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Details

Stereochemistry ACHIRAL
Molecular Formula C7H8N6O
Molecular Weight 192.1783
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 2,4-DIAMINO-6-HYDROXYMETHYLPTERIDINE

SMILES

c1c(CO)nc2c(N)[nH]c(=N)nc2n1

InChI

InChIKey=CYNARAWTVHQHDI-UHFFFAOYSA-N
InChI=1S/C7H8N6O/c8-5-4-6(13-7(9)12-5)10-1-3(2-14)11-4/h1,14H,2H2,(H4,8,9,10,12,13)

HIDE SMILES / InChI

Molecular Formula C7H8N6O
Molecular Weight 192.1783
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii.
2001 Jul 19
Photohydrolysis of methotrexate produces pteridine, which induces poly-G-specific DNA damage through photoinduced electron transfer.
2002 Nov
Determination of the chiral and achiral related substances of methotrexate by cyclodextrin-modified micellar electrokinetic chromatography.
2004 Aug
Prediction of genotoxicity of chemical compounds by statistical learning methods.
2005 Jun
Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model.
2008 Nov
Patents
Substance Class Chemical
Created
by admin
on Sat Jun 26 14:36:12 UTC 2021
Edited
by admin
on Sat Jun 26 14:36:12 UTC 2021
Record UNII
1RU16O4RO0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
2,4-DIAMINO-6-HYDROXYMETHYLPTERIDINE
Systematic Name English
6-PTERIDINEMETHANOL, 2,4-DIAMINO-
Systematic Name English
METHOTREXATE IMPURITY A [EP]
Common Name English
(2,4-DIAMINOPTERIDIN-6-YL)METHANOL
Systematic Name English
Code System Code Type Description
CAS
945-24-4
Created by admin on Sat Jun 26 14:36:12 UTC 2021 , Edited by admin on Sat Jun 26 14:36:12 UTC 2021
PRIMARY
FDA UNII
1RU16O4RO0
Created by admin on Sat Jun 26 14:36:12 UTC 2021 , Edited by admin on Sat Jun 26 14:36:12 UTC 2021
PRIMARY
PUBCHEM
70347
Created by admin on Sat Jun 26 14:36:12 UTC 2021 , Edited by admin on Sat Jun 26 14:36:12 UTC 2021
PRIMARY
ECHA (EC/EINECS)
213-412-2
Created by admin on Sat Jun 26 14:36:12 UTC 2021 , Edited by admin on Sat Jun 26 14:36:12 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
UNSPECIFIED
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UNSPECIFIED
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP