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Details

Stereochemistry ABSOLUTE
Molecular Formula C5H6NO3.Na
Molecular Weight 151.0958
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM PIDOLATE

SMILES

[Na+].[O-]C(=O)[C@@H]1CCC(=O)N1

InChI

InChIKey=CRPCXAMJWCDHFM-DFWYDOINSA-M
InChI=1S/C5H7NO3.Na/c7-4-2-1-3(6-4)5(8)9;/h3H,1-2H2,(H,6,7)(H,8,9);/q;+1/p-1/t3-;/m0./s1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.98976928
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C5H6NO3
Molecular Weight 128.106
Charge -1
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Zinc Pidolate (Zinc PCA) is a topical skin product with purifying, astingent, anti-inflammatory, antiseptic activity. It has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. Zinc Pidolate has also being shown to be effective against halitosis. Zinc PCA prevents the UV-induced MMP-1 production in vitro by suppressing the activation of AP-1. Zinc PCA was also able to enhance type I collagen synthesis in NHDFs, by increasing the expression of the mRNA encoding the ascorbic acid transporter SVCT2 in non-UV irradiated NHDFs, which suggests its promising effect against not only photoaged skin but also for the simple atrophic change of intrinsic skin ageing. Zinc PCA is able to suppress sebum secretion by inhibiting 5-α reductase in hyperseborrhea, to suppress body odor by forming zinc salts with short-chain fatty acids, to suppress wrinkles by inhibiting AP-1 to and inhibit bacterial growth including acne related Propionibacterium acnes.

CNS Activity

Curator's Comment: Known to penetrate blood-brain barrier in rats. Is produced naturally in human brain

Originator

Sources: Haitinger, L.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
CLEANSING FOAMING GEL ACNE PRO SKIN- zinc pidolate gel

Approved Use

Lange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne.

