U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C7H19N3.3ClH
Molecular Weight 254.629
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SPERMIDINE HYDROCHLORIDE

SMILES

Cl.Cl.Cl.NCCCCNCCCN

InChI

InChIKey=LCNBIHVSOPXFMR-UHFFFAOYSA-N
InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C7H19N3
Molecular Weight 145.2459
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
112.0 nM [Ki]
1.0 µM [Ki]
1.11 µM [Ki]
1.22 µM [Ki]
PubMed

PubMed

TitleDatePubMed
Specific peptide inhibitors of trypanothione reductase with backbone structures unrelated to that of substrate: potential rational drug design lead frameworks.
2001
Possible implications of arginase and diamine oxidase in prostatic carcinoma.
2001
Cellular pharmacodynamics of the cytotoxic guanidino-containing drug CHS 828. Comparison with methylglyoxal-bis(guanylhydrazone).
2001 Apr 20
Polyamine and thiol metabolism in Trypanosoma granulosum: similarities with Trypanosoma cruzi.
2001 Apr 20
Rat coagulating gland secretion contains a kinesin heavy chain-like protein acting as a type IV transglutaminase substrate.
2001 Apr 24
Biogenic amines in vacuum-packaged and carbon dioxide-controlled atmosphere-packaged fresh pork stored at -1.50 degrees C.
2001 Feb
Role of uremic toxins in exacerbating anemia in renal failure.
2001 Feb
Multiple polyamine transport systems on the vacuolar membrane in yeast.
2001 Feb 1
Chemical, microbiological, and AromaScan evaluation of mahi-mahi fillets under various storage conditions.
2001 Jan
Polyamine regulation of ornithine decarboxylase and its antizyme in intestinal epithelial cells.
2001 Jan
Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.
2001 Jan 22
Alpha-difluoromethylornithine and polyamine levels in the human prostate: results of a phase IIa trial.
2001 Jan 3
Inhibitory effects on HIV-1 protease of tri-p-coumaroylspermidine from Artemisia caruifolia and related amides.
2001 Jul
Occurrence of cadaverine in hairy roots of Brugmansia candida.
2001 Jul
Raman study of the interaction between polyamines and a GC oligonucleotide.
2001 Jul 13
Polyamines regulate gap junction communication in connexin 43-expressing cells.
2001 Jul 15
Significance of asymmetric sites in choosing siderophores as deferration agents.
2001 Jul 19
Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives.
2001 Jul 19
A monoclonal antibody against the glutaraldehyde-conjugated polyamine, putrescine: application to immunocytochemistry.
2001 Jun
Agmatine and putrescine uptake in the human glioma cell line SK-MG-1.
2001 Jun
Antizyme regulates the degradation of ornithine decarboxylase in fission yeast Schizosaccharomyces pombe. Study in the spe2 knockout strains.
2001 Jun 15
Determination of polyamines in human saliva by high-performance liquid chromatography with fluorescence detection.
2001 Jun 5
Polyamines secreted by cancer cells possibly account for the impairment of the human erythrocyte sodium pump activity.
2001 Mar
Structures of tryparedoxins revealing interaction with trypanothione.
2001 Mar
A mammalian sequence-dependent upstream open reading frame mediates polyamine-regulated translation in yeast.
2001 Mar
Small molecular mass inhibitor of growth of MDCK cells derived from pig spinal cord.
2001 Mar
Polyamine cytotoxicity in the presence of bovine serum amine oxidase.
2001 Mar 23
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.
2001 Mar 30
Structural bases for inhibitor binding and catalysis in polyamine oxidase.
2001 Mar 6
Chemoprevention by difluoromethylornithine: correlation of an in vitro human cell assay with human clinical data for biomarker modulation.
2001 Mar-Apr
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
2001 May
Involvement of semicarbazide-sensitive amine oxidase in tresperimus metabolism in human and in rat.
2001 May
Guanidino-containing drugs in cancer chemotherapy: biochemical and clinical pharmacology.
2001 May 15
Polyamines in the basal ganglia of human brain. Influence of aging and degenerative movement disorders.
2001 May 18
Patents
Substance Class Chemical
Created
by admin
on Sat Dec 16 01:48:53 GMT 2023
Edited
by admin
on Sat Dec 16 01:48:53 GMT 2023
Record UNII
1O14BED398
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SPERMIDINE HYDROCHLORIDE
Systematic Name English
SPERMIDINE TRIHYDROCHLORIDE
MI  
Systematic Name English
1,4-BUTANEDIAMINE, N1-(3-AMINOPROPYL)-, HYDROCHLORIDE (1:3)
Systematic Name English
NSC-528399
Code English
SPERMIDINE TRIHYDROCHLORIDE [MI]
Common Name English
SPERMIDINE HCL
INCI  
INCI  
Official Name English
1,4-BUTANEDIAMINE, N-(3-AMINOPROPYL)-, TRIHYDROCHLORIDE
Common Name English
SPERMIDINE HCL [INCI]
Common Name English
Code System Code Type Description
CAS
334-50-9
Created by admin on Sat Dec 16 01:48:53 GMT 2023 , Edited by admin on Sat Dec 16 01:48:53 GMT 2023
PRIMARY
ECHA (EC/EINECS)
206-379-0
Created by admin on Sat Dec 16 01:48:53 GMT 2023 , Edited by admin on Sat Dec 16 01:48:53 GMT 2023
PRIMARY
EPA CompTox
DTXSID0059825
Created by admin on Sat Dec 16 01:48:53 GMT 2023 , Edited by admin on Sat Dec 16 01:48:53 GMT 2023
PRIMARY
FDA UNII
1O14BED398
Created by admin on Sat Dec 16 01:48:53 GMT 2023 , Edited by admin on Sat Dec 16 01:48:53 GMT 2023
PRIMARY
MERCK INDEX
m10139
Created by admin on Sat Dec 16 01:48:53 GMT 2023 , Edited by admin on Sat Dec 16 01:48:53 GMT 2023
PRIMARY Merck Index
NSC
528399
Created by admin on Sat Dec 16 01:48:53 GMT 2023 , Edited by admin on Sat Dec 16 01:48:53 GMT 2023
PRIMARY
PUBCHEM
9539
Created by admin on Sat Dec 16 01:48:53 GMT 2023 , Edited by admin on Sat Dec 16 01:48:53 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE