TAS-103

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H19N3O2.2ClH
Molecular Weight	406.306
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TAS-103

Structure Search

SMILES

Cl.Cl.CN(C)CCNC1=C2C(=O)C3=CC=CC=C3C2=C4C=CC(O)=CC4=N1

InChI

InChIKey=HAYAYGFVSIWSGQ-UHFFFAOYSA-N

InChI=1S/C20H19N3O2.2ClH/c1-23(2)10-9-21-20-18-17(13-5-3-4-6-14(13)19(18)25)15-8-7-12(24)11-16(15)22-20;;/h3-8,11,24H,9-10H2,1-2H3,(H,21,22);2*1H

HIDE SMILES / InChI

Molecular Formula	C20H19N3O2
Molecular Weight	333.3838
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
DNA topoisomerase I 59 Target ID: CHEMBL1781 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10100595	Inhibitor 8297		2.0 µM [IC50]
DNA topoisomerase II 66 Target ID: CHEMBL2094255 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10100595	Inhibitor 8297		6.5 µM [IC50]

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:33:11 GMT 2023` Edited by `admin` on `Fri Dec 15 15:33:11 GMT 2023`
Record UNII	1X260YUP2P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TAS-103

Common Name

English

BMS-247615

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1748

Created by admin on Fri Dec 15 15:33:11 GMT 2023 , Edited by admin on Fri Dec 15 15:33:11 GMT 2023

Code System Code Type Description

CAS

174634-09-4

Created by admin on Fri Dec 15 15:33:11 GMT 2023 , Edited by admin on Fri Dec 15 15:33:11 GMT 2023

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NCI_THESAURUS

C1733

Created by admin on Fri Dec 15 15:33:11 GMT 2023 , Edited by admin on Fri Dec 15 15:33:11 GMT 2023

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NCIT

FDA UNII

1X260YUP2P

Created by admin on Fri Dec 15 15:33:11 GMT 2023 , Edited by admin on Fri Dec 15 15:33:11 GMT 2023

PRIMARY

EPA CompTox

DTXSID20938538

Created by admin on Fri Dec 15 15:33:11 GMT 2023 , Edited by admin on Fri Dec 15 15:33:11 GMT 2023

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PUBCHEM

135413532

Created by admin on Fri Dec 15 15:33:11 GMT 2023 , Edited by admin on Fri Dec 15 15:33:11 GMT 2023

PRIMARY

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