BUTYROPHENONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H12O
Molecular Weight	148.2017
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC(=O)C1=CC=CC=C1

InChI

InChIKey=FFSAXUULYPJSKH-UHFFFAOYSA-N

InChI=1S/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3

HIDE SMILES / InChI

Molecular Formula	C10H12O
Molecular Weight	148.2017
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Droperidol for acute psychosis.	2001	11406047
Use of olanzapine in non-psychotic psychiatric disorders.	2001 Apr	11336615
Effect of hyperprolactinemia induced by pituitary grafts or castration on porphyrin content of the mouse Harderian gland.	2001 Aug	11552298
Suspected induction of a pyoderma gangrenosum-like eruption due to sulpiride treatment.	2001 Mar	11270303
Benperidol for schizophrenia.	2002	11869652
Antipsychotic and antidepressant drug use in the elderly and the risk of venous thromboembolism.	2002 Aug	12195690
Functional cooperation between neurosteroids and D2 dopamine antagonists on KCl-evoked [3H]noradrenaline release: modulation by calcium channel blockers.	2002 Dec	12472876
Differential inhibition of T-type calcium channels by neuroleptics.	2002 Jan 15	11784784
Comparative efficacy of centbutindole & risperidone in schizophrenia.	2002 Oct	21206602
A hybrid microdevice for electrophoresis and electrochromatography using UV detection.	2002 Oct	12412115
Platelet serotonin transporter in schizophrenic patients with and without neuroleptic treatment.	2002 Oct	12106771
Droperidol, QT prolongation, and sudden death: what is the evidence?	2003 Apr	12658255
Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine.	2003 Jan	12649767
The evolving management of migraine.	2003 Jun	12858071
Rhodium-catalyzed addition/ring-opening reaction of arylboronic acids with cyclobutanones.	2004 Apr 15	15070311
[Butyrophenone derivatives].	2004 Dec	15658342
Antipsychotics and the risk of sudden cardiac death.	2004 Jun 28	15226162
Multiresidue method for the detection of tranquillisers, xylazine, and a beta-blocker in animal production by liquid chromatography-tandem mass spectrometry.	2004 Oct 29	15553165
A review of drugs and techniques used for sedation and anaesthesia in captive rhinoceros species.	2004 Sep	15478725
Benperidol for schizophrenia.	2005 Apr 18	15846648
Synthesis, neutron structure, and reactivity of the bis(dihydrogen) complex RuH2(eta(2)-H2)2(PCyp3)2 stabilized by two tricyclopentylphosphines.	2005 Dec 21	16351074
Factors related to prescription dosage in Japanese psychiatric hospitals.	2005 Feb	15679543
Safety of haloperidol and penfluridol in pregnancy: a multicenter, prospective, controlled study.	2005 Mar	15766297
Successful treatment of six patients with neuroleptic malignant syndrome associated with myoglobulinemic acute renal failure.	2006	16526319
Systematic review of antipsychotics for the treatment of hospital-associated delirium in medically or surgically ill patients.	2006 Nov	17047137
Forty years of antipsychotic Drug research--from haloperidol to paliperidone--with Dr. Paul Janssen.	2007	18074755
Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis.	2007 Apr	16823387
Methyl chloroacetate as an extraction solvent for coupling liquid-liquid semimicroextraction with micellar electrokinetic chromatography through on-capillary decomposition for the separation of neutral compounds with concentration enhancement.	2007 Apr 13	17331520
Fifty years chlorpromazine: a historical perspective.	2007 Aug	19300578
Pesticides in surface drinking-water supplies of the northern Great Plains.	2007 Aug	17687445
Rational design, synthesis and evaluation of (6aR( ),11bS( ))-1-(4-fluorophenyl)-4-{7-[4-(4-fluorophenyl)-4-oxobutyl]1,2,3,4,6,6a,7,11b,12,12a(RS)-decahydropyrazino[2',1':6,1]pyrido[3,4-b]indol-2-yl}-butan-1-one as a potential neuroleptic agent.	2007 Dec 1	17869521
Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones.	2007 Feb	17373555
Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity.	2007 Jun	17092607
Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting.	2007 May	17470885
Effects of haloperidol and its pyridinium metabolite on plasma membrane permeability and fluidity in the rat brain.	2007 May 9	17363126
A prototypical Sigma-1 receptor antagonist protects against brain ischemia.	2007 Nov 21	17919467
Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics.	2007 Sep 1	17588750
Trends in hospital admissions for adverse drug reactions in England: analysis of national hospital episode statistics 1998-2005.	2007 Sep 25	17894876
Chemotherapy-and cancer-related nausea and vomiting.	2008 Jan	18231647
Antagonist-radioligand binding to D2L-receptors in intact cells.	2008 Jun 1	18436192
Determination of gaseous organic compounds in Hyogo Prefecture, Japan.	2008 Nov	19062708
Automated on-line in-tube solid-phase microextraction coupled with HPLC/MS/MS for the determination of butyrophenone derivatives in human plasma.	2009 Jun	19387622
4-(4-Chloro-phen-yl)-1-[3-(4-fluoro-benzo-yl)prop-yl]-4-hydroxy-piperidin-1-ium 2,4,6-trinitro-phenolate (haloperidol picrate).	2009 Sep 9	21577866
Antagonist-D2S-dopamine receptor interactions in intact recombinant Chinese hamster ovary cells [corrected].	2010 Jun	20015228
Effect of alkyl substituents on photorelease from butyrophenone derivatives.	2010 Mar 5	20113004

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:57:18 GMT 2023` Edited by `admin` on `Fri Dec 15 18:57:18 GMT 2023`
Record UNII	186I11WB5B
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BUTYROPHENONE

Systematic Name

English

NSC-8463

Code

English

1-PHENYLBUTAN-1-ONE

Systematic Name

English

Code System Code Type Description

NSC

8463