SODIUM PIDOLATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C5H6NO3.Na
Molecular Weight	151.0958
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[O-]C(=O)[C@@H]1CCC(=O)N1

InChI

InChIKey=CRPCXAMJWCDHFM-DFWYDOINSA-M

InChI=1S/C5H7NO3.Na/c7-4-2-1-3(6-4)5(8)9;/h3H,1-2H2,(H,6,7)(H,8,9);/q;+1/p-1/t3-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C5H6NO3
Molecular Weight	128.106
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.currentscience.ac.in/Volumes/102/02/0288.pdfhttps://www.drugs.com/otc/121041/cleansing-foaming-gel-acne-pro-skin.html | https://www.ncbi.nlm.nih.gov/pubmed/25727335 | https://www.ncbi.nlm.nih.gov/pubmed/21834944 | https://www.ulprospector.com/en/na/PersonalCare/Detail/6637/223524/EcoCare-Zinclean | http://www.scalp-health.com/zinc-pca.htm
Curator's Comment: description was created based on several sources, including http://www.cir-safety.org/sites/default/files/pca.pdf

Zinc Pidolate (Zinc PCA) is a topical skin product with purifying, astingent, anti-inflammatory, antiseptic activity. It has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. Zinc Pidolate has also being shown to be effective against halitosis. Zinc PCA prevents the UV-induced MMP-1 production in vitro by suppressing the activation of AP-1. Zinc PCA was also able to enhance type I collagen synthesis in NHDFs, by increasing the expression of the mRNA encoding the ascorbic acid transporter SVCT2 in non-UV irradiated NHDFs, which suggests its promising effect against not only photoaged skin but also for the simple atrophic change of intrinsic skin ageing. Zinc PCA is able to suppress sebum secretion by inhibiting 5-α reductase in hyperseborrhea, to suppress body odor by forming zinc salts with short-chain fatty acids, to suppress wrinkles by inhibiting AP-1 to and inhibit bacterial growth including acne related Propionibacterium acnes.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium-dependent vitamin C transporter 2 5 Target ID: CHEMBL3271 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21834944	Activator 1430
Collagen alpha-1(I) chain 11 Target ID: P02452\|\|\|Q15176\|\|\|Q9UML6 Gene ID: 1277.0 Gene Symbol: COL1A1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21834944	Activator 1430
Transcription factor AP1 6 Target ID: CHEMBL2111421 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21834944	Activator 1430
Propionibacterium acnes 6 Target ID: CHEMBL612639 Sources: http://www.in-cosmetics.com/__novadocuments/4317 \| https://www.ulprospector.com/en/na/PersonalCare/Detail/6637/223524/EcoCare-Zinclean	Inhibitor 8297
Steroid 5-alpha-reductase 15 Target ID: CHEMBL2363075 Sources: https://www.ulprospector.com/en/na/PersonalCare/Detail/6637/223524/EcoCare-Zinclean \| www.google.com/patents/US20090203628 \| http://www.in-cosmetics.com/__novadocuments/4317	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Acne 98 Sources: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=cab1d71c-e017-4ff3-853b-b0e47dc1ee79&type=display http://www.solabia.com/Produto_7,1/Cosmetics/Zincidone.html http://www.scalp-health.com/zinc-pca.htm	Preventing	Approved 8429	CLEANSING FOAMING GEL ACNE PRO SKIN- zinc pidolate gel Approved Use Lange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne. Launch Date 2012
Halitosis 6 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25727335	Primary	Phase I 428	Unknown Approved Use Unknown
Seborrhea 11 Sources: http://www.in-cosmetics.com/__novadocuments/4317 http://www.scalp-health.com/zinc-pca.htm http://www.solabia.com/Produto_7,1/Cosmetics/Zincidone.html http://cosmetics.specialchem.com/product/i-ecochem-ecocare-zinclean	Primary	Approved 8429	EcoCare™ Zinclean Approved Use Use in anti-dandruff shampoos
Dry skin 6 Sources: http://www.cir-safety.org/sites/default/files/pca.pdf	Primary	Approved 8429	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Human seminal relaxin is a product of the same gene as human luteal relaxin.	1992 May	1572287
Fast analysis of water samples for detection of anions by capillary zone electrophoresis.	2001	11545352
A simultaneous assay method for L-glutamate and L-pyroglutamate contents in soy sauce using a 5-oxoprolinase (without ATP hydrolyzing activity).	2001 Feb	11302195
Inhibition of a model protease--pyroglutamate aminopeptidase by a natural oligosaccharide gum from Hakea gibbosa.	2001 Jan 16	11165074
Massive 5-oxoprolinuria with normal 5-oxoprolinase and glutathione synthetase activities.	2001 Jun	11486906
Stability and CTL activity of N-terminal glutamic acid containing peptides.	2001 Jun	11437956
Characterization of cigar tobaccos by gas chromatographic/mass spectrometric analysis of nonvolatile organic acids: application to the authentication of Cuban cigars.	2001 Mar	11312824
The mechanism of aubstrate eecognition of pyroglutamyl-peptidase I from Bacillus amyloliquefaciens as determined by X-ray crystallography and site-directed mutagenesis.	2001 May 25	11359794
Expression and prognostic significance of lysozyme in male breast cancer.	2002	12473177
Continuous spectrometric assays for glutaminyl cyclase activity.	2002 Apr 1	11906150
Spectrophotometric assays for L-lysine alpha-oxidase and gamma-glutamylamine cyclotransferase.	2002 Apr 15	11950211
CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV.	2002 Apr 2	11927537
Generation of amyloid beta peptide with pyroglutamate at position 3 in primary cortical neurons.	2002 Jul 12	12098492
Allatostatins of the tiger prawn, Penaeus monodon (Crustacea: Penaeidea).	2002 Jun	12126730
Pseudopeptide foldamers: the homo-oligomers of pyroglutamic acid.	2002 Jun 3	12180330
Fluorometric assay using naphthylamide substrates for assessing novel venom peptidase activities.	2002 Nov	12419513
Synthesis and preliminary evaluation of trans-3,4-conformationally-restricted glutamate and pyroglutamate analogues as novel EAAT2 inhibitors.	2002 Nov 4	12372536
Methacrylate derivatives incorporating pyroglutamic acid.	2002 Nov-Dec	12425681
Production of pyroglutamic acid by thermophilic lactic acid bacteria in hard-cooked mini-cheeses.	2002 Oct	12416800
Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity.	2002 Sep 3	12196024
Stereoselective synthesis of dipeptide beta-turn mimetics: 7-benzyl and 8-phenyl substituted azabicyclo[4.3.0]nonane amino acid esters.	2002 Sep 6	12201753
Characterizing degradation products of peptides containing N-terminal Cys residues by (off-line high-performance liquid chromatography)/matrix-assisted laser desorption/ionization quadrupole time-of-flight measurements.	2003	14608624
Determination of the post-translational modifications of salivary acidic proline-rich proteins.	2003 Apr	15621862
Characterization and sequence of tomato 2S seed albumin: a storage protein with sequence similarities to the fruit lectin.	2003 Apr	12687365
Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization.	2003 Aug 15	12737624
Pressure/temperature combined treatments of precursors yield hormone-like peptides with pyroglutamate at the N terminus.	2003 Dec 31	14690402
Isolation and identification of indigestible pyroglutamyl peptides in an enzymatic hydrolysate of wheat gluten prepared on an industrial scale.	2003 Jan 1	12502378
[Neuroprotective properties of pyroglutamic acid in combination with pyrrolidone].	2003 Jan-Feb	12683075
2,5-Disubstituted pyrrolidines: versatile regioselective and diastereoselective synthesis by enamine reduction and subsequent alkylation.	2003 Jun 7	12945761
Reinvestigation of the proposed folding and self-association of the Neuropeptide Head Activator.	2003 Mar	12592026
Proinsulin C-peptide and its C-terminal pentapeptide: degradation in human serum and Schiff base formation with subsequent CO2 incorporation.	2003 May	12827290
Origin of diastereoselection in the hydrosilylation of chiral N-acyliminium intermediates derived from pyroglutamic acid.	2004 Apr 26	15114576
Expression, purification, and characterization of avian Thy-1 from Lec1 mammalian and Tn5 insect cells.	2004 Feb	14711516
N-acetylation of the glutamate residue of intact glutathione conjugates in rats: a novel pathway for the metabolic processing of thiol adducts of xenobiotics.	2004 Jan	14709619
Chemical characterization of a lambda I amyloid protein isolated from formalin-fixed and paraffin-embedded tissue sections.	2004 Mar	15185499
Unexplained metabolic acidosis in critically ill patients: the role of pyroglutamic acid.	2004 Mar	14685659
Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions.	2004 Sep	15471563
Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).	2004 Sep	15183349
Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells.	2004 Sep 28	15379548
The computer modelling of human TRH receptor, TRH and TRH-like peptides.	2005	15544424
Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes.	2005 Apr	15615696
Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate.	2005 Aug 2	16004974
Nanoparticles on the basis of highly functionalized dextrans.	2005 Aug 3	16045324
Identification of novel bradykinin-potentiating peptides and C-type natriuretic peptide from Lachesis muta venom.	2005 Jul	15876444
CLPM: a cross-linked peptide mapping algorithm for mass spectrometric analysis.	2005 Jul 15	16026606
Total synthesis of pinnamine and anatoxin-a via a common intermediate. A caveat on the anatoxin-a endgame.	2005 Jul 8	15989354
Preparation and reactivity of aminoacyl pyroglutamates. Facile synthesis of 10-membered-ring cyclic dipeptides derived from 1,4-diaminobutyric and glutamic acids.	2005 Mar	15635648
Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques.	2005 Nov 4	16091362
Cloning, expression, characterization, and crystallization of a glutaminyl cyclase from human bone marrow: a single zinc metalloenzyme.	2005 Sep	16084398
CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.	2006 Feb	16095585

Patents

Sample Use Guides

In Vivo Use Guide

Topical, as a compontent of lotions, creams and other cosmetic products.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:33:07 GMT 2023` Edited by `admin` on `Fri Dec 15 16:33:07 GMT 2023`
Record UNII	1V74VH163T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SODIUM PIDOLATE

Common Name

English

SODIUM L-PYROGLUTAMATE

Common Name

English

Sodium pidolate [WHO-DD]

Common Name

English

L-SODIUM PIDOLATE

Common Name

English

PROLINE, 5-OXO-, MONOSODIUM SALT, L-

Common Name

English

2-PYRROLIDONE-5-CARBOXYLIC ACID SODIUM SALT

Common Name

English

SODIUM PYROGLUTAMATE

Common Name

English

Code System Code Type Description

CAS

28874-51-3