DIXYRAZINE DIHYDROCHLORIDE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C24H33N3O2S.2ClH
Molecular Weight	500.525
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.CC(CN1CCN(CCOCCO)CC1)CN2C3=CC=CC=C3SC4=C2C=CC=C4

InChI

InChIKey=PZYZOXQAAJBNOK-UHFFFAOYSA-N

InChI=1S/C24H33N3O2S.2ClH/c1-20(18-26-12-10-25(11-13-26)14-16-29-17-15-28)19-27-21-6-2-4-8-23(21)30-24-9-5-3-7-22(24)27;;/h2-9,20,28H,10-19H2,1H3;2*1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C24H33N3O2S
Molecular Weight	427.603
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.drugfuture.com/mt/difebarbamate.pdf | https://www.ncbi.nlm.nih.gov/pubmed/3348073

Dixyrazine is a typical antipsychotic of the phenothiazine group. Under a trademark Esucos, the drug was used in European countries as an antipsychotic, antiemetic and sedative with oral doses ranging from 20 to 75 mg daily. Dixyrazine has also been given by injection.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Age estimation in 25-45 yrs. old females by physical and radiological methods.	2010-07	21731347
Are sedatives and hypnotics associated with increased suicide risk of suicide in the elderly?	2009-06-04	19497093
Treatment of schizophrenia with antipsychotics in Norwegian emergency wards, a cross-sectional national study.	2009-05-16	19445700
Maternal use of antipsychotics in early pregnancy and delivery outcome.	2008-06	18480684
Preoperative sub-Tenon's capsule injection of ropivacaine in conjunction with general anesthesia in retinal detachment surgery.	2007-11	17445898
A two-year prospective study comparing lidocaine 2% jelly versus peribulbar anaesthesia for 25G and 23G sutureless vitrectomy.	2007-09	17342504
Relationships between free radical levels during carotid endarterectomy and markers of arteriosclerotic disease.	2007-04-14	17505560
Dixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.	2004-11	15504190
Disturbing post-operative symptoms are not reduced by prophylactic antiemetic treatment in patients at high risk of post-operative nausea and vomiting.	2004-07	15196110
Wound infiltration with ropivacaine and fentanyl: effects on postoperative pain and PONV after breast surgery.	2003-03	12719050
Topical anesthesia for cataract surgery: a population-based perspective.	2001-03	11255059

Sample Use Guides

In Vivo Use Guide

The oral dose of dixyrazine ranges from 20 to 75 mg daily. Dixyrazine has also been given by intramuscular injection at 0.5 mg/kg

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:38:13 GMT 2025` Edited by `admin` on `Mon Mar 31 18:38:13 GMT 2025`
Record UNII	1N4Y3TZ2PC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIXYRAZINE DIHYDROCHLORIDE

Common Name

English

NSC-169095

Preferred Name

English

ETHANOL, 2-(2-(4-(2-METHYL-3-(10H-PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINYL)ETHOXY)-, HYDROCHLORIDE (1:2)

Systematic Name

English

DIXYRAZINE DIHYDROCHLORIDE [MI]

Common Name

English

Code System Code Type Description

MERCK INDEX

m4699