Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H12O |
| Molecular Weight | 148.2017 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC(=O)C1=CC=CC=C1
InChI
InChIKey=FFSAXUULYPJSKH-UHFFFAOYSA-N
InChI=1S/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3
| Molecular Formula | C10H12O |
| Molecular Weight | 148.2017 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Droperidol for treatment of nausea and vomiting in palliative care patients. | 2010-10-06 |
|
| The subtype-specific effects of droperidol on action potential duration in cellular and computational models of long QT syndrome. | 2010-09 |
|
| Antagonist-D2S-dopamine receptor interactions in intact recombinant Chinese hamster ovary cells [corrected]. | 2010-06 |
|
| Effect of alkyl substituents on photorelease from butyrophenone derivatives. | 2010-03-05 |
|
| MDMA-evoked changes in the binding of dopamine D(2) receptor ligands in striatum of rats with unilateral serotonin depletion. | 2010-01 |
|
| Acute gastroenteritis: from guidelines to real life. | 2010 |
|
| Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. | 2009-11-30 |
|
| 4-(4-Chloro-phen-yl)-1-[3-(4-fluoro-benzo-yl)prop-yl]-4-hydroxy-piperidin-1-ium 2,4,6-trinitro-phenolate (haloperidol picrate). | 2009-09-09 |
|
| [Pharmaco-therapeutic evaluation of medical treatments of adult autistics and multi-handicapped patients in a public mental health unit]. | 2009-09 |
|
| Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics. | 2009-07 |
|
| Automated on-line in-tube solid-phase microextraction coupled with HPLC/MS/MS for the determination of butyrophenone derivatives in human plasma. | 2009-06 |
|
| The consolidation of neuroleptic therapy: Janssen, the discovery of haloperidol and its introduction into clinical practice. | 2009-04-29 |
|
| Determination of gaseous organic compounds in Hyogo Prefecture, Japan. | 2008-11 |
|
| Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one. | 2008-08-01 |
|
| Antagonist-radioligand binding to D2L-receptors in intact cells. | 2008-06-01 |
|
| Chemotherapy-and cancer-related nausea and vomiting. | 2008-01 |
|
| Rational design, synthesis and evaluation of (6aR( *),11bS( *))-1-(4-fluorophenyl)-4-{7-[4-(4-fluorophenyl)-4-oxobutyl]1,2,3,4,6,6a,7,11b,12,12a(RS)-decahydropyrazino[2',1':6,1]pyrido[3,4-b]indol-2-yl}-butan-1-one as a potential neuroleptic agent. | 2007-12-01 |
|
| A prototypical Sigma-1 receptor antagonist protects against brain ischemia. | 2007-11-21 |
|
| Trends in hospital admissions for adverse drug reactions in England: analysis of national hospital episode statistics 1998-2005. | 2007-09-25 |
|
| Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics. | 2007-09-01 |
|
| Fifty years chlorpromazine: a historical perspective. | 2007-08 |
|
| Pesticides in surface drinking-water supplies of the northern Great Plains. | 2007-08 |
|
| Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity. | 2007-06 |
|
| Effects of haloperidol and its pyridinium metabolite on plasma membrane permeability and fluidity in the rat brain. | 2007-05-09 |
|
| Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. | 2007-05 |
|
| Methyl chloroacetate as an extraction solvent for coupling liquid-liquid semimicroextraction with micellar electrokinetic chromatography through on-capillary decomposition for the separation of neutral compounds with concentration enhancement. | 2007-04-13 |
|
| Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis. | 2007-04 |
|
| Inhibition of carbonyl reductase activity in pig heart by alkyl phenyl ketones. | 2007-02 |
|
| Forty years of antipsychotic Drug research--from haloperidol to paliperidone--with Dr. Paul Janssen. | 2007 |
|
| Systematic review of antipsychotics for the treatment of hospital-associated delirium in medically or surgically ill patients. | 2006-11 |
|
| QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine. | 2006-08 |
|
| The haloperidol story. | 2006-01-26 |
|
| Successful treatment of six patients with neuroleptic malignant syndrome associated with myoglobulinemic acute renal failure. | 2006 |
|
| Synthesis, neutron structure, and reactivity of the bis(dihydrogen) complex RuH2(eta(2)-H2)2(PCyp3)2 stabilized by two tricyclopentylphosphines. | 2005-12-21 |
|
| Haloperidol: an alternative butyrophenone for nausea and vomiting prophylaxis in anesthesia. | 2005-08 |
|
| Benperidol for schizophrenia. | 2005-04-18 |
|
| Safety of haloperidol and penfluridol in pregnancy: a multicenter, prospective, controlled study. | 2005-03 |
|
| Factors related to prescription dosage in Japanese psychiatric hospitals. | 2005-02 |
|
| Haloperidol: towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors. | 2004-12-06 |
|
| [Butyrophenone derivatives]. | 2004-12 |
|
| Multiresidue method for the detection of tranquillisers, xylazine, and a beta-blocker in animal production by liquid chromatography-tandem mass spectrometry. | 2004-10-29 |
|
| Droperidol for acute psychosis. | 2004-10-18 |
|
| A review of drugs and techniques used for sedation and anaesthesia in captive rhinoceros species. | 2004-09 |
|
| Antipsychotics and the risk of sudden cardiac death. | 2004-06-28 |
|
| Rhodium-catalyzed addition/ring-opening reaction of arylboronic acids with cyclobutanones. | 2004-04-15 |
|
| [Injection anesthesia administered in the mid-anesthesia period after ether induction in laboratory rats]. | 2003-12 |
|
| The evolving management of migraine. | 2003-06 |
|
| Droperidol, QT prolongation, and sudden death: what is the evidence? | 2003-04 |
|
| Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine. | 2003-01 |
|
| Comparative efficacy of centbutindole & risperidone in schizophrenia. | 2002-10 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:27:50 GMT 2025
by
admin
on
Mon Mar 31 19:27:50 GMT 2025
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| Record UNII |
186I11WB5B
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| Record Status |
Validated (UNII)
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| Record Version |
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8463
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186I11WB5B
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DTXSID3047059
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207-799-7
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10315
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C323
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495-40-9
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Butyrophenone
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
