Details
Stereochemistry | ACHIRAL |
Molecular Formula | C7H19N3.3ClH |
Molecular Weight | 254.629 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.Cl.NCCCCNCCCN
InChI
InChIKey=LCNBIHVSOPXFMR-UHFFFAOYSA-N
InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C7H19N3 |
Molecular Weight | 145.2459 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL3729 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
112.0 nM [Ki] | ||
Target ID: CHEMBL3510 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
1.0 µM [Ki] | ||
Target ID: CHEMBL205 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
1.11 µM [Ki] | ||
Target ID: CHEMBL4789 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20590092 |
1.22 µM [Ki] |
PubMed
Title | Date | PubMed |
---|---|---|
Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: potential rational drug design lead frameworks. | 2001 |
|
Possible implications of arginase and diamine oxidase in prostatic carcinoma. | 2001 |
|
Cellular pharmacodynamics of the cytotoxic guanidino-containing drug CHS 828. Comparison with methylglyoxal-bis(guanylhydrazone). | 2001 Apr 20 |
|
Polyamine and thiol metabolism in Trypanosoma granulosum: similarities with Trypanosoma cruzi. | 2001 Apr 20 |
|
Rat coagulating gland secretion contains a kinesin heavy chain-like protein acting as a type IV transglutaminase substrate. | 2001 Apr 24 |
|
Biogenic amines in vacuum-packaged and carbon dioxide-controlled atmosphere-packaged fresh pork stored at -1.50 degrees C. | 2001 Feb |
|
Role of uremic toxins in exacerbating anemia in renal failure. | 2001 Feb |
|
Multiple polyamine transport systems on the vacuolar membrane in yeast. | 2001 Feb 1 |
|
Chemical, microbiological, and AromaScan evaluation of mahi-mahi fillets under various storage conditions. | 2001 Jan |
|
Polyamine regulation of ornithine decarboxylase and its antizyme in intestinal epithelial cells. | 2001 Jan |
|
Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents. | 2001 Jan 22 |
|
Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial. | 2001 Jan 3 |
|
Inhibitory effects on HIV-1 protease of tri-p-coumaroylspermidine from Artemisia caruifolia and related amides. | 2001 Jul |
|
Occurrence of cadaverine in hairy roots of Brugmansia candida. | 2001 Jul |
|
Raman study of the interaction between polyamines and a GC oligonucleotide. | 2001 Jul 13 |
|
Polyamines regulate gap junction communication in connexin 43-expressing cells. | 2001 Jul 15 |
|
Significance of asymmetric sites in choosing siderophores as deferration agents. | 2001 Jul 19 |
|
Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives. | 2001 Jul 19 |
|
A monoclonal antibody against the glutaraldehyde-conjugated polyamine, putrescine: application to immunocytochemistry. | 2001 Jun |
|
Agmatine and putrescine uptake in the human glioma cell line SK-MG-1. | 2001 Jun |
|
Antizyme regulates the degradation of ornithine decarboxylase in fission yeast Schizosaccharomyces pombe. Study in the spe2 knockout strains. | 2001 Jun 15 |
|
Determination of polyamines in human saliva by high-performance liquid chromatography with fluorescence detection. | 2001 Jun 5 |
|
Polyamines secreted by cancer cells possibly account for the impairment of the human erythrocyte sodium pump activity. | 2001 Mar |
|
Structures of tryparedoxins revealing interaction with trypanothione. | 2001 Mar |
|
A mammalian sequence-dependent upstream open reading frame mediates polyamine-regulated translation in yeast. | 2001 Mar |
|
Small molecular mass inhibitor of growth of MDCK cells derived from pig spinal cord. | 2001 Mar |
|
Polyamine cytotoxicity in the presence of bovine serum amine oxidase. | 2001 Mar 23 |
|
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. | 2001 Mar 30 |
|
Structural bases for inhibitor binding and catalysis in polyamine oxidase. | 2001 Mar 6 |
|
Chemoprevention by difluoromethylornithine: correlation of an in vitro human cell assay with human clinical data for biomarker modulation. | 2001 Mar-Apr |
|
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase. | 2001 May |
|
Involvement of semicarbazide-sensitive amine oxidase in tresperimus metabolism in human and in rat. | 2001 May |
|
Guanidino-containing drugs in cancer chemotherapy: biochemical and clinical pharmacology. | 2001 May 15 |
|
Polyamines in the basal ganglia of human brain. Influence of aging and degenerative movement disorders. | 2001 May 18 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:48:53 GMT 2023
by
admin
on
Sat Dec 16 01:48:53 GMT 2023
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Record UNII |
1O14BED398
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Record Status |
Validated (UNII)
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Record Version |
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334-50-9
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206-379-0
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DTXSID0059825
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1O14BED398
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m10139
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528399
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9539
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PARENT -> SALT/SOLVATE |