DIXYRAZINE DIHYDROCHLORIDE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C24H33N3O2S.2ClH
Molecular Weight	500.525
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.CC(CN1CCN(CCOCCO)CC1)CN2C3=C(SC4=C2C=CC=C4)C=CC=C3

InChI

InChIKey=PZYZOXQAAJBNOK-UHFFFAOYSA-N

InChI=1S/C24H33N3O2S.2ClH/c1-20(18-26-12-10-25(11-13-26)14-16-29-17-15-28)19-27-21-6-2-4-8-23(21)30-24-9-5-3-7-22(24)27;;/h2-9,20,28H,10-19H2,1H3;2*1H

HIDE SMILES / InChI

Molecular Formula	C24H33N3O2S
Molecular Weight	427.603
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugfuture.com/mt/difebarbamate.pdf | https://www.ncbi.nlm.nih.gov/pubmed/3348073

Dixyrazine is a typical antipsychotic of the phenothiazine group. Under a trademark Esucos, the drug was used in European countries as an antipsychotic, antiemetic and sedative with oral doses ranging from 20 to 75 mg daily. Dixyrazine has also been given by injection.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Disturbing post-operative symptoms are not reduced by prophylactic antiemetic treatment in patients at high risk of post-operative nausea and vomiting.	2004 Jul	15196110
Dixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.	2004 Nov	15504190
Maternal use of antipsychotics in early pregnancy and delivery outcome.	2008 Jun	18480684
Treatment of schizophrenia with antipsychotics in Norwegian emergency wards, a cross-sectional national study.	2009 May 16	19445700

Sample Use Guides

In Vivo Use Guide

The oral dose of dixyrazine ranges from 20 to 75 mg daily. Dixyrazine has also been given by intramuscular injection at 0.5 mg/kg

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:56:11 GMT 2023` Edited by `admin` on `Fri Dec 15 16:56:11 GMT 2023`
Record UNII	1N4Y3TZ2PC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIXYRAZINE DIHYDROCHLORIDE

Common Name

English

ETHANOL, 2-(2-(4-(2-METHYL-3-(10H-PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINYL)ETHOXY)-, HYDROCHLORIDE (1:2)

Systematic Name

English

NSC-169095

Code

English

DIXYRAZINE DIHYDROCHLORIDE [MI]

Common Name

English

Code System Code Type Description

MERCK INDEX

m4699