Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H22N6O4 |
| Molecular Weight | 446.4586 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=NC(=O)C2=C(N1)N([C@H]3C[C@H](O)[C@@H](CO)O3)C(NC4=CC=C5C(CC6=CC=CC=C56)=C4)=N2
InChI
InChIKey=RMYQNJYFBAYPNG-RCCFBDPRSA-N
InChI=1S/C23H22N6O4/c24-22-27-20-19(21(32)28-22)26-23(29(20)18-9-16(31)17(10-30)33-18)25-13-5-6-15-12(8-13)7-11-3-1-2-4-14(11)15/h1-6,8,16-18,30-31H,7,9-10H2,(H,25,26)(H3,24,27,28,32)/t16-,17+,18+/m0/s1
| Molecular Formula | C23H22N6O4 |
| Molecular Weight | 446.4586 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene. | 2008-03 |
|
| Probing the thermodynamics of aminofluorene-induced translesion DNA synthesis by differential scanning calorimetry. | 2007-10-10 |
|
| Examination of the long-range effects of aminofluorene-induced conformational heterogeneity and its relevance to the mechanism of translesional DNA synthesis. | 2007-03-09 |
|
| Conformation-specific recognition of carcinogen-DNA adduct in escherichia coli nucleotide excision repair. | 2007-01 |
|
| Mutagenic properties of 3-(deoxyguanosin-N2-yl)-2-acetylaminofluorene, a persistent acetylaminofluorene-derived DNA adduct in mammalian cells. | 2004-11-30 |
|
| Mutagenic events in Escherichia coli and mammalian cells generated in response to acetylaminofluorene-derived DNA adducts positioned in the Nar I restriction enzyme site. | 2002-12-03 |
|
| Translesional synthesis past acetylaminofluorene-derived DNA adducts catalyzed by human DNA polymerase kappa and Escherichia coli DNA polymerase IV. | 2001-12-18 |
|
| 1Alpha,25-dihydroxyvitamin D3 inhibits hepatic chromosomal aberrations, DNA strand breaks and specific DNA adducts during rat hepatocarcinogenesis. | 2001-07 |
|
| Influence of flanking sequence context on the mutagenicity of acetylaminofluorene-derived DNA adducts in mammalian cells. | 2001-03-27 |
|
| Gene- and tissue-specificity of mutation in Big Blue rats treated with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene. | 2001 |
|
| Comparison of hprt and lacI mutant frequency with DNA adduct formation in N-hydroxy-2-acetylaminofluorene-treated Big Blue rats. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:09:44 GMT 2025
by
admin
on
Mon Mar 31 19:09:44 GMT 2025
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| Record UNII |
1D7E8EIA7K
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| Record Status |
Validated (UNII)
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| Record Version |
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