TRIMYRISTIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C45H86O6
Molecular Weight	723.1607
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC

InChI

InChIKey=DUXYWXYOBMKGIN-UHFFFAOYSA-N

InChI=1S/C45H86O6/c1-4-7-10-13-16-19-22-25-28-31-34-37-43(46)49-40-42(51-45(48)39-36-33-30-27-24-21-18-15-12-9-6-3)41-50-44(47)38-35-32-29-26-23-20-17-14-11-8-5-2/h42H,4-41H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C45H86O6
Molecular Weight	723.1607
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.hmdb.ca/metabolites/HMDB0042061 | https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=6aa6ad3f-2c52-4031-9e6c-7526c42de71d&type=display

TRIMYRISTIN is an inactive component of RODAN AND FIELDS ENHANCEMENTS used to prevent sunburns. TRIMYRISTIN is a constituent of nutmegs.

Approval Year

PubMed

Title	Date	PubMed
Curcuminoids-loaded lipid nanoparticles: novel approach towards malaria treatment.	2010-11-01	20688493
Short chain saturated fatty acids decrease circulating cholesterol and increase tissue PUFA content in the rat.	2010-11	20924709
Myristate is selectively incorporated into surfactant and decreases dipalmitoylphosphatidylcholine without functional impairment.	2010-11	20811010
Composition and metabolism of carbohydrates and lipids in Sparus aurata semen and its relation to viability expressed as sperm motility when activated.	2010-09	20441800
Nondestructive rheological measurement of aqueous dispersions of solid lipid nanoparticles: effects of lipid types and concentrations on dispersion consistency.	2010-09	20184417
Possible fungistatic implications of betulin presence in betulaceae plants and their hymenochaetaceae parasitic fungi.	2010-05-18	20469638
Regulation of hepatic gene expression by saturated fatty acids.	2010-03-16	20227267
Enzyme Inhibition by Molluscicidal Components of Myristica fragrans Houtt. in the Nervous Tissue of Snail Lymnaea acuminata.	2010	21048864
Fatty acid selectivity of lipases during acidolysis reaction between oleic acid and monoacid triacylglycerols.	2009-11-11	19835376
Myristic Acid, A Side Chain of Phorbol Myristate Acetate (PMA), Can Activate Human Polymorphonuclear Leukocytes to Produce Oxygen Radicals More Potently than PMA.	2009-11	19902021
Thermostable lipases from the extreme thermophilic anaerobic bacteria Thermoanaerobacter thermohydrosulfuricus SOL1 and Caldanaerobacter subterraneus subsp. tengcongensis.	2009-09	19579003
Solid lipid nanoparticles: a modern formulation approach in drug delivery system.	2009-07	20502539
Alkane inducible proteins in Geobacillus thermoleovorans B23.	2009-03-25	19320977
Lipid nanoparticles for transdermal delivery of flurbiprofen: formulation, in vitro, ex vivo and in vivo studies.	2009-02-26	19243632
Improving oral absorption of Salmon calcitonin by trimyristin lipid nanoparticles.	2009-02	20055109
Immediate release pellets with lipid binders obtained by solvent-free cold extrusion.	2009-01	18805483
Development of SLN and NLC enriched hydrogels for transdermal delivery of nitrendipine: in vitro and in vivo characteristics.	2009-01	18665979
Dynamics of different-sized solid-state nanocrystals as tracers for a drug-delivery system in the interstitium of a human tumor xenograft.	2009	19575785
Poly(vinyl alcohol) as emulsifier stabilizes solid triglyceride drug carrier nanoparticles in the alpha-modification.	2008-12-04	19049318
Solid lipid extrudates as sustained-release matrices: the effect of surface structure on drug release properties.	2008-11-15	18765281
Isolation of lipase producing Bacillus sp. from olive mill wastewater and improving its enzyme activity.	2007-11-19	17532131
Lipids of human meibum: mass-spectrometric analysis and structural elucidation.	2007-10	17626978
Tracking single lipase molecules on a trimyristin substrate surface using quantum dots.	2007-07-31	17616159
