EPROXINDINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C23H29N3O3.ClH
Molecular Weight	431.956
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0
Stereo Comments	Assumed racemic

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCN(CC)CC(O)CNC(=O)C1=C(OC)C2=C(C=CC=C2)N1C3=CC=CC=C3

InChI

InChIKey=QFDGNFAPAMWAAM-UHFFFAOYSA-N

InChI=1S/C23H29N3O3.ClH/c1-4-25(5-2)16-18(27)15-24-23(28)21-22(29-3)19-13-9-10-14-20(19)26(21)17-11-7-6-8-12-17;/h6-14,18,27H,4-5,15-16H2,1-3H3,(H,24,28);1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C23H29N3O3
Molecular Weight	395.4947
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://link.springer.com/chapter/10.1007%2F978-1-4757-2085-3_5 | https://www.ncbi.nlm.nih.gov/pubmed/2435614/ | https://www.ncbi.nlm.nih.gov/m/pubmed/6099302/

Eproxindine (KC 3791) is an antiarrythmic. It is able to inactivate voltage-dependent sodium channels. Eproxindine also proved to be capable of blocking open potassium channels at outwardly directed potassium currents

Approval Year

PubMed

Title	Date	PubMed
The role of inactivation in the cumulative blockage of voltage-dependent sodium channels by local anesthetics and antiarrythmics.	1984 Dec	6099302
Use-dependent blockade of sodium channels by local anaesthetics and antiarrhythmic drugs. Effects of chloramine-T and calcium ions.	1986	2431852
Effects of KC 3791 on sodium and potassium channels in frog node of Ranvier.	1986 Dec	2435614
Determination of eproxindine hydrochloride in human plasma by capillary gas chromatography.	1988 May 13	3410896

Patents

Sample Use Guides

In Vitro Use Guide

Eproxindine (KC 3791) When applied externally to the node of Ranvier, KC 3791 (KC) at concentrations of 10-100 uM produced both tonic and cumulative (use-dependent) inhibition of sodium currents.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:05:57 GMT 2023` Edited by `admin` on `Fri Dec 15 15:05:57 GMT 2023`
Record UNII	1H0DBU29HS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

EPROXINDINE HYDROCHLORIDE

Common Name

English

KC-3791

Code

English

1H-INDOLE-2-CARBOXAMIDE, N-(3-(DIETHYLAMINO)-2-HYDROXYPROPYL)-3-METHOXY-1-PHENYL-, HYDROCHLORIDE (1:1)

Systematic Name

English

Code System Code Type Description

PUBCHEM

158872

Created by admin on Fri Dec 15 15:05:57 GMT 2023 , Edited by admin on Fri Dec 15 15:05:57 GMT 2023

PRIMARY

FDA UNII

1H0DBU29HS

Created by admin on Fri Dec 15 15:05:57 GMT 2023 , Edited by admin on Fri Dec 15 15:05:57 GMT 2023

PRIMARY

EPA CompTox

DTXSID801006380

Created by admin on Fri Dec 15 15:05:57 GMT 2023 , Edited by admin on Fri Dec 15 15:05:57 GMT 2023

PRIMARY

CAS

85793-72-2

Created by admin on Fri Dec 15 15:05:57 GMT 2023 , Edited by admin on Fri Dec 15 15:05:57 GMT 2023

PRIMARY

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					E229K2HE7F

EPROXINDINE

ACTIVE MOIETY

Details

SMILES

InChI

DescriptionSources: https://link.springer.com/chapter/10.1007%2F978-1-4757-2085-3_5 | https://www.ncbi.nlm.nih.gov/pubmed/2435614/ | https://www.ncbi.nlm.nih.gov/m/pubmed/6099302/

Approval Year

PubMed

Patents

Sample Use Guides

Description
Sources: https://link.springer.com/chapter/10.1007%2F978-1-4757-2085-3_5 | https://www.ncbi.nlm.nih.gov/pubmed/2435614/ | https://www.ncbi.nlm.nih.gov/m/pubmed/6099302/