| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H27NO3 |
| Molecular Weight | 341.444 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1(C)C(C(=O)C2=CN(CCCCC(O)=O)C3=C2C=CC=C3)C1(C)C
InChI
InChIKey=UUTHIAPDCFFQKQ-UHFFFAOYSA-N
InChI=1S/C21H27NO3/c1-20(2)19(21(20,3)4)18(25)15-13-22(12-8-7-11-17(23)24)16-10-6-5-9-14(15)16/h5-6,9-10,13,19H,7-8,11-12H2,1-4H3,(H,23,24)
| Molecular Formula | C21H27NO3 |
| Molecular Weight | 341.444 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
UR-144 N-pentanoic acid is a potent synthetic cannabinoid designed by Abbott Laboratories as a CB2 selective agonist for pain management. UR-144 N-pentanoic acid is a metabolite of another CB2-selective cannabinoid UR-144. Pre-clinical studies of nociceptive and neuropathic pain have shown that CB2-selective ligands are analgesics without causing the adverse side effects linked with CB1 receptor activation. However, nor UR-144 nor UR-144 N-pentanoic acid has no therapeutic application.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
Patents
Sample Use Guides
Phoenix Amphotropic (AMPHO) cell line were washed twice with Opti-MEM I Reduced Serum Medium to remove any remaining FBS, and 100 μL of Opti-MEM I was added. The Nano-Glo Live Cell reagent (Promega), a nonlytic detection reagent containing the cell permeable furimazine substrate, was prepared by diluting the Nano-Glo Live Cell substrate 20× using Nano-Glo LCS Dilution buffer, and 25 μL was added to each well. Subsequently, the plate was placed in a luminometer, the GloMAX96 (Promega). Luminescence was monitored during the equilibration period until the signal stabilized (30−45 min). For agonist experiments, we added 10 μL per well of test compounds (UR-144 N-pentanoic acid), present as 13.5× stocks in 50% methanol in Opti-MEM I. The luminescence was continuously detected for 120 min. Solvent controls were run in all experiments; the final concentration of methanol (3.7%) did not pose a problem given the short readout time of the assay.
