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Details

Stereochemistry ACHIRAL
Molecular Formula C12H23N
Molecular Weight 181.3177
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DICYCLOHEXYLAMINE

SMILES

C1CCC(CC1)NC2CCCCC2

InChI

InChIKey=XBPCUCUWBYBCDP-UHFFFAOYSA-N
InChI=1S/C12H23N/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h11-13H,1-10H2

HIDE SMILES / InChI

Molecular Formula C12H23N
Molecular Weight 181.3177
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Dicyclohexylamine is an inhibitor of bacterial and mammalian spermidine synthase, an inhibitor of aminopropyltransferases, promotes ornithine decarboxylase activity possibly by the inhibition of spermidine biosynthesis. A possible antifungal agent in combination with 2,4,5-triochlorophenol.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
97.0 µM [IC50]
0.2 µM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
100 uM-200 uM of Dicyclohexylamine decreased P. falciparum strain NF54 parasitemias to 0% within 72 hours
Substance Class Chemical
Record UNII
1A93RJW924
Record Status Validated (UNII)
Record Version