RIVENPROST

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H34O6S
Molecular Weight	450.588
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COCC1=CC=CC(C[C@H](O)\C=C\[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)OC)=C1

InChI

InChIKey=FBQUXLIJKPWCAO-AZIFJQEOSA-N

InChI=1S/C24H34O6S/c1-29-16-18-6-3-5-17(13-18)14-19(25)8-9-20-21(23(27)15-22(20)26)10-12-31-11-4-7-24(28)30-2/h3,5-6,8-9,13,19-22,25-26H,4,7,10-12,14-16H2,1-2H3/b9-8+/t19-,20-,21-,22-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C24H34O6S
Molecular Weight	450.588
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20969852 | https://www.ncbi.nlm.nih.gov/pubmed/16581323 | https://www.caymanchem.com/product/13618 | https://clinicaltrials.gov/ct2/show/NCT00296556

Rivenprost (ONO-4819) is a potent and selective EP4 receptor agonist. This compound can increase bone formation by stimulating osteoblast differentiation and function, possibly by modulating mesenchymal cell differentiation. Rivenprost has also been studied for its potential to prevent bone loss (in osteoporosis) and stabilize bone implants. Combined with risedronate, rivenprost may be an effective treatment for osteoporosis. A phase II study evaluating rivenprost in ulcerative colitis was terminated in 2009.

Approval Year

PubMed

Title	Date	PubMed
Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation.	2002 Apr 2	11917107

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:37:58 GMT 2023` Edited by `admin` on `Sat Dec 16 17:37:58 GMT 2023`
Record UNII	1WBO45T413
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RIVENPROST

Official Name

English

ONO-4819

Code

English

METHYL 4-((2-((1R,2R,3R)-3-HYDROXY-2-((1E,3S)-3-HYDROXY-4-(3-(METHOXYMETHYL)PHENYL)BUT-1-EN-1-YL)-5-OXOCYCLOPENTYL)ETHYL)SULFANYL)BUTANOATE

Systematic Name

English

rivenprost [INN]

Common Name

English

(-)-ONO-4819

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C78568