Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C28H32O13 |
| Molecular Weight | 576.5459 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12COC(=O)[C@]1([H])[C@H](C3=CC(OC)=C(OC)C(OC)=C3)C4=CC5=C(OCO5)C(O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)=C4C2
InChI
InChIKey=PAIASCMUTMHGHU-WELBBKRVSA-N
InChI=1S/C28H32O13/c1-34-15-5-11(6-16(35-2)25(15)36-3)19-13-7-17-26(39-10-38-17)24(14(13)4-12-9-37-27(33)20(12)19)41-28-23(32)22(31)21(30)18(8-29)40-28/h5-7,12,18-23,28-32H,4,8-10H2,1-3H3/t12-,18+,19+,20-,21+,22-,23+,28-/m0/s1
| Molecular Formula | C28H32O13 |
| Molecular Weight | 576.5459 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 8 / 8 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Antiviral activity of lignans. | 1998 Nov |
|
| Antiproliferative xanthones of Terminalia calcicola from the Madagascar rain forest. | 2007 Apr |
|
| Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest. | 2015 Jul 24 |
|
| Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications. | 2016 Mar 25 |
Patents
Sample Use Guides
Human A2780 ovarian cancer cells were harvested and resuspended in growth medium (RPMI1640 supplemented with 10% fetal bovine serum and 2 mM L-glutamine). Cells were counted and distributed to a 96 well plate. Plates were incubated for 3 hours at 37 deg-C in a 5% CO2 atmosphere. β-peltatin-β-D-glucopyranoside (β-peltatin) was prepared in 50/50 H2O/DMSO add added to the wells in an appropriate series of concentrations. Plates were then incubated for 2 days. The percent inhibition of cell growth was determined by measuring the conversion of AlamarBlue by fluorescence. β-peltatin-β-D-glucopyranoside was found to have an IC50 of 4.9 microM with respect to the proliferation of human A278- ovarian cancer cells.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:00:23 GMT 2023
by
admin
on
Sat Dec 16 10:00:23 GMT 2023
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| Record UNII |
1673AQJ022
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| Record Status |
Validated (UNII)
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| Record Version |
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m8455
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PRIMARY | Merck Index |