Effects of stereospecific positioning of fatty acids in triacylglycerol structures in native and randomized fats: a review of their nutritional implications.	2007-07-12	17625019
Confocal microscopy for the elucidation of mass transport mechanisms involved in protein release from lipid-based matrices.	2007-07	17457662
Cloning, expression, and characterization of a cold-adapted lipase gene from an antarctic deep-sea psychrotrophic bacterium, Psychrobacter sp 7195.	2007-04	18051271
Preparation, characterization and in vitro cytotoxicity of paclitaxel-loaded sterically stabilized solid lipid nanoparticles.	2007-04	17257668
Mobility of Thermomyces lanuginosus lipase on a trimyristin substrate surface.	2007-02-27	17261037
Pharmacokinetics, tissue distribution and bioavailability of nitrendipine solid lipid nanoparticles after intravenous and intraduodenal administration.	2006-11	17090399
Drug release from lipid-based implants: elucidation of the underlying mass transport mechanisms.	2006-05-18	16503388
Antibacterial principles from Myristica fragrans seeds.	2006	17004905
Saturated phospholipids promote crystallization but slow down polymorphic transitions in triglyceride nanoparticles.	2005-10-03	16023752
Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration.	2005-10-03	16014318
Isostatic ultra-high-pressure effects on supercooled melts in colloidal triglyceride dispersions.	2005-10	16180129
Dialkylphosphatidylcholine and egg yolk lecithin for emulsification of various triglycerides.	2005-04-10	15748826
Raman spectroscopy investigation of various saturated monoacid triglycerides.	2005-04	15784230
Investigation on the flow behavior of dispersions of solid triglyceride nanoparticles.	2004-10-13	15454303
Cytotoxicity studies of Dynasan 114 solid lipid nanoparticles (SLN) on RAW 264.7 macrophages-impact of phagocytosis on viability and cytokine production.	2004-07	15233867
Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles.	2004-03-24	15023472
A supercritical fluid-based coating technology. 3: preparation and characterization of bovine serum albumin particles coated with lipids.	2003-01-10	12519706
A supercritical fluid-based coating technology. 2: solubility considerations.	2003-01-10	12519705
A supercritical fluid-based coating technology 1: process considerations.	2003-01-10	12519704
Monolithic glyceryl trimyristate matrices for parenteral drug release applications.	2003-01	12551714
Monolithic triglyceride matrices: a controlled-release system for proteins.	2003	12665199
Microencapsulation of protein particles within lipids using a novel supercritical fluid process.	2002-08-21	12176227
Rapid thermogravimetric measurements of boiling points and vapor pressure of saturated medium- and long-chain triglycerides.	2002-08	12137273
Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)--effect of surfactants, storage time and crystallinity.	2002-04-26	11955810
Anxiogenic activity of Myristica fragrans seeds.	2002-01-29	11812528
Process development for production of medium chain triglycerides using immobilized lipase in a solvent-free system.	2002	12018320
Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate.	2001	11800053

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:36:56 GMT 2025` Edited by `admin` on `Mon Mar 31 17:36:56 GMT 2025`
Record UNII	18L31PSR28
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TRIMYRISTIN

Official Name

English

NSC-4062

Preferred Name

English

MYRISTIN

Common Name

English

TETRADECANOIC ACID, 1,1',1''-(1,2,3-PROPANETRIYL) ESTER

Common Name

English

DYNASAN 114

Common Name

English

GLYCERYL TRIMYRISTATE

Systematic Name

English

TETRADECANOIC ACID, 1,2,3-PROPANETRIYL ESTER

Common Name

English

GLYCEROL TRIMYRISTATE

Systematic Name

English

TRIMYRISTIN [MI]

Common Name

English

1,2,3-PROPANETRIOL TRITETRADECANOATE

Systematic Name

English

TRIMYRISTIN [II]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C492