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Details

Stereochemistry RACEMIC
Molecular Formula C23H29N3O3.ClH
Molecular Weight 431.956
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0
Stereo Comments Assumed racemic

SHOW SMILES / InChI
Structure of EPROXINDINE HYDROCHLORIDE

SMILES

Cl.CCN(CC)CC(O)CNC(=O)C1=C(OC)C2=C(C=CC=C2)N1C3=CC=CC=C3

InChI

InChIKey=QFDGNFAPAMWAAM-UHFFFAOYSA-N
InChI=1S/C23H29N3O3.ClH/c1-4-25(5-2)16-18(27)15-24-23(28)21-22(29-3)19-13-9-10-14-20(19)26(21)17-11-7-6-8-12-17;/h6-14,18,27H,4-5,15-16H2,1-3H3,(H,24,28);1H

HIDE SMILES / InChI
Molecular Formula C23H29N3O3
Molecular Weight 395.4947
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Eproxindine (KC 3791) is an antiarrythmic. It is able to inactivate voltage-dependent sodium channels. Eproxindine also proved to be capable of blocking open potassium channels at outwardly directed potassium currents

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Determination of eproxindine hydrochloride in human plasma by capillary gas chromatography.
1988-05-13
Effects of KC 3791 on sodium and potassium channels in frog node of Ranvier.
1986-12
Use-dependent blockade of sodium channels by local anaesthetics and antiarrhythmic drugs. Effects of chloramine-T and calcium ions.
1986
The role of inactivation in the cumulative blockage of voltage-dependent sodium channels by local anesthetics and antiarrythmics.
1984-12
Patents

Patents

20100226943
186

Sample Use Guides

In Vitro Use Guide
Eproxindine (KC 3791) When applied externally to the node of Ranvier, KC 3791 (KC) at concentrations of 10-100 uM produced both tonic and cumulative (use-dependent) inhibition of sodium currents.
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:46:24 GMT 2025
Edited
by admin
on Mon Mar 31 17:46:24 GMT 2025
Record UNII
1H0DBU29HS
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
KC-3791
Preferred Name English
EPROXINDINE HYDROCHLORIDE
Common Name English
1H-INDOLE-2-CARBOXAMIDE, N-(3-(DIETHYLAMINO)-2-HYDROXYPROPYL)-3-METHOXY-1-PHENYL-, HYDROCHLORIDE (1:1)
Systematic Name English
Code System Code Type Description
PUBCHEM
158872
Created by admin on Mon Mar 31 17:46:24 GMT 2025 , Edited by admin on Mon Mar 31 17:46:24 GMT 2025
PRIMARY
FDA UNII
1H0DBU29HS
Created by admin on Mon Mar 31 17:46:24 GMT 2025 , Edited by admin on Mon Mar 31 17:46:24 GMT 2025
PRIMARY
EPA CompTox
DTXSID801006380
Created by admin on Mon Mar 31 17:46:24 GMT 2025 , Edited by admin on Mon Mar 31 17:46:24 GMT 2025
PRIMARY
CAS
85793-72-2
Created by admin on Mon Mar 31 17:46:24 GMT 2025 , Edited by admin on Mon Mar 31 17:46:24 GMT 2025
PRIMARY
Related Record Type Details
Structure of EPROXINDINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of EPROXINDINE
ACTIVE MOIETY
NIH
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