BAZLITORAN SODIUM

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NCATS

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Mon Mar 31 23:37:21 GMT 2025` Edited by `admin` on `Mon Mar 31 23:37:21 GMT 2025`
Sequence Type	OLIGONUCLEOTIDE
Record UNII	1NLR4WAG4U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BAZLITORAN SODIUM

Official Name

English

IMO-8400 SODIUM

Preferred Name

English

ALL-P-AMBO-2'-DEOXY-P-THIOCYTIDYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-2'-DEOXY-P-THIOADENYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-2'-DEOXY-P-THIOCYTIDYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-2'-O-METHYL-P-THIOGUANYLYL-(3'->5')-2'-O-METHYL-P-THIOURIDYLYL-(

Systematic Name

English

BAZLITORAN SODIUM [USAN]

Common Name

English

DNA, (P-THIO)(C-T-A-T-C-T-RGM-RUM-M5C-C7G-T-T-C-T-C-T-RGM-RUM), SODIUM SALT (1:17)

Systematic Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

472615

Created by admin on Mon Mar 31 23:37:21 GMT 2025 , Edited by admin on Mon Mar 31 23:37:21 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C166508

Created by admin on Mon Mar 31 23:37:21 GMT 2025 , Edited by admin on Mon Mar 31 23:37:21 GMT 2025

PRIMARY

FDA UNII

1NLR4WAG4U

Created by admin on Mon Mar 31 23:37:21 GMT 2025 , Edited by admin on Mon Mar 31 23:37:21 GMT 2025

PRIMARY

SMS_ID

300000044476

Created by admin on Mon Mar 31 23:37:21 GMT 2025 , Edited by admin on Mon Mar 31 23:37:21 GMT 2025

PRIMARY

CAS

1613607-40-1

Created by admin on Mon Mar 31 23:37:21 GMT 2025 , Edited by admin on Mon Mar 31 23:37:21 GMT 2025

PRIMARY

USAN

EF-109

Created by admin on Mon Mar 31 23:37:21 GMT 2025 , Edited by admin on Mon Mar 31 23:37:21 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_7-1_8;1_17-1_18	4 / 18
Deoxyribose (DNA)	1_1-1_6;1_9-1_16	14 / 18

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_18	17 / 17

Related Record Type Details


					2U46M95B5M

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					2U46M95B5M

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
BASE SUBSTITUTION	[1_9]		CYTOSINE		5-METHYLCYTOSINE	6R795CQT4H
BASE SUBSTITUTION	[1_10]		GUANINE	Amount:	7-DEAZAGUANINE	GPL8T5ZO3M

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:CALCULATED	CHEMICAL