Fanastomig

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 07:34:41 GMT 2025` Edited by `admin` on `Wed Apr 02 07:34:41 GMT 2025`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	1GCR6YY9NI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Immunoglobulin L-kappa-H-gamma1_G1(VH-CH1-h)_L-kappa dimer, anti-[Homo sapiens LAG3 (lymphocyte activating 3, lymphocyte-activation 3, CD223)] and anti-[Homo sapiens PDCD1 (programmed cell death 1, PD-1, PD1, CD279)], monoclonal antibody, bispecific

Preferred Name

English

Fanastomig

Official Name

English

fanastomig [INN]

Common Name

English

[L-kappa-H-gamma1 heavy chain anti-LAG3 and anti-PDCD1 (1-665) [L-kappa anti-LAG3 (1-214) [V-KAPPA Musmus/Homsap (Mus musculus IGKV9-124*01 (88.4%) -IGKJ5*01 (91.7%) A120>Q (100)/Homo sapiens IGKV1-16*01 (84.2%) -IGKJ2*01 (90.9%) I126>L (106), CDR-IMGT [

Common Name

English

Code System Code Type Description

CAS

2761795-00-8

Created by admin on Wed Apr 02 07:34:41 GMT 2025 , Edited by admin on Wed Apr 02 07:34:41 GMT 2025

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INN

12694

Created by admin on Wed Apr 02 07:34:41 GMT 2025 , Edited by admin on Wed Apr 02 07:34:41 GMT 2025

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NCI_THESAURUS

C203056

Created by admin on Wed Apr 02 07:34:41 GMT 2025 , Edited by admin on Wed Apr 02 07:34:41 GMT 2025

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SMS_ID

300000055867

Created by admin on Wed Apr 02 07:34:41 GMT 2025 , Edited by admin on Wed Apr 02 07:34:41 GMT 2025

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FDA UNII

1GCR6YY9NI

Created by admin on Wed Apr 02 07:34:41 GMT 2025 , Edited by admin on Wed Apr 02 07:34:41 GMT 2025

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From	To
6_134	6_194
6_23	6_88
5_134	5_194
5_23	5_88
4_140	4_196
4_22	4_96
3_140	3_196
3_22	3_96
2_585	2_643
2_479	2_539
2_438	6_214
2_362	2_418
2_236	2_310
2_214	4_216
2_134	2_194
2_23	2_88
1_585	1_643
1_479	1_539
1_447	2_447
1_444	2_444
1_438	5_214
1_362	1_418
1_236	1_310
1_214	3_216
1_134	1_194
1_23	1_88

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_515
N	2_515

Related Record Type Details


					1GCR6YY9NI

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_665] [2_665]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL