2,4-Diamino-6-hydroxymethylpteridine

NC1=NC2=C(N=C(CO)C=N2)C(N)=N1

InChIKey=CYNARAWTVHQHDI-UHFFFAOYSA-N

InChI=1S/C7H8N6O/c8-5-4-6(13-7(9)12-5)10-1-3(2-14)11-4/h1,14H,2H2,(H4,8,9,10,12,13)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

PubMed

Title	Date	PubMed
Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model.	2008-11	18789931
Prediction of genotoxicity of chemical compounds by statistical learning methods.	2005-06	15962942
Determination of the chiral and achiral related substances of methotrexate by cyclodextrin-modified micellar electrokinetic chromatography.	2004-08	15352016
Photohydrolysis of methotrexate produces pteridine, which induces poly-G-specific DNA damage through photoinduced electron transfer.	2002-11	12462639
Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii.	2001-07-19	11448221
Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds.	1999-08-26	10464017

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:52:09 GMT 2025` Edited by `admin` on `Mon Mar 31 21:52:09 GMT 2025`
Record UNII	1RU16O4RO0
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

METHOTREXATE IMPURITY A [EP IMPURITY]

Preferred Name

English

2,4-Diamino-6-hydroxymethylpteridine

Systematic Name

English

6-PTERIDINEMETHANOL, 2,4-DIAMINO-

Systematic Name

English

(2,4-DIAMINOPTERIDIN-6-YL)METHANOL

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID10915479