Details
Stereochemistry | ABSOLUTE |
Molecular Formula | 2C22H30N6OS.5BrH.H2O |
Molecular Weight | 1275.731 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O.Br.Br.Br.Br.Br.[H][C@]1(CN[C@@]([H])(C1)C(=O)N2CCSC2)N3CCN(CC3)C4=CC(C)=NN4C5=CC=CC=C5.[H][C@]6(CN[C@@]([H])(C6)C(=O)N7CCSC7)N8CCN(CC8)C9=CC(C)=NN9C%10=CC=CC=C%10
InChI
InChIKey=NQPRXLXVOBOTGT-KSLCDFCZSA-N
InChI=1S/2C22H30N6OS.5BrH.H2O/c2*1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27;;;;;;/h2*2-6,13,19-20,23H,7-12,14-16H2,1H3;5*1H;1H2/t2*19-,20-;;;;;;/m00....../s1
Molecular Formula | BrH |
Molecular Weight | 80.912 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C22H30N6OS |
Molecular Weight | 426.578 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | H2O |
Molecular Weight | 18.0153 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/23671395Curator's Comment: description was created based on several sources, including https://www.pmda.go.jp/files/000153594.pdf
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23671395
Curator's Comment: description was created based on several sources, including https://www.pmda.go.jp/files/000153594.pdf
Teneligliptin is a DPP IV inhibitor which was developed by Mitsubishi Tanabe Pharma and now is used for the treatment of type 2 diabetes mellitus in Asia under the name Tenelia.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL284 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23671395 |
0.889 nM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | TENELIA Approved UseType 2 diabetes mellitus. Launch Date1.33548474E12 |
PubMed
Title | Date | PubMed |
---|---|---|
Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. | 2012 Oct 1 |
|
Teneligliptin: a DPP-4 inhibitor for the treatment of type 2 diabetes. | 2013 |
|
Efficacy and safety of teneligliptin in combination with pioglitazone in Japanese patients with type 2 diabetes mellitus. | 2013 Nov 27 |
|
Efficacy, safety and dose-response relationship of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus. | 2013 Sep |
|
Teneligliptin as an initial therapy for newly diagnosed, drug naive subjects with type 2 diabetes. | 2014 Aug |
|
Add-on treatment with teneligliptin ameliorates glucose fluctuations and improves glycemic control index in Japanese patients with type 2 diabetes on insulin therapy. | 2014 Dec |
|
Teneligliptin improves glycemic control with the reduction of postprandial insulin requirement in Japanese diabetic patients. | 2015 |
|
Teneligliptin, a Dipeptidyl Peptidase-4 Inhibitor, Improves Early-Phase Insulin Secretion in Drug-Naïve Patients with Type 2 Diabetes. | 2015 Sep |
|
Comparative Binding Analysis of Dipeptidyl Peptidase IV (DPP-4) with Antidiabetic Drugs - An Ab Initio Fragment Molecular Orbital Study. | 2016 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.pmda.go.jp/files/000153594.pdf
The usual adult dosage is 20 mg of teneligliptin administered orally once daily. If efficacy is insufficient, the dose may be increased up to 40 mg once daily while closely monitoring the clinical course.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27530507
Human umbilical vein endothelial cells were cultured under normal (5 mmol/L) or high glucose level (25 mmol/L) during 21 days, or at high glucose during 14 days followed by 7 days at normal glucose, to reproduce the high-metabolic memory state. At this time, different concentrations of teneligliptin (0.1, 1.0 and 3.0 umol/L) were added to cells. Teneligliptin was shown to protect human umbilical vein endothelial cells from oxidative stress.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:14:35 UTC 2023
by
admin
on
Fri Dec 15 19:14:35 UTC 2023
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Record UNII |
15S4OCS6SS
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Record Status |
Validated (UNII)
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Record Version |
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SUB121309
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15S4OCS6SS
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ACTIVE MOIETY |