Cicloxilic acid is a choleretic agent. Cicloxilic acid feeding lowered bile saturation (though bile tended to remain more saturated than normal) without affecting total bile acid pool size. The efficacy of cicloxilic acid in lowering biliary cholesterol saturation was not due to changes of dietary cholesterol absorption or of hepatic cholesterol synthesis. Hepatic cholesterogenesis and dietary cholesterol absorption are unaffected by cicloxilic acid feeding. Since cicloxilic acid is safe, cheap and lowers bile cholesterol saturation, this compound might have a place in gallstone disease either in association with the litholytic bile acids or in prevention of stone formation in high-risk populations (diabetics, obese, hyperlipidemic, etc.).