A?pE is of interest as it has been shown to be one of the dominant forms of A? present in the hippocampi and cortices of patients with Alzheimer's disease. However, arguably of most importance is that A?pE is specifically only found within cerebral A? plaques.2 In-vitro analysis has revealed that A?pE3 shows an increased rate of aggregation up to 250 times that of full-length A?, irrespective of its C terminus.
A?pE is of interest as it has been shown to be one of the dominant forms of A? present in the hippocampi and cortices of patients with Alzheimer's disease. However, arguably of most importance is that A?pE is specifically only found within cerebral A? plaques.2 In-vitro analysis has revealed that A?pE3 shows an increased rate of aggregation up to 250 times that of full-length A?, irrespective of its C terminus.
