Forimtamig

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 09:12:41 GMT 2025` Edited by `admin` on `Wed Apr 02 09:12:41 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	1GK8Z1OT1R
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Forimtamig

Official Name

English

RG-6234

Preferred Name

English

RO-7425781

Code

English

RO7425781

Code

English

FORIMTAMIG [USAN]

Common Name

English

RG6234

Code

English

Forimtamig [WHO-DD]

Common Name

English

Immunoglobulin G1 [459-alanine,460-alanine,579-cysteine,554-glycine,591-tryptophan], anti-(human G protein-coupled receptor GPRC5D) (human-Rattus norvegicus ?1-chain N-terminal fragment) fusion protein with peptide linker (GGGGS)2 fusion protein with imm

Common Name

English

forimtamig [INN]

Common Name

English

Immunoglobulin G1-lambda/kappa with crossed domains, anti-[Homo sapiens GPRC5D (G proteincoupled receptor class C group 5 member D)] and anti-[Homo sapiens CD3E (CD3 epsilon, Leu-4)], humanized monoclonal antibody, bispecific, trivalent; gamma-lambda hea

Common Name

English

Code System Code Type Description

CAS

2649379-96-2

Created by admin on Wed Apr 02 09:12:41 GMT 2025 , Edited by admin on Wed Apr 02 09:12:41 GMT 2025

PRIMARY

FDA UNII

1GK8Z1OT1R

Created by admin on Wed Apr 02 09:12:41 GMT 2025 , Edited by admin on Wed Apr 02 09:12:41 GMT 2025

PRIMARY

SMS_ID

300000023634

Created by admin on Wed Apr 02 09:12:41 GMT 2025 , Edited by admin on Wed Apr 02 09:12:41 GMT 2025

PRIMARY

NCI_THESAURUS

C189961

Created by admin on Wed Apr 02 09:12:41 GMT 2025 , Edited by admin on Wed Apr 02 09:12:41 GMT 2025

PRIMARY

USAN

LM-143

Created by admin on Wed Apr 02 09:12:41 GMT 2025 , Edited by admin on Wed Apr 02 09:12:41 GMT 2025

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INN

12346

Created by admin on Wed Apr 02 09:12:41 GMT 2025 , Edited by admin on Wed Apr 02 09:12:41 GMT 2025

PRIMARY

From	To
1_445	3_232
2_220	5_218
5_138	5_198
5_23	5_92
1_220	4_218
4_138	4_198
4_23	4_92
3_152	3_212
3_22	3_98
1_579	2_349
2_367	2_425
2_261	2_321
2_144	2_200
2_22	2_96
1_592	1_650
1_486	1_546
1_369	1_425
1_253	1_321
1_144	1_200
1_22	1_96
1_454	2_229
1_451	2_226

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_522
N	2_297

Related Record Type Details


					5N4BM61CX9

G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER D

TARGET->LIGAND

Interaction Type:

IN-VITRO

Amount:


					ZLW14X2D30

CD3

TARGET->LIGAND

Interaction Type:

IN-VITRO

Amount:

Related Record Type Details


					1GK8Z1OT1R

ACTIVE MOIETY

Comments:

Target-cell-dependent T-cell cytotoxicity; T-cell activation, proliferation, and cytokine release in tumor cell lysis assays only in the presence of GPRC5D-expressing target cells

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_672] [2_447]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL