TAZOLOL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C9H16N2O2S.ClH
Molecular Weight	252.761
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)NCC(O)COC1=NC=CS1

InChI

InChIKey=DHJWBCUZURVUCT-UHFFFAOYSA-N

InChI=1S/C9H16N2O2S.ClH/c1-7(2)11-5-8(12)6-13-9-10-3-4-14-9;/h3-4,7-8,11-12H,5-6H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C9H16N2O2S
Molecular Weight	216.301
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10864 | https://www.ncbi.nlm.nih.gov/pubmed/235834

Tazolol is a selective myocardial beta-blocking agent. Experiments on dogs have shown that this compound could be useful in patients with heart failure due to coronary artery disease. However, information about the current use of tazolol is not available.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor beta 87 Target ID: CHEMBL2094118 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10864 \| https://www.ncbi.nlm.nih.gov/pubmed/2858837 \| https://www.ncbi.nlm.nih.gov/pubmed/2982014	Agonist 2678

PubMed

Title	Date	PubMed
Selective adrenergic stimulant actions of 1-isopropylamino-3-(2-thiazoloxy)-2-propanol (ITP) in anesthetized cats.	1974 Jan 1	4149302
Beta2-adrenergic stimulation of thyroid hormone secretion.	1975 Aug	239845
The cardiovascular pharmacology and hemodynamic activity of tazolol, a selective myocardial beta-stimulant.	1976 Aug	10864
Acute metabolic effects of adrenergic agents in swine.	1987 Jan	2880510

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:25:37 GMT 2023` Edited by `admin` on `Fri Dec 15 15:25:37 GMT 2023`
Record UNII	17VCV89R3L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TAZOLOL HYDROCHLORIDE

Official Name

English

TAZOLOL HYDROCHLORIDE [USAN]

Common Name

English

2-PROPANOL, 1-((1-METHYLETHYL)AMINO)-3-(2-THIAZOLYLOXY)-, MONOHYDROCHLORIDE, (±)-

Common Name

English

RS-6245

Code

English

TAZOLOL HCL

Common Name

English

(±)-1-(ISOPROPYLAMINO)-3-(2-THIAZOLYLOXY)-2-PROPANOL MONOHYDROCHLORIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C48149