Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H35N3O4S |
| Molecular Weight | 401.564 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)C=O
InChI
InChIKey=RJWLAIMXRBDUMH-ULQDDVLXSA-N
InChI=1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
| Molecular Formula | C19H35N3O4S |
| Molecular Weight | 401.564 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: P07858 Gene ID: 1508.0 Gene Symbol: CTSB Target Organism: Homo sapiens (Human) |
100.0 nM [Ki] | ||
Target ID: P07384 Gene ID: 823.0 Gene Symbol: CAPN1 Target Organism: Homo sapiens (Human) |
120.0 nM [Ki] | ||
Target ID: P17655 Gene ID: 824.0 Gene Symbol: CAPN2 Target Organism: Homo sapiens (Human) |
230.0 nM [Ki] | ||
Target ID: P07711 Gene ID: 1514.0 Gene Symbol: CTSL Target Organism: Homo sapiens (Human) |
0.6 nM [Ki] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
| Title | Date | PubMed |
|---|---|---|
| Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. | 1990 |
|
| The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2000 Nov 17 |
|
| Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. | 2004 Feb |
Sample Use Guides
Calpain-mediated membrane-derived microparticles biogenesis is the dominant pathway at rest in malignant cells as vesiculation was shown to be inhibited with calpain inhibitor II (ALLM). This study examined the differences in vesiculation between malignant and non-malignant cells using high-resolution Atomic Force Microscopy (AFM). HBEC, MBE-F, MCF-7, and MCF- 7/Dx cells were analysed at rest and following treatment with calcium ionophore A23187 for 18 hours. Vesiculation of calcium activated and resting malignant and non-malignant cells was also assessed after 18 hour treatment of calpain inhibitor II (ALLM).
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:17:47 GMT 2023
by
admin
on
Fri Dec 15 18:17:47 GMT 2023
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| Record UNII |
1D8SBU367Z
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| Record Status |
Validated (UNII)
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| Record Version |
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121855
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1D8SBU367Z
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DTXSID90911499
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110115-07-6
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admin on Fri Dec 15 18:17:47 GMT 2023 , Edited by admin on Fri Dec 15 18:17:47 GMT 2023
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