KMUP-1

CN1C2=C(N(CCN3CCN(CC3)C4=CC=CC=C4Cl)C=N2)C(=O)N(C)C1=O

InChIKey=NIDVDYQCGWISJZ-UHFFFAOYSA-N

InChI=1S/C19H23ClN6O2/c1-22-17-16(18(27)23(2)19(22)28)26(13-21-17)12-9-24-7-10-25(11-8-24)15-6-4-3-5-14(15)20/h3-6,13H,7-12H2,1-2H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: roles of PKG, PI3K/Akt and Bcl-2/Bax pathways.	2010 Jan 31	19962417
KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel.	2010 May 8	20303989
Actions of KMUP-1, a xanthine and piperazine derivative, on voltage-gated Na(+) and Ca(2+) -activated K(+) currents in GH3 pituitary tumour cells.	2015 Nov	26276211

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:48:43 GMT 2023` Edited by `admin` on `Sat Dec 16 10:48:43 GMT 2023`
Record UNII	1X0H7WEC5D
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

KMUP-1

Common Name

English

1H-PURINE-2,6-DIONE, 7-(2-(4-(2-CHLOROPHENYL)-1-PIPERAZINYL)ETHYL)-3,7-DIHYDRO-1,3-DIMETHYL-

Systematic Name

English

7-(2-(4-(2-CHLOROPHENYL)PIPERAZINYL)ETHYL)-1,3-DIMETHYLXANTHINE

Systematic Name

English

Code System Code Type Description

FDA UNII

1X0H7WEC5D