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Details

Stereochemistry ABSOLUTE
Molecular Formula C5H6NO3.Na
Molecular Weight 151.0958
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM PIDOLATE

SMILES

[Na+].[O-]C(=O)[C@@H]1CCC(=O)N1

InChI

InChIKey=CRPCXAMJWCDHFM-DFWYDOINSA-M
InChI=1S/C5H7NO3.Na/c7-4-2-1-3(6-4)5(8)9;/h3H,1-2H2,(H,6,7)(H,8,9);/q;+1/p-1/t3-;/m0./s1

HIDE SMILES / InChI

Molecular Formula C5H6NO3
Molecular Weight 128.106
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Zinc Pidolate (Zinc PCA) is a topical skin product with purifying, astingent, anti-inflammatory, antiseptic activity. It has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. Zinc Pidolate has also being shown to be effective against halitosis. Zinc PCA prevents the UV-induced MMP-1 production in vitro by suppressing the activation of AP-1. Zinc PCA was also able to enhance type I collagen synthesis in NHDFs, by increasing the expression of the mRNA encoding the ascorbic acid transporter SVCT2 in non-UV irradiated NHDFs, which suggests its promising effect against not only photoaged skin but also for the simple atrophic change of intrinsic skin ageing. Zinc PCA is able to suppress sebum secretion by inhibiting 5-α reductase in hyperseborrhea, to suppress body odor by forming zinc salts with short-chain fatty acids, to suppress wrinkles by inhibiting AP-1 to and inhibit bacterial growth including acne related Propionibacterium acnes.

CNS Activity

Curator's Comment: Known to penetrate blood-brain barrier in rats. Is produced naturally in human brain

Originator

Sources: Haitinger, L.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEANSING FOAMING GEL ACNE PRO SKIN- zinc pidolate gel

Approved Use

Lange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne.

Launch Date

1.34256958E12
Primary
Unknown

Approved Use

Unknown
Primary
EcoCare™ Zinclean

Approved Use

Use in anti-dandruff shampoos
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Human seminal relaxin is a product of the same gene as human luteal relaxin.
1992 May
Fast analysis of water samples for detection of anions by capillary zone electrophoresis.
2001
In vivo confocal Raman microspectroscopy of the skin: noninvasive determination of molecular concentration profiles.
2001 Mar
Major outer membrane proteins and proteolytic processing of RgpA and Kgp of Porphyromonas gingivalis W50.
2002 Apr 1
Complete structure of an increasing capillary permeability protein (ICPP) purified from Vipera lebetina venom. ICPP is angiogenic via vascular endothelial growth factor receptor signalling.
2002 Aug 16
The primary structure of cassowary (Casuarius casuarius) goose type lysozyme.
2002 Jan
Five- and six-membered ring opening of pyroglutamic diketopiperazine.
2002 Mar 22
Stereoselective synthesis of dipeptide beta-turn mimetics: 7-benzyl and 8-phenyl substituted azabicyclo[4.3.0]nonane amino acid esters.
2002 Sep 6
Determination of the post-translational modifications of salivary acidic proline-rich proteins.
2003 Apr
Characterization and sequence of tomato 2S seed albumin: a storage protein with sequence similarities to the fruit lectin.
2003 Apr
Refolding of amphioxus insulin-like peptide: implications of a bifurcating evolution of the different folding behavior of insulin and insulin-like growth factor 1.
2003 Aug 19
Solution structure of the cytotoxic RNase 4 from oocytes of bullfrog Rana catesbeiana.
2003 Feb 28
Characterization of a new bradykinin-potentiating peptide (TmF) from Trimeresurus mucrosquamatus.
2003 Jul
[Evolution of the neuroprotection concept].
2003 Mar-Apr
[Oleyl pyroglutamate for use as transdermal enhancer and its enhancing mechanism].
2003 May
[Characteristics of pyrrolidone pharmacokinetics in rats].
2003 Nov-Dec
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.
2004 Apr 9
Glutamine in commercial liquid nutritional products.
2004 Aug 11
Integrative annotation of 21,037 human genes validated by full-length cDNA clones.
2004 Jun
Chemical characterization of a lambda I amyloid protein isolated from formalin-fixed and paraffin-embedded tissue sections.
2004 Mar
Synthesis of (2S,3R)-[3',3',3'-2H3]-valine and (2S,3S)-4-fluorovaline.
2004 May 7
Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+ -channels (IA currents) of cerebellum granular cells.
2004 Oct 15
Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin.
2004 Oct 19
Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions.
2004 Sep
Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells.
2004 Sep 28
The computer modelling of human TRH receptor, TRH and TRH-like peptides.
2005
Physiological and pathological aspects of GSH metabolism.
2005 Feb
Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid).
2005 Jul
The removal of pyroglutamic acid from monoclonal antibodies without denaturation of the protein chains.
2005 Jul 1
CLPM: a cross-linked peptide mapping algorithm for mass spectrometric analysis.
2005 Jul 15
Comparative effect of a new mouthrinse containing chlorhexidine, triclosan and zinc on volatile sulphur compounds: a randomized, crossover, double-blind study.
2016 Aug
Patents

