U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 17:28:37 GMT 2023
Edited
by admin
on Sat Dec 16 17:28:37 GMT 2023
Protein Type BISPECIFIC ANTIBODY
Protein Sub Type IGG1
Sequence Type COMPLETE
Record UNII
1GK8Z1OT1R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Forimtamig
USAN   INN  
Official Name English
RO-7425781
Code English
RO7425781
Code English
FORIMTAMIG [USAN]
Common Name English
RG6234
Code English
RG-6234
Code English
Immunoglobulin G1 [459-alanine,460-alanine,579-cysteine,554-glycine,591-tryptophan], anti-(human G protein-coupled receptor GPRC5D) (human-Rattus norvegicus γ1-chain N-terminal fragment) fusion protein with peptide linker (GGGGS)2 fusion protein with im
Common Name English
forimtamig [INN]
Common Name English
Immunoglobulin G1-lambda/kappa with crossed domains, anti-[Homo sapiens GPRC5D (G proteincoupled receptor class C group 5 member D)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], humanized monoclonal antibody, bispecific, trivalent; gamma-lambda hea
Common Name English
Code System Code Type Description
CAS
2649379-96-2
Created by admin on Sat Dec 16 17:28:37 GMT 2023 , Edited by admin on Sat Dec 16 17:28:37 GMT 2023
PRIMARY
FDA UNII
1GK8Z1OT1R
Created by admin on Sat Dec 16 17:28:37 GMT 2023 , Edited by admin on Sat Dec 16 17:28:37 GMT 2023
PRIMARY
NCI_THESAURUS
C189961
Created by admin on Sat Dec 16 17:28:37 GMT 2023 , Edited by admin on Sat Dec 16 17:28:37 GMT 2023
PRIMARY
USAN
LM-143
Created by admin on Sat Dec 16 17:28:37 GMT 2023 , Edited by admin on Sat Dec 16 17:28:37 GMT 2023
PRIMARY
INN
12346
Created by admin on Sat Dec 16 17:28:37 GMT 2023 , Edited by admin on Sat Dec 16 17:28:37 GMT 2023
PRIMARY
From To
1_445 3_232
2_220 5_218
5_138 5_198
5_23 5_92
1_220 4_218
4_138 4_198
4_23 4_92
3_152 3_212
3_22 3_98
1_579 2_349
2_367 2_425
2_261 2_321
2_144 2_200
2_22 2_96
1_592 1_650
1_486 1_546
1_369 1_425
1_253 1_321
1_144 1_200
1_22 1_96
1_454 2_229
1_451 2_226
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_522
N 2_297
Related Record Type Details
TARGET->LIGAND
IN-VITRO
TARGET->LIGAND
IN-VITRO
Related Record Type Details
ACTIVE MOIETY
Target-cell-dependent T-cell cytotoxicity; T-cell activation, proliferation, and cytokine release in tumor cell lysis assays only in the presence of GPRC5D-expressing target cells
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL