ALMURTIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H30N4O11
Molecular Weight	478.451
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H](NC(=O)CO[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O)C(=O)N[C@H](CCC(O)=O)C(N)=O

InChI

InChIKey=NWMHDZMRVUOQGL-CZEIJOLGSA-N

InChI=1S/C18H30N4O11/c1-8(18(32)22-10(17(19)31)3-4-14(28)29)20-13(27)7-33-16(15(30)12(26)6-24)11(5-23)21-9(2)25/h5,8,10-12,15-16,24,26,30H,3-4,6-7H2,1-2H3,(H2,19,31)(H,20,27)(H,21,25)(H,22,32)(H,28,29)/t8-,10+,11-,12+,15+,16+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C18H30N4O11
Molecular Weight	478.451
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 6
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C81667 | https://www.ncbi.nlm.nih.gov/pubmed/3867329

Almurtide (CGP 11637) is a synthetic muramyl dipeptide (MDP) analogue with potential immunostimulating and antineoplastic activity. As a derivative of the mycobacterial cell wall component MDP, almurtide activates both monocytes and macrophages. This results in the secretion of cytokines and induces the recruitment and activation of other immune cells, which may result in indirect tumoricidal or cytostatic effects. CGP 11637 has been shown to prevent oncogenic viral infections in mice.

Approval Year

PubMed

Title	Date	PubMed
Prevention of oncogenic viral infections in mice with CGP 11637, a synthetic muramyl dipeptide analog.	1985-11	3867329

Patents

Sample Use Guides

In Vivo Use Guide

Mice were injected with 100 ug of Almurtide s.c. at 1-to 2-month intervals

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:18:48 GMT 2025` Edited by `admin` on `Mon Mar 31 18:18:48 GMT 2025`
Record UNII	1DCO35D4OR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

almurtide [INN]

Preferred Name

English

ALMURTIDE

Official Name

English

CGP-11637

Code

English

2-ACETAMIDO-3-O-((((1S)-1-(((1R)-1-CARBAMOYL-3-CARBOXYPROPYL)CARBAMOYL)ETHYL)CARBAMOYL)METHYL)-2-DEOXY-D-GLUCOPYRANOSE

Systematic Name

English

(4R,5R,10S,13R)-13-CARBAMOYL-4-FORMYL-10-METHYL-2,8,11-TRIOXO-5-((1R,2R)-1,2,3-TRIHYDROXYPROPYL)-6-OXA-3,9,12-TRIAZAHEXADECAN-16-OIC ACID

Systematic Name

English

(4R)-4-((2S)-2-(2-(((3R,4R,5S,6R)-3-ACETAMIDO-2,5-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-4-YL)OXY)ACETAMIDO)PROPANAMIDO)-5-AMINO-5-OXOPENTANOIC ACID

Systematic Name

English

D-.ALPHA.-GLUTAMINE, N-(N-ACETYLNORMURAMOYL)-L-ALANYL-

Systematic Name

English

NORMDP

Code

English

N-ACETYLNORMURAMOYL-L-ALANYL-D-ISOGLUTAMINE

Common Name

English

NORMURAMYLDIPEPTIDE

Common Name

English

Nor-MDP

Common Name

English

N-ACETYLDESMETHYLMURAMOYL-L-ALANYL-D-ISOGLUTAMINE

Common Name

English

DESMETHYLMURAMOYLDIPEPTIDE

Common Name

English

N-(N-ACETYLNORMURAMOYL)-L-ALANYL-D-.ALPHA.-GLUTAMINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C129820