Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H20ClN3O |
| Molecular Weight | 353.845 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC[C@@H](C)N(C)C(=O)C1=NC2=C(C=CC=C2)C(=N1)C3=C(Cl)C=CC=C3
InChI
InChIKey=ASFLYNMYGAYKON-CYBMUJFWSA-N
InChI=1S/C20H20ClN3O/c1-4-13(2)24(3)20(25)19-22-17-12-8-6-10-15(17)18(23-19)14-9-5-7-11-16(14)21/h5-13H,4H2,1-3H3/t13-/m1/s1
| Molecular Formula | C20H20ClN3O |
| Molecular Weight | 353.845 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
ER176 ((R)-N-sec-butyl-4-(2-chlorophenyl)-N-methylquinazoline-2-carboxamide) is a ligand of mitochondrial 18-kDa translocator protein (TSPO). TSPO is a mitochondrial protein that is highly expressed in phagocytic inflammatory cells, including activated microglia in the brain and macrophages in the periphery. 11C-radiolabeled ER176 is a promising PET tracer for imaging of neuroinflammation.
Originator
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:44:38 GMT 2023
by
admin
on
Sat Dec 16 09:44:38 GMT 2023
|
| Record UNII |
1CFA2S833A
|
| Record Status |
Validated (UNII)
|
| Record Version |
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-
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1CFA2S833A
Created by
admin on Sat Dec 16 09:44:38 GMT 2023 , Edited by admin on Sat Dec 16 09:44:38 GMT 2023
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57521383
Created by
admin on Sat Dec 16 09:44:38 GMT 2023 , Edited by admin on Sat Dec 16 09:44:38 GMT 2023
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1373887-29-6
Created by
admin on Sat Dec 16 09:44:38 GMT 2023 , Edited by admin on Sat Dec 16 09:44:38 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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LABELED -> NON-LABELED |
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