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Details

Stereochemistry ACHIRAL
Molecular Formula F6Si.2H4N
Molecular Weight 178.1528
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMMONIUM HEXAFLUOROSILICATE

SMILES

[NH4+].[NH4+].F[Si--](F)(F)(F)(F)F

InChI

InChIKey=ITHIMUMYFVCXSL-UHFFFAOYSA-P
InChI=1S/F6Si.2H3N/c1-7(2,3,4,5)6;;/h;2*1H3/q-2;;/p+2

HIDE SMILES / InChI

Molecular Formula F6Si
Molecular Weight 142.0759
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula H3N
Molecular Weight 17.0305
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Ammonium hexafluorosilicate is a white crystalline solid. Corrodes aluminum. Used as a disinfectant, in etching glass, metal casting, and electroplating. Ammonium hexafluorosilicate is useful for the treatment of dentin hypersensitivity, since ammonium hexafluorosilicate induced calcium phosphate precipitation from the saliva; therefore, it has a continuous effect on dentin tubules occlusion under a simulated oral environment. Ammonium hexafluorosilicate has been applied to arrest caries without discoloration. The major use of sodium hexafluorosilicate and fluorosilicic acid is as fluoridation agents for drinking water. Sodium hexafluorosilicate has also been used for caries control as part of asilicophosphate cement, an acidic gel in combination with monocalcium phosphate monohydrate,and a two-solution fluoride mouth rinse. Both chemicals are also used as a chemical intermediate (raw material) for aluminum trifluoride, cryolite (Na3AlF6), silicon tetrafluoride,and other fluorosilicates and have found applications in commercial laundry. Other applications for sodium hexafluorosilicate include its use in enamels/enamel frits for china and porcelain, in opalescent glass, metallurgy (aluminum and beryllium), glue, ore flotation, leather and wood preservatives, and in insecticides and rodenticides. It has been used in the manufacture of pure silicon, as a gelling agent in the production of molded latex foam, and as afluorinating agent in organic synthesis to convert organodichlorophosphorus compounds to the corresponding organodifluorophosphorus compound. In veterinary practice, external applicationof sodium hexafluorosilicate combats lice and mosquitoes on cattle, sheep, swine, and poultry, and oral administration combats roundworms and possibly whipworms in swine and prevents dental caries in rats. Apparently, all pesticidal products had their registrations cancelled or they were discontinued by the early 1990s

Approval Year

PubMed

PubMed

TitleDatePubMed
Ammonium hexafluorosilicate elicits calcium phosphate precipitation and shows continuous dentin tubule occlusion.
2008 Feb
Cytotoxicity of ammonium hexafluorosilicate on human gingival fibroblasts.
2013 Dec
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: In mice, an oral LD50 of 70 mg/kg (0.37 mmol/kg) for sodium hexafluorosilicate was reported. In rats, oral LD50 values of 125 and 430 mg/kg (0.665 and 2.29 mmol/kg, respectively) were calculated.
A probable oral lethal dose of 50-5000 mg/kg, classified as very toxic, has been reported for doses between 1 teaspoon and 1 ounce for a 150-pound (70-kg) person; a probable oral lethal dose of 5-50 mg/kg, classified as extremely toxic, has been reported for doses between 7 drops and 1 teaspoon for the same individual.
Route of Administration: Oral
The purpose of the study was to investigate the cytotoxicity of Ammonium hexafluorosilicate (SiF) on human gingival fibroblasts (hGFs) under different dosages (0.001%, 0.01%, 0.1%, and 1%) and treatment durations (1, 5, 10, and 30 min). MTT assay showed that there was significantly lower number of viable cells when the hGFs were treated with 0.01% (10min), 0.1% (10 and 30 min) and 1% (5, 10, and 30min) SiF than the control group (p<0.05). MMP decreased and GSH depletion increased dramatically along with higher concentrations (0.1% and 1% SiF) and prolonged times (10 and 30 min). DNA synthesis [S (%)] of cells treated with 0.1% and 1% SiF (5, 10, and 30min) was significantly lower than the control group (p<0.05). So exposure to up to 0.01% SiF for less than 5min causes low or no cytotoxicity in vitro.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:08:26 GMT 2023
Edited
by admin
on Fri Dec 15 15:08:26 GMT 2023
Record UNII
1X545W620G
Record Status Validated (UNII)
Record Version
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Name Type Language
AMMONIUM HEXAFLUOROSILICATE
MI  
Common Name English
AMMONIUM SILICOFLUORIDE [HSDB]
Common Name English
SILICATE(2-), HEXAFLUORO-, AMMONIUM (1:2)
Common Name English
NSC-310005
Code English
AMMONIUM FLUOSILICATE
Common Name English
SILICATE(2-), HEXAFLUORO-, DIAMMONIUM
Common Name English
DIAMMONIUM HEXAFLUOROSILICATE
Common Name English
DIAMMONIUM SILICON HEXAFLUORIDE
Systematic Name English
DIAMMONIUM HEXAFLUOROSILICATE(2-)
Common Name English
AMMONIUM SILICOFLUORIDE
HSDB   VANDF  
Common Name English
HEXAFLUOROSILICATE(2-) AMMONIUM (1:2)
Common Name English
AMMONIUM SILICOFLUORIDE [VANDF]
Common Name English
AMMONIUM HEXAFLUOROSILICATE [MI]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 75301
Created by admin on Fri Dec 15 15:08:26 GMT 2023 , Edited by admin on Fri Dec 15 15:08:26 GMT 2023
Code System Code Type Description
HSDB
472
Created by admin on Fri Dec 15 15:08:26 GMT 2023 , Edited by admin on Fri Dec 15 15:08:26 GMT 2023
PRIMARY
RXCUI
314494
Created by admin on Fri Dec 15 15:08:26 GMT 2023 , Edited by admin on Fri Dec 15 15:08:26 GMT 2023
PRIMARY RxNorm
PUBCHEM
28145
Created by admin on Fri Dec 15 15:08:26 GMT 2023 , Edited by admin on Fri Dec 15 15:08:26 GMT 2023
PRIMARY
EPA CompTox
DTXSID6047076
Created by admin on Fri Dec 15 15:08:26 GMT 2023 , Edited by admin on Fri Dec 15 15:08:26 GMT 2023
PRIMARY
FDA UNII
1X545W620G
Created by admin on Fri Dec 15 15:08:26 GMT 2023 , Edited by admin on Fri Dec 15 15:08:26 GMT 2023
PRIMARY
NSC
310005
Created by admin on Fri Dec 15 15:08:26 GMT 2023 , Edited by admin on Fri Dec 15 15:08:26 GMT 2023
PRIMARY
MERCK INDEX
m1794
Created by admin on Fri Dec 15 15:08:26 GMT 2023 , Edited by admin on Fri Dec 15 15:08:26 GMT 2023
PRIMARY Merck Index
CAS
16919-19-0
Created by admin on Fri Dec 15 15:08:26 GMT 2023 , Edited by admin on Fri Dec 15 15:08:26 GMT 2023
PRIMARY
WIKIPEDIA
Ammonium fluorosilicate
Created by admin on Fri Dec 15 15:08:26 GMT 2023 , Edited by admin on Fri Dec 15 15:08:26 GMT 2023
PRIMARY
ECHA (EC/EINECS)
240-968-3
Created by admin on Fri Dec 15 15:08:26 GMT 2023 , Edited by admin on Fri Dec 15 15:08:26 GMT 2023
PRIMARY