U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry UNKNOWN
Molecular Formula C24H33N3O2S.2ClH
Molecular Weight 500.525
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIXYRAZINE DIHYDROCHLORIDE

SMILES

Cl.Cl.CC(CN1CCN(CCOCCO)CC1)CN2C3=C(SC4=C2C=CC=C4)C=CC=C3

InChI

InChIKey=PZYZOXQAAJBNOK-UHFFFAOYSA-N
InChI=1S/C24H33N3O2S.2ClH/c1-20(18-26-12-10-25(11-13-26)14-16-29-17-15-28)19-27-21-6-2-4-8-23(21)30-24-9-5-3-7-22(24)27;;/h2-9,20,28H,10-19H2,1H3;2*1H

HIDE SMILES / InChI
Molecular Formula C24H33N3O2S
Molecular Weight 427.603
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Dixyrazine is a typical antipsychotic of the phenothiazine group. Under a trademark Esucos, the drug was used in European countries as an antipsychotic, antiemetic and sedative with oral doses ranging from 20 to 75 mg daily. Dixyrazine has also been given by injection.

CNS Activity

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Maternal use of antipsychotics in early pregnancy and delivery outcome.
2008 Jun

Sample Use Guides

In Vivo Use Guide
The oral dose of dixyrazine ranges from 20 to 75 mg daily. Dixyrazine has also been given by intramuscular injection at 0.5 mg/kg
Route of Administration: Other
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:56:11 GMT 2023
Edited
by admin
on Fri Dec 15 16:56:11 GMT 2023
Record UNII
1N4Y3TZ2PC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIXYRAZINE DIHYDROCHLORIDE
MI  
Common Name English
ETHANOL, 2-(2-(4-(2-METHYL-3-(10H-PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINYL)ETHOXY)-, HYDROCHLORIDE (1:2)
Systematic Name English
NSC-169095
Code English
DIXYRAZINE DIHYDROCHLORIDE [MI]
Common Name English
Code System Code Type Description
MERCK INDEX
m4699
Created by admin on Fri Dec 15 16:56:11 GMT 2023 , Edited by admin on Fri Dec 15 16:56:11 GMT 2023
PRIMARY Merck Index
CAS
60539-20-0
Created by admin on Fri Dec 15 16:56:11 GMT 2023 , Edited by admin on Fri Dec 15 16:56:11 GMT 2023
PRIMARY
PUBCHEM
43296
Created by admin on Fri Dec 15 16:56:11 GMT 2023 , Edited by admin on Fri Dec 15 16:56:11 GMT 2023
PRIMARY
FDA UNII
1N4Y3TZ2PC
Created by admin on Fri Dec 15 16:56:11 GMT 2023 , Edited by admin on Fri Dec 15 16:56:11 GMT 2023
PRIMARY
NSC
169095
Created by admin on Fri Dec 15 16:56:11 GMT 2023 , Edited by admin on Fri Dec 15 16:56:11 GMT 2023
PRIMARY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966