Launch Date

2012
Primary
Unknown

Approved Use

Unknown
Primary
EcoCare™ Zinclean

Approved Use

Use in anti-dandruff shampoos
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Human seminal relaxin is a product of the same gene as human luteal relaxin.
1992 May
Comparison of the positive and negative ion electrospray mass spectra of some small peptides containing pyroglutamate.
2002
Continuous spectrometric assays for glutaminyl cyclase activity.
2002 Apr 1
CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV.
2002 Apr 2
The primary structure of cassowary (Casuarius casuarius) goose type lysozyme.
2002 Jan
Stereoselective total syntheses of the racemic form and the natural enantiomer of the marine alkaloid lepadiformine via a novel N-acyliminium ion/allylsilane spirocyclization strategy.
2002 Jun 14
Methacrylate derivatives incorporating pyroglutamic acid.
2002 Nov-Dec
Characterizing degradation products of peptides containing N-terminal Cys residues by (off-line high-performance liquid chromatography)/matrix-assisted laser desorption/ionization quadrupole time-of-flight measurements.
2003
Characterization and sequence of tomato 2S seed albumin: a storage protein with sequence similarities to the fruit lectin.
2003 Apr
Pressure/temperature combined treatments of precursors yield hormone-like peptides with pyroglutamate at the N terminus.
2003 Dec 31
Solution structure of the cytotoxic RNase 4 from oocytes of bullfrog Rana catesbeiana.
2003 Feb 28
Pyrrolidinones derived from (S)-pyroglutamic acid: penmacric acid and analogues.
2003 Jul 7
Proinsulin C-peptide and its C-terminal pentapeptide: degradation in human serum and Schiff base formation with subsequent CO2 incorporation.
2003 May
Structural characterization of native mouse zona pellucida proteins using mass spectrometry.
2003 Sep 5
Origin of diastereoselection in the hydrosilylation of chiral N-acyliminium intermediates derived from pyroglutamic acid.
2004 Apr 26
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.
2004 Apr 9
Glutamine in commercial liquid nutritional products.
2004 Aug 11
Toward the synthesis of pyroglutamate lauroyl ester: biocatalysis versus chemical catalysis.
2004 Feb
Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation-implications for immunological studies.
2004 Feb
Expression, purification, and characterization of avian Thy-1 from Lec1 mammalian and Tn5 insect cells.
2004 Feb
N-acetylation of the glutamate residue of intact glutathione conjugates in rats: a novel pathway for the metabolic processing of thiol adducts of xenobiotics.
2004 Jan
Integrative annotation of 21,037 human genes validated by full-length cDNA clones.
2004 Jun
Chemical characterization of a lambda I amyloid protein isolated from formalin-fixed and paraffin-embedded tissue sections.
2004 Mar
Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures.
2004 Mar-Apr
Mass spectrometric analysis of posttranslational modifications of a carrot extracellular glycoprotein.
2004 May 25
Synthesis of (2S,3R)-[3',3',3'-2H3]-valine and (2S,3S)-4-fluorovaline.
2004 May 7
Preventing the spontaneous modification of an HLA-A2-restricted peptide at an N-terminal glutamine or an internal cysteine residue enhances peptide antigenicity.
2004 May-Jun
Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+ -channels (IA currents) of cerebellum granular cells.
2004 Oct 15
Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin.
2004 Oct 19
Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions.
2004 Sep
Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).
2004 Sep
The development of a higher throughput reactive intermediate screening assay incorporating micro-bore liquid chromatography-micro-electrospray ionization-tandem mass spectrometry and glutathione ethyl ester as an in vitro conjugating agent.
2004 Sep 21
Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells.
2004 Sep 28
The computer modelling of human TRH receptor, TRH and TRH-like peptides.
2005
Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes.
2005 Apr
Emerging roles of apelin in biology and medicine.
2005 Aug
Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate.
2005 Aug 2
Nanoparticles on the basis of highly functionalized dextrans.
2005 Aug 3
Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid.
2005 Aug 7
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital.
2005 Jul
Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid).
2005 Jul
CLPM: a cross-linked peptide mapping algorithm for mass spectrometric analysis.
2005 Jul 15
Total synthesis of pinnamine and anatoxin-a via a common intermediate. A caveat on the anatoxin-a endgame.
2005 Jul 8
Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides.
2005 May
Biomarker metabolites capturing the metabolite variance present in a rice plant developmental period.
2005 May 31
Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques.
2005 Nov 4
Cloning, expression, characterization, and crystallization of a glutaminyl cyclase from human bone marrow: a single zinc metalloenzyme.
2005 Sep
Synthesis of 1,3-dioxo-hexahydropyrido[1,2-c][1,3]diazepine carboxylates, a new bicyclic skeleton formed by ring expansion-RCM methodology.
2005 Sep 21
Thermostability and in vitro digestibility of a purified major allergen 2S albumin (Ses i 1) from white sesame seeds (Sesamum indicum L.).
2005 Sep 25
CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.
2006 Feb
Patents

Sample Use Guides

In Vivo Use Guide
Sources: Topical, as a compontent of lotions, creams and other cosmetic products.
Topical, as a compontent of lotions, creams and other cosmetic products.
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:31:08 GMT 2025
Edited
by admin
on Mon Mar 31 18:31:08 GMT 2025
Record UNII
1V74VH163T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
2-PYRROLIDONE-5-CARBOXYLIC ACID SODIUM SALT
Preferred Name English
SODIUM PIDOLATE
WHO-DD  
Common Name English
SODIUM L-PYROGLUTAMATE
Common Name English
Sodium pidolate [WHO-DD]
Common Name English
L-SODIUM PIDOLATE
Common Name English
PROLINE, 5-OXO-, MONOSODIUM SALT, L-
Common Name English
SODIUM PYROGLUTAMATE
Common Name English
Code System Code Type Description
CAS
28874-51-3
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
PRIMARY
DAILYMED
1V74VH163T
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
PRIMARY
NCI_THESAURUS
C84058
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
PRIMARY
ECHA (EC/EINECS)
249-277-1
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
PRIMARY
FDA UNII
1V74VH163T
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
CONCEPT Industrial Aid
EVMPD
SUB04485MIG
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
PRIMARY
EPA CompTox
DTXSID50183074
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
PRIMARY
SMS_ID
100000084973
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
PRIMARY
RXCUI
1364917
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
ALTERNATIVE
PUBCHEM
23668602
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
PRIMARY
RXCUI
235455
Created by admin on Mon Mar 31 18:31:08 GMT 2025 , Edited by admin on Mon Mar 31 18:31:08 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE