ITEZOCABTAGENE AUTOLEUCEL

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 02:25:04 GMT 2025` Edited by `admin` on `Wed Apr 02 02:25:04 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cell
Fraction Name	t-cells
Record UNII	1T1JX1GA68
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ITEZOCABTAGENE AUTOLEUCEL

Official Name

English

AUTOLOGOUS T CELLS OBTAINED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS BY LEUKAPHERESIS, TRANSDUCED WITH A NON-REPLICATING MOLONEY MURINE LEUKAEMIA VIRUS (MMLV) VECTOR, ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) UNDER THE CONTROL OF THE 5' LONG TERMINAL REP

Preferred Name

English

itezocabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

INN

11887

Created by admin on Wed Apr 02 02:25:04 GMT 2025 , Edited by admin on Wed Apr 02 02:25:04 GMT 2025

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SMS_ID

300000039128

Created by admin on Wed Apr 02 02:25:04 GMT 2025 , Edited by admin on Wed Apr 02 02:25:04 GMT 2025

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FDA UNII

1T1JX1GA68

Created by admin on Wed Apr 02 02:25:04 GMT 2025 , Edited by admin on Wed Apr 02 02:25:04 GMT 2025

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NCI_THESAURUS

C203128

Created by admin on Wed Apr 02 02:25:04 GMT 2025 , Edited by admin on Wed Apr 02 02:25:04 GMT 2025

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Related Record Type Details


					1T1JX1GA68

ITEZOCABTAGENE AUTOLEUCEL

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
ACTIVATION	ACTIVATOR	IMMUNOLOGICAL	MACS GMP CD28 PURE	ZL3BS1J3LY
ACTIVATION	ACTIVATOR	IMMUNOLOGICAL	MUROMONAB-CD3	JGA39ICE2V
CAR T-EXPRESSION	TRANSFECTION	RETROVIRAL TRANSFECTION	ITEZOCABTAGENE AUTOLEUCEL RETROVIRAL VECTOR	627T8INJ04

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					ITEZOCABTAGENE AUTOLEUCEL EXPRESSED CD30 CHIMERIC ANTIGEN RECEPTOR	6D9ZG1S022
INSERTED GENE EXPRESSION VECTOR					ITEZOCABTAGENE AUTOLEUCEL TRANSGENE INSERT	5XHL336SCK