POTASSIUM BISULFATE

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	K.HO4S
Molecular Weight	136.169
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[K+].OS([O-])(=O)=O

InChI

InChIKey=CHKVPAROMQMJNQ-UHFFFAOYSA-M

InChI=1S/K.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+1;/p-1

HIDE SMILES / InChI

Molecular Formula	K
Molecular Weight	39.0983
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HO4S
Molecular Weight	97.071
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022372s004lbledt.pdf | https://www.webmd.com/drugs/2/drug-154631/suprep-bowel-prep-kit-oral/details

SULFATE (as sodium sulfate, potassium sulfate, and magnesium sulfate) is a component of SUPREP Bowel Prep Kit. It is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults. Sulfate salts provide sulfate anions, which are poorly absorbed. The osmotic effect of unabsorbed sulfate anions and the associated cations causes water to be retained within the gastrointestinal tract. SUPREP Bowel Prep Kit, when ingested with a large volume of water, produces copious watery diarrhea.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bowel Cleanser 7 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022372s004lbledt.pdf	Palliative		Approved 8429	SUPREP Bowel Prep Kit Approved Use SUPREP Bowel Prep Kit is an osmotic laxative indicated for cleansing of the colon in preparation for colonoscopy in adults. Launch Date 2010

PubMed

Title	Date	PubMed
Management of autonomic dysfunction in severe tetanus: the use of magnesium sulphate and clonidine.	1990	2094230
Sodium dodecyl sulphate electrophoresis of urinary proteins.	1991 Sep 13	1939488
Patterns of sulphation in heparan sulphate: polymorphism based on a common structural theme.	1992 Apr	1516727
Heparan sulphate in the binding and activation of basic fibroblast growth factor.	1992 Dec	1472758
Death by tanning--a case of fatal basic chromium sulphate poisoning.	1994	8201096
Keratan sulphate--a 'reserve' polysaccharide?	1994 Apr	8038262
Renal and small intestinal sodium-dependent symporters of phosphate and sulphate.	1994 Nov	7823020
Dextran sulphate induces a PKC and actin independent internalisation of CD4.	1994 Sep	7829123
The osmotic and intrinsic mechanisms of the pharmacological laxative action of oral high doses of magnesium sulphate. Importance of the release of digestive polypeptides and nitric oxide.	1996 Jun	8878010
Two selectins converge on sulphate. Leukocyte adhesion.	1996 Mar 1	8805242
The role of stromal cell heparan sulphate in regulating haemopoiesis.	1996 May	9172804
Dehydroepiandrosterone, dehydroepiandrosterone sulphate and cardiovascular disease.	1996 Sep	8943798
Heparan sulphate.	1997 May	9251237
Structure-activity relationship of heparan sulphate.	1997 Nov	9449976
Heparan sulphate proteoglycan and wound healing in skin.	1997 Nov	9422978
Dermatan sulphate as an antithrombotic drug.	2002 Sep-Dec	13679662
Magnesium sulphate versus phenytoin for eclampsia.	2003	14583911
Magnesium sulphate versus diazepam for eclampsia.	2003	14583910
Magnesium sulphate and other anticonvulsants for women with pre-eclampsia.	2003	12804383
Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders.	2003 Aug	12878436
Are low dehydroepiandrosterone sulphate levels predictive for cardiovascular diseases? A review of prospective and retrospective studies.	2003 Oct	14609305
Characterization of the Herpesvirus saimiri Orf51 protein.	2004 Aug 15	15262496
The SLC13 gene family of sodium sulphate/carboxylate cotransporters.	2004 Feb	12915942
Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS?	2004 Jan	14690476
Molecular recognition by LARGE is essential for expression of functional dystroglycan.	2004 Jun 25	15210115
[The extracellular matrix of the central nervous system: chondroitin sulphate type proteoglycans and neural repair].	2004 May 1-15	15152354
Epidemiology of 377 patients with chemical burns in Guangdong province.	2004 Sep	15302423
Biotechnological engineering of heparin/heparan sulphate: a novel area of multi-target drug discovery.	2005	16026302
Evidence and practice: the magnesium sulphate story.	2005 Feb	15749066
A meta-analysis on intravenous magnesium sulphate for treating acute asthma.	2005 Jan	15613519
Heparan sulphate proteoglycans: the sweet side of development.	2005 Jul	16072037
A review of the role for magnesium sulphate in preterm labour.	2005 Mar	15715602
Chondroitin sulphate: antioxidant properties and beneficial effects.	2006 Dec	17168807
Heparan sulphate proteoglycans and viral vectors : ally or foe?	2006 Feb	16475944
[Magnesium sulphate for the management of preeclampsia].	2006 Jan	16406662
Interferon and heparan sulphate.	2006 Jun	16709188
Heparin/heparan sulphate binding in the TGF-beta cytokine superfamily.	2006 Jun	16709187
Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment.	2006 Jun	16709185
The role of heparan sulphate proteoglycans in angiogenesis.	2006 Jun	16709184
Insights into the role of heparan sulphate in fibroblast growth factor signalling.	2006 Jun	16709182
Multiprotein signalling complexes: regional assembly on heparan sulphate.	2006 Jun	16709181
Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors.	2006 Jun	16709175
Dietary acidification enhances phosphorus digestibility but decreases H+/K+-ATPase expression in rainbow trout.	2006 Oct	16985189
The role of heparan sulphate in inflammation.	2006 Sep	16917509
Overcoming chondroitin sulphate proteoglycan inhibition of axon growth in the injured brain: lessons from chondroitinase ABC.	2007	17692016
[Therapy of osteoarthritis crystalline glucosamine sulphate/a review of the clinical effcacy].	2007	17515291
Heparan sulphate proteoglycans fine-tune mammalian physiology.	2007 Apr 26	17460664
Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus.	2007 Jul 18	17636771
Evaluation of formocresol versus ferric sulphate primary molar pulpotomy: a systematic review and meta-analysis.	2007 Oct	17714467
Cholesterol sulfate as a potential inhibitor of hepatitis C virus NS3 helicase.	2014 Apr	23432541

Patents

Sample Use Guides

In Vivo Use Guide

Split-Dose (2-Day) Regimen: The evening before colonoscopy: dilute one bottle with water to a total volume of 16 oz. (up to the fill line) and drink the entire amount. Drink 32 ounces of water over the next hour. Next morning: repeat both steps using the second bottle. Complete preparation at least 2 hours before colonoscopy or as directed by a physician.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 21:18:12 GMT 2023` Edited by `admin` on `Fri Dec 15 21:18:12 GMT 2023`
Record UNII	1J1K03241F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

POTASSIUM BISULFATE

Systematic Name

English

POTASSIUM BISULFATE [MI]

Common Name

English

POTASSIUM HYDROGEN SULFATE

Systematic Name

English

NSC-409996

Code

English

MONOPOTASSIUM SULFATE

Systematic Name

English

SAL ENIXUM

Common Name

English

POTASSIUM ACID SULFATE

Common Name

English

HYDROGEN POTASSIUM SULFATE

Common Name

English

ACID POTASSIUM SULFATE

Common Name

English

INS-515(II)

Code

English

SULFURIC ACID, MONOPOTASSIUM SALT

Common Name

English

E-515(II)

Code

English

INS NO.515(II)

Code

English

Classification Tree Code System Code

CODEX ALIMENTARIUS (GSFA)

INS-515(II)