Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H36N2O4.C4H4O4 |
| Molecular Weight | 508.6044 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)\C=C/C(O)=O.CC(C)(N)CNC(=O)C[C@H]1CC[C@]2(CC1)OOC3(O2)C4CC5CC(C4)CC3C5
InChI
InChIKey=SVDSPJJUJMMDFX-CXCXETQFSA-N
InChI=1S/C22H36N2O4.C4H4O4/c1-20(2,23)13-24-19(25)12-14-3-5-21(6-4-14)26-22(28-27-21)17-8-15-7-16(10-17)11-18(22)9-15;5-3(6)1-2-4(7)8/h14-18H,3-13,23H2,1-2H3,(H,24,25);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15?,16?,17?,18?,21+,22?;
| Molecular Formula | C4H4O4 |
| Molecular Weight | 116.0722 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
| Molecular Formula | C22H36N2O4 |
| Molecular Weight | 392.5322 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Arterolane is an anti-malarial drug developed by Ranbaxy Laboratories. Arterolane belongs to peroxidic antimalarial compounds. Upon administration, the drug is activated by heme of hemoglobin digested by malarial parasite. Activation produces free radicals, leading to alkylation of heme and proteins, critical for the survival of the parasite. Arterolane was approved for marketing in India in 2012 and received marketing authorization in several African countries in 2014.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Identification of an antimalarial synthetic trioxolane drug development candidate. | 2004 Aug 19 |
|
| [Artemisinin and successors]. | 2005 |
|
| In vitro susceptibility of P. falciparum populations from Colombia and Tanzania to a new synthetic peroxide (OZ277). | 2007 Jun |
|
| Development and validation of a headspace gas chromatographic method for the determination of residual solvents in arterolane (RBx11160) maleate bulk drug. | 2010 Jan |
|
| The structure-activity relationship of the antimalarial ozonide arterolane (OZ277). | 2010 Jan 14 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 15:04:37 GMT 2023
by
admin
on
Sat Dec 16 15:04:37 GMT 2023
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| Record UNII |
1C86ZU1OEN
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| Record Status |
Validated (UNII)
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| Record Version |
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1C86ZU1OEN
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300000039291
Created by
admin on Sat Dec 16 15:04:37 GMT 2023 , Edited by admin on Sat Dec 16 15:04:37 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |