KMUP-1

CN1C2=C(N(CCN3CCN(CC3)C4=CC=CC=C4Cl)C=N2)C(=O)N(C)C1=O

InChIKey=NIDVDYQCGWISJZ-UHFFFAOYSA-N

InChI=1S/C19H23ClN6O2/c1-22-17-16(18(27)23(2)19(22)28)26(13-21-17)12-9-24-7-10-25(11-8-24)15-6-4-3-5-14(15)20/h3-6,13H,7-12H2,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumour cells.	2015-11	26276211
KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel.	2010-05-08	20303989
KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: roles of PKG, PI3K/Akt and Bcl-2/Bax pathways.	2010-01-31	19962417
cGMP-enhancing- and alpha1A/alpha1D-adrenoceptor blockade-derived inhibition of Rho-kinase by KMUP-1 provides optimal prostate relaxation and epithelial cell anti-proliferation efficacy.	2007-09-15	17639498
Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G.	2006-09	16754782
KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels.	2004-08	15237094
KMUP-1 relaxes rabbit corpus cavernosum smooth muscle in vitro and in vivo: involvement of cyclic GMP and K(+) channels.	2002-03	11877322
A xanthine-based KMUP-1 with cyclic GMP enhancing and K(+) channels opening activities in rat aortic smooth muscle.	2001-09	11564644

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:27:20 GMT 2025` Edited by `admin` on `Mon Mar 31 23:27:20 GMT 2025`
Record UNII	1X0H7WEC5D
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

1H-PURINE-2,6-DIONE, 7-(2-(4-(2-CHLOROPHENYL)-1-PIPERAZINYL)ETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-

Preferred Name

English

KMUP-1

Common Name

English

7-(2-(4-(2-CHLOROPHENYL)PIPERAZINYL)ETHYL)-1,3-DIMETHYLXANTHINE

Systematic Name

English

Code System Code Type Description

FDA UNII

1X0H7WEC5D