PROPISERGIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H25N3O2
Molecular Weight	339.4314
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2CC3=CN(C)C4=C3C(=CC=C4)C2=C1

InChI

InChIKey=XUKAVPATXGYVKJ-WPKBUWHJSA-N

InChI=1S/C20H25N3O2/c1-12(11-24)21-20(25)14-7-16-15-5-4-6-17-19(15)13(9-22(17)2)8-18(16)23(3)10-14/h4-7,9,12,14,18,24H,8,10-11H2,1-3H3,(H,21,25)/t12-,14+,18+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H25N3O2
Molecular Weight	339.4314
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/42933 | https://www.ncbi.nlm.nih.gov/pubmed/7282219 | Biogenic Amines (1992), 8, (3-4), 267-75.

Propisergide is a lysergic acid derivative patented by Sandoz Ltd. as an α-adrenoceptor-blocking agent with marked specific 5-HT receptor antagonist activity. In preclinical trials, Propisergide inhibited tryptamine tremor in rats and adrenaline-induced aggregation of blood platelets.

Originator

Approval Year

PubMed

Title	Date	PubMed
Studies on the inhibition of adrenaline-induced aggregation of blood platelets.	1979	42933

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:26:07 GMT 2025` Edited by `admin` on `Wed Apr 02 08:26:07 GMT 2025`
Record UNII	1Q1AWW2JET
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

propisergide [INN]

Preferred Name

English

PROPISERGIDE

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C221

Created by admin on Wed Apr 02 08:26:07 GMT 2025 , Edited by admin on Wed Apr 02 08:26:07 GMT 2025

Code System Code Type Description

ChEMBL

CHEMBL2105371

Created by admin on Wed Apr 02 08:26:07 GMT 2025 , Edited by admin on Wed Apr 02 08:26:07 GMT 2025

PRIMARY

SMS_ID

100000081360

Created by admin on Wed Apr 02 08:26:08 GMT 2025 , Edited by admin on Wed Apr 02 08:26:08 GMT 2025

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FDA UNII

1Q1AWW2JET

Created by admin on Wed Apr 02 08:26:07 GMT 2025 , Edited by admin on Wed Apr 02 08:26:07 GMT 2025

PRIMARY

EVMPD

SUB10113MIG

Created by admin on Wed Apr 02 08:26:07 GMT 2025 , Edited by admin on Wed Apr 02 08:26:07 GMT 2025

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INN

3973

Created by admin on Wed Apr 02 08:26:07 GMT 2025 , Edited by admin on Wed Apr 02 08:26:07 GMT 2025

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EPA CompTox

DTXSID701018134

Created by admin on Wed Apr 02 08:26:07 GMT 2025 , Edited by admin on Wed Apr 02 08:26:07 GMT 2025

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CAS

5793-04-4

Created by admin on Wed Apr 02 08:26:07 GMT 2025 , Edited by admin on Wed Apr 02 08:26:07 GMT 2025

PRIMARY

PUBCHEM

20055549

Created by admin on Wed Apr 02 08:26:07 GMT 2025 , Edited by admin on Wed Apr 02 08:26:07 GMT 2025

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NCI_THESAURUS

C66490

Created by admin on Wed Apr 02 08:26:07 GMT 2025 , Edited by admin on Wed Apr 02 08:26:07 GMT 2025

PRIMARY

Related Record Type Details


					1Q1AWW2JET

PROPISERGIDE

ACTIVE MOIETY

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/42933 | https://www.ncbi.nlm.nih.gov/pubmed/7282219 | Biogenic Amines (1992), 8, (3-4), 267-75.

Originator

Approval Year

PubMed

Patents

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/42933 | https://www.ncbi.nlm.nih.gov/pubmed/7282219 | Biogenic Amines (1992), 8, (3-4), 267-75.