LIGUFALIMAB

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 15:19:13 GMT 2023` Edited by `admin` on `Sat Dec 16 15:19:13 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	1S4338NZB8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LIGUFALIMAB

Official Name

English

ligufalimab [INN]

Common Name

English

IMMUNOGLOBULIN G4 (225-PROLINE), ANTI-(HUMAN CD47 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL AK117 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL AK117 .KAPPA.-CHAIN, DIMER

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C176868

Created by admin on Sat Dec 16 15:19:13 GMT 2023 , Edited by admin on Sat Dec 16 15:19:13 GMT 2023

PRIMARY

INN

11810

Created by admin on Sat Dec 16 15:19:13 GMT 2023 , Edited by admin on Sat Dec 16 15:19:13 GMT 2023

PRIMARY

FDA UNII

1S4338NZB8

Created by admin on Sat Dec 16 15:19:13 GMT 2023 , Edited by admin on Sat Dec 16 15:19:13 GMT 2023

PRIMARY

CAS

2428381-55-7

Created by admin on Sat Dec 16 15:19:13 GMT 2023 , Edited by admin on Sat Dec 16 15:19:13 GMT 2023

PRIMARY

From	To
1_22	1_96
1_144	1_200
1_131	3_214
1_258	1_318
1_364	1_422
1_223	2_223
1_226	2_226
2_22	2_96
2_144	2_200
2_131	4_214
2_258	2_318
2_364	2_422
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_294
N	2_294

Related Record Type Details


					1S4338NZB8

LIGUFALIMAB

ACTIVE MOIETY

Comments:

CD47 serves as the ligand for a receptor on these innate immune cells, signal regulatory protein alpha (SIRPα), which in turn delivers an inhibitory signal for phagocytosis

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL