ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 20:13:38 GMT 2025` Edited by `admin` on `Tue Apr 01 20:13:38 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	1B37H0967P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1

Common Name

English

BASIC-HELIX-LOOP-HELIX-PAS PROTEIN MOP2

Preferred Name

English

HIF-2-ALPHA

Common Name

English

MOP2

Common Name

English

PASD2

Common Name

English

HIF2-ALPHA

Common Name

English

HIF2A

Common Name

English

MEMBER OF PAS PROTEIN 2

Common Name

English

HYPOXIA-INDUCIBLE FACTOR 2-ALPHA

Common Name

English

HLF

Common Name

English

HIF-1-ALPHA-LIKE FACTOR

Common Name

English

EPAS1

Common Name

English

PAS DOMAIN-CONTAINING PROTEIN 2

Common Name

English

BHLHE73

Common Name

English

CLASS E BASIC HELIX- LOOP-HELIX PROTEIN 73

Common Name

English

Code System Code Type Description

PHAROS

Q99814

Created by admin on Tue Apr 01 20:13:38 GMT 2025 , Edited by admin on Tue Apr 01 20:13:38 GMT 2025

PRIMARY

UNIPROT

Q99814

Created by admin on Tue Apr 01 20:13:38 GMT 2025 , Edited by admin on Tue Apr 01 20:13:38 GMT 2025

PRIMARY

FDA UNII

1B37H0967P

Created by admin on Tue Apr 01 20:13:38 GMT 2025 , Edited by admin on Tue Apr 01 20:13:38 GMT 2025

PRIMARY

Related Record Type Details


					7K28NB895L

BELZUTIFAN

INHIBITOR -> TARGET

Comments:

Cellular luciferase assay. Compared to PT2385, found to be 2- to 3-fold more potent.

Qualification:

EC50

Amount:


					6O16716DXP

PT-2385

INHIBITOR -> TARGET

Amount:


					DP73UWL6LE

Casdatifan

INHIBITOR -> TARGET

Interaction Type:

PRECLINICAL

Amount:


					5BZT6LTA46

5-[[(4S,5S,6R)-3,3,5,6-Tetrafluoro-4-hydroxy-2,2-dioxo-2lambda6-thiatricyclo[5.3.1.04,11]undeca-1(11),7,9-trien-8-yl]oxy]pyridine-3-carbonitrile

INHIBITOR -> TARGET

Amount:

Structural Modifications

Modification Type	Location Site	Residue Modified	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_840]	T	THREONINE PHOSPHATE	3L4WX7B1EI
AMINO ACID SUBSTITUTION	[1_847]	N	3-HYDROXYASPARAGINE, (3S)-	9J17BCS69U
AMINO ACID SUBSTITUTION	[1_405] [1_531]	P	HYDROXYPROLINE	RMB44WO89X

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL