOXIMIDAMIDE) (1:1)
Systematic Name English
Dibrompropamidine embonate [WHO-DD]
Common Name English
Code System Code Type Description
CAS
93840-61-0
Created by admin on Tue Apr 01 21:11:42 GMT 2025 , Edited by admin on Tue Apr 01 21:11:42 GMT 2025
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EPA CompTox
DTXSID70917595
Created by admin on Tue Apr 01 21:11:42 GMT 2025 , Edited by admin on Tue Apr 01 21:11:42 GMT 2025
PRIMARY
PUBCHEM
56843770
Created by admin on Tue Apr 01 21:11:42 GMT 2025 , Edited by admin on Tue Apr 01 21:11:42 GMT 2025
PRIMARY
FDA UNII
1XH50DNH45
Created by admin on Tue Apr 01 21:11:42 GMT 2025 , Edited by admin on Tue Apr 01 21:11:42 GMT 2025
PRIMARY