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Details

Stereochemistry ABSOLUTE
Molecular Formula C48H74N12O22
Molecular Weight 1171.1703
Optical Activity UNSPECIFIED
Defined Stereocenters 10 / 10
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLASPIMOD

SMILES

NCCCC[C@H](NC(=O)[C@H](CCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCC(=O)N2)C(O)=O

InChI

InChIKey=CNYIEQNFOBBXCP-CJMGQXRASA-N
InChI=1S/C48H74N12O22/c49-19-5-3-9-29(47(79)80)57-39(71)23(53-45(77)31(21-37(67)68)59-43(75)27(13-17-35(63)64)55-41(73)25-11-15-33(61)51-25)7-1-2-8-24(40(72)58-30(48(81)82)10-4-6-20-50)54-46(78)32(22-38(69)70)60-44(76)28(14-18-36(65)66)56-42(74)26-12-16-34(62)52-26/h23-32H,1-22,49-50H2,(H,51,61)(H,52,62)(H,53,77)(H,54,78)(H,55,73)(H,56,74)(H,57,71)(H,58,72)(H,59,75)(H,60,76)(H,63,64)(H,65,66)(H,67,68)(H,69,70)(H,79,80)(H,81,82)/t23-,24-,25-,26-,27-,28-,29-,30-,31-,32-/m0/s1

HIDE SMILES / InChI

Molecular Formula C48H74N12O22
Molecular Weight 1171.1703
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 10 / 10
E/Z Centers 0
Optical Activity UNSPECIFIED

Glaspimod (SK&F 107647) is a synthetic hematoregulatory peptide that shares biological and/or modulatory activities with natural hematopoietic cytokines. The peptide has been tested in vitro and in vivo for hematopoietic effects (involvement in production of cellular blood components). In vitro, glaspimod has no direct colony-stimulating activity (CSA), In vivo, injection of the compound results in an increase in serum CSA (maximal at 6 hours after injection). With repeated administration, significant increases in absolute numbers of granulocyte-macrophage (CFU-GM), erythroid (BFU-E), and multipotential (CFU-GEMM) progenitor cells can be measured. Pharmacokinetic effects of glasmipod have been studied in patients with adenocarcinoma and were not amenable to standard therapy.

Approval Year

Substance Class Chemical
Created
by admin
on Mon Mar 31 18:00:34 GMT 2025
Edited
by admin
on Mon Mar 31 18:00:34 GMT 2025
Record UNII
198E564V9F
Record Status FAILED
Record Version
  • Download
Name Type Language
GLASPIMOD
INN  
INN  
Official Name English
glaspimod [INN]
Preferred Name English
L-LYSINE, N2,N7-BIS(5-OXO-L-PROLYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-ASPARTYL)-(2S,7S)-2,7-DIAMINOOCTANEDIOYLBIS-
Systematic Name English
SK&F 107647
Code English
SK&F-107647
Code English
SB-107647
Code English
SKF-107647
Code English
Code System Code Type Description
PUBCHEM
9898394
Created by admin on Mon Mar 31 18:00:34 GMT 2025 , Edited by admin on Mon Mar 31 18:00:34 GMT 2025
PRIMARY
SMS_ID
100000080400
Created by admin on Mon Mar 31 18:00:34 GMT 2025 , Edited by admin on Mon Mar 31 18:00:34 GMT 2025
PRIMARY
NCI_THESAURUS
C166482
Created by admin on Mon Mar 31 18:00:34 GMT 2025 , Edited by admin on Mon Mar 31 18:00:34 GMT 2025
PRIMARY
FDA UNII
198E564V9F
Created by admin on Mon Mar 31 18:00:34 GMT 2025 , Edited by admin on Mon Mar 31 18:00:34 GMT 2025
PRIMARY
ChEMBL
CHEMBL2105859
Created by admin on Mon Mar 31 18:00:34 GMT 2025 , Edited by admin on Mon Mar 31 18:00:34 GMT 2025
PRIMARY
EVMPD
SUB07910MIG
Created by admin on Mon Mar 31 18:00:34 GMT 2025 , Edited by admin on Mon Mar 31 18:00:34 GMT 2025
PRIMARY
INN
7466
Created by admin on Mon Mar 31 18:00:34 GMT 2025 , Edited by admin on Mon Mar 31 18:00:34 GMT 2025
PRIMARY
CAS
134143-28-5
Created by admin on Mon Mar 31 18:00:34 GMT 2025 , Edited by admin on Mon Mar 31 18:00:34 GMT 2025
PRIMARY