LUTIKIZUMAB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 11:55:24 UTC 2023` Edited by `admin` on `Sat Dec 16 11:55:24 UTC 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IMMUNOMODULATOR
Sequence Origin	HUMANIZED
Sequence Type	COMPLETE
Record UNII	15FAZ725S0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LUTIKIZUMAB

Official Name

English

LUTIKIZUMAB [USAN]

Common Name

English

ABT-981

Code

English

Lutikizumab [WHO-DD]

Common Name

English

Immunoglobulin G1-kappa, anti-[Homo sapiens IL1A (interleukin 1 alpha) and Homo sapiens IL1B (interleukin 1 beta, IL-1B, 1L1F2)], humanized monoclonal antibody, tetravalent bispecific; gamma1 heavy chain (1-577) [humanized VH anti-IL1B (Homo sapiens IGHV

Common Name

English

lutikizumab [INN]

Common Name

English

A-1234138

Code

English

Immunoglobulin, anti-(interleukin 1β/interleukin 1α) (synthetic human A-1234138 heavy chain), disulfide with synthetic human A-1234138 light chain, dimer

Common Name

English

Code System Code Type Description

USAN

JK-209

Created by admin on Sat Dec 16 11:55:24 UTC 2023 , Edited by admin on Sat Dec 16 11:55:24 UTC 2023

PRIMARY

FDA UNII

15FAZ725S0

Created by admin on Sat Dec 16 11:55:24 UTC 2023 , Edited by admin on Sat Dec 16 11:55:24 UTC 2023

PRIMARY

INN

10347

Created by admin on Sat Dec 16 11:55:24 UTC 2023 , Edited by admin on Sat Dec 16 11:55:24 UTC 2023

PRIMARY

CAS

1791411-57-8

Created by admin on Sat Dec 16 11:55:24 UTC 2023 , Edited by admin on Sat Dec 16 11:55:24 UTC 2023

PRIMARY

NCI_THESAURUS

C166465

Created by admin on Sat Dec 16 11:55:24 UTC 2023 , Edited by admin on Sat Dec 16 11:55:24 UTC 2023

PRIMARY

From	To
1_22	1_96
1_147	1_221
1_274	1_330
1_391	1_451
1_497	1_555
2_22	2_96
2_147	2_221
2_274	2_330
2_391	2_451
2_497	2_555
3_23	3_88
3_136	3_201
3_247	3_307
4_23	4_88
4_136	4_201
4_247	4_307
1_350	3_327
2_350	4_327
1_356	2_356
1_359	2_359

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_427
N	2_427

Related Record Type Details


					8666ZWZ3E1

INTERLEUKIN-1.ALPHA. (RECOMBINANT, NON-GLYCOSYLATED)

TARGET -> INHIBITOR

Amount:


					X62226112J

INTERLEUKIN-1 .BETA. HUMAN

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					15FAZ725S0

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL