Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H30NO.I |
Molecular Weight | 451.3842 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[I-].CC[N+](CC)(CC)CCOC1=CC=C(\C=C\C2=CC=CC=C2)C=C1
InChI
InChIKey=RDTKUZXIHMTSJO-UEIGIMKUSA-M
InChI=1S/C22H30NO.HI/c1-4-23(5-2,6-3)18-19-24-22-16-14-21(15-17-22)13-12-20-10-8-7-9-11-20;/h7-17H,4-6,18-19H2,1-3H3;1H/q+1;/p-1/b13-12+;
Molecular Formula | HI |
Molecular Weight | 127.9124 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C22H30NO |
Molecular Weight | 324.4797 |
Charge | 1 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Optical Activity | NONE |
Stilonium Iodide (also known as MG 624) is a trimethylethanaminium derivative with ganglionic-blocking action. Stilonium Iodide acts as α7-nicotinic receptor antagonist and Stilonium Iodide inhibits transmission between preganglionic and postganglionic neurons in the Autonomic Nervous System. Stilonium Iodide inhibits nicotine-induced proliferation and angiogenesis in human microvascular endothelial cells of the lung. Stilonium Iodide displayed anti-angiogenic activity in Matrigel, rat aortic ring and rat retinal explant assays. Furthermore, MG624 suppressed angiogenesis of NCI-H69 human SCLC tumors in vivo in both the chicken chorioallantoic membrane (CAM) and nude mice model.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2492 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16033252 |
110.0 nM [IC50] | ||
Target ID: CHEMBL1907589 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16033252 |
3.2 µM [IC50] |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 17:11:21 GMT 2023
by
admin
on
Sat Dec 16 17:11:21 GMT 2023
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Record UNII |
19B3530KQ6
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Record Status |
Validated (UNII)
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Record Version |
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Common Name | English |
Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29698
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19B3530KQ6
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SUB10652MIG
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C73168
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DTXSID2045781
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CHEMBL191491
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100000083482
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77257-42-2
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6433339
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3704
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Related Record | Type | Details | ||
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PARENT -> SALT/SOLVATE |