BROMACRYLIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H11BrN2O2
Molecular Weight	235.078
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

BrCCC(=O)NCNC(=O)C=C

InChI

InChIKey=CDOUZKKFHVEKRI-UHFFFAOYSA-N

InChI=1S/C7H11BrN2O2/c1-2-6(11)9-5-10-7(12)3-4-8/h2H,1,3-5H2,(H,9,11)(H,10,12)

HIDE SMILES / InChI

Molecular Formula	C7H11BrN2O2
Molecular Weight	235.078
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13777315 | Cancer Chemotherapy Repts., Suppl. Volume 2 Page 1-401,403-1015,1017-528 Journal 1965 |

Bromacrylide is an acrylamide-based alkylating agent with antineoplastic activity. Bromacrylide after oral or intraperitoneal administration decrease tumor growth in animal models. Unfortunately, Bromacrylide demonstrates severe toxicity, including severe bone marrow suppression and weight loss.

Originator

Approval Year

PubMed

Title	Date	PubMed
N, N'-Alkylene-bis(acrylamides), N-(acrylamidomethyl)-3-halopropionamides and related compounds: a new series of anti-tumour agents.	1961-08-05	13777315

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:52:19 GMT 2025` Edited by `admin` on `Wed Apr 02 08:52:19 GMT 2025`
Record UNII	173648DEO8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BROMACRYLIDE

Official Name

English

NSC-66248

Preferred Name

English

bromacrylide [INN]

Common Name

English

N-((3-BROMOPROPIONAMIDO)METHYL)ACRYLAMIDE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C274