Sample Use Guides

In Vivo Use Guide
Sources: Topical, as a compontent of lotions, creams and other cosmetic products.
Topical, as a compontent of lotions, creams and other cosmetic products.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 16 20:28:11 UTC 2022
Edited
by admin
on Fri Dec 16 20:28:11 UTC 2022
Record UNII
1V74VH163T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM PIDOLATE
WHO-DD  
Common Name English
SODIUM L-PYROGLUTAMATE
Common Name English
Sodium pidolate [WHO-DD]
Common Name English
L-SODIUM PIDOLATE
Common Name English
PROLINE, 5-OXO-, MONOSODIUM SALT, L-
Common Name English
2-PYRROLIDONE-5-CARBOXYLIC ACID SODIUM SALT
Common Name English
SODIUM PYROGLUTAMATE
Common Name English
Code System Code Type Description
CAS
28874-51-3
Created by admin on Fri Dec 16 20:28:11 UTC 2022 , Edited by admin on Fri Dec 16 20:28:11 UTC 2022
PRIMARY
DAILYMED
1V74VH163T
Created by admin on Fri Dec 16 20:28:11 UTC 2022 , Edited by admin on Fri Dec 16 20:28:11 UTC 2022
PRIMARY
NCI_THESAURUS
C84058
Created by admin on Fri Dec 16 20:28:12 UTC 2022 , Edited by admin on Fri Dec 16 20:28:12 UTC 2022
PRIMARY
ECHA (EC/EINECS)
249-277-1
Created by admin on Fri Dec 16 20:28:11 UTC 2022 , Edited by admin on Fri Dec 16 20:28:11 UTC 2022
PRIMARY
FDA UNII
1V74VH163T
Created by admin on Fri Dec 16 20:28:12 UTC 2022 , Edited by admin on Fri Dec 16 20:28:12 UTC 2022
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 16 20:28:12 UTC 2022 , Edited by admin on Fri Dec 16 20:28:12 UTC 2022
CONCEPT Industrial Aid
EVMPD
SUB04485MIG
Created by admin on Fri Dec 16 20:28:11 UTC 2022 , Edited by admin on Fri Dec 16 20:28:11 UTC 2022
PRIMARY
EPA CompTox
DTXSID50183074
Created by admin on Fri Dec 16 20:28:12 UTC 2022 , Edited by admin on Fri Dec 16 20:28:12 UTC 2022
PRIMARY
RXCUI
1364917
Created by admin on Fri Dec 16 20:28:12 UTC 2022 , Edited by admin on Fri Dec 16 20:28:12 UTC 2022
ALTERNATIVE
PUBCHEM
23668602
Created by admin on Fri Dec 16 20:28:12 UTC 2022 , Edited by admin on Fri Dec 16 20:28:12 UTC 2022
PRIMARY
RXCUI
235455
Created by admin on Fri Dec 16 20:28:12 UTC 2022 , Edited by admin on Fri Dec 16 20:28:12 UTC 2022
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE