AMINOOXYACETIC ACID

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2H5NO3
Molecular Weight	91.066
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NOCC(O)=O

InChI

InChIKey=NQRKYASMKDDGHT-UHFFFAOYSA-N

InChI=1S/C2H5NO3/c3-6-1-2(4)5/h1,3H2,(H,4,5)

HIDE SMILES / InChI

Molecular Formula	C2H5NO3
Molecular Weight	91.066
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Effects of some GABAergic agents on quinine-induced seizures in mice.	1992 Jul 15	1322322
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.	1992 Jun 19	1511512
Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice.	1992 Mar	1639237
Renal cysteine conjugate C-S lyase mediated toxicity of halogenated alkenes in primary cultures of human and rat proximal tubular cells.	2003 Jul	12700887
The metabolic pathway of salicylic acid rather than of chlorogenic acid is involved in the stress-induced flowering of Pharbitis nil.	2003 May	12806773
Ethylene insensitivity modulates ozone-induced cell death in birch.	2003 May	12746524
Does ethylene mediate cluster root formation under iron deficiency?	2003 Nov	12967908
13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and gamma-glutamyl cycle activity in a clonal pancreatic beta-cell line.	2003 Nov	12955201
Modulation of endogenous production of H2S in rat tissues.	2003 Sep	14614520
Mechanisms of pyruvate inhibition of oxidant-induced apoptosis in human endothelial cells.	2003 Sep	12935767
Overproduced ethylene causes programmed cell death leading to temperature-sensitive lethality in hybrid seedlings from the cross Nicotiana suaveolens x N. tabacum.	2003 Sep	12728318
Distinct trans-plasma membrane redox pathways reduce cell-impermeable dyes in HeLa cells.	2004	15720822
Energy substrate requirements of rat retinal pigmented epithelial cells in culture: relative importance of glucose, amino acids, and monocarboxylates.	2004 Apr	15037596
Crystal structures of unbound and aminooxyacetate-bound Escherichia coli gamma-aminobutyrate aminotransferase.	2004 Aug 31	15323550
Isolation and characterization of cytosolic alanine aminotransferase isoforms from starved rat liver.	2004 Dec	15663181
Nitrogen-15 NMR studies of nitrogen metabolism in Picea glauca buds.	2004 Dec	15596100
Reactive oxygen and ethylene are involved in the regulation of regurgitant-induced responses in bean plants.	2004 Feb	15022833
Purification and properties of cytosolic alanine aminotransferase from the liver of two freshwater fish, Clarias batrachus and Labeo rohita.	2004 Feb	14990216
Retinal function loss after monocarboxylate transport inhibition.	2004 Feb	14744902
Enhanced survival effect of pyruvate correlates MAPK and NF-kappaB activation in hydrogen peroxide-treated human endothelial cells.	2004 Feb	14578369
A proteomic analysis identifies glutathione S-transferase isoforms whose abundance is differentially regulated by ethylene during the formation of early root epidermis in Arabidopsis seedlings.	2004 Feb 20	14984929
Inhibition of [(15)N]valine transamination during selective labeling of barstar in a T7 polymerase system.	2004 Jul	15310282
Androgen secretion by Rcho-1 cells is independent of extracellular glutamate concentration.	2004 Jul	15135238
Differential in vitro development of inflorescences in long and short day Lemna spp.: involvement of ethylene and polyamines.	2004 Jun	15266712
Kynurenic acid production in cultured bovine aortic endothelial cells. Homocysteine is a potent inhibitor.	2004 Mar	14770276
Cellular glutathione prevents cytolethality of monomethylarsonic acid.	2004 Mar 1	14998680
Aminooxyacetic acid inhibits antheridiogenesis and development of Anemia phyllitidis gametophytes.	2004 Oct	15480681
Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis.	2004 Oct 7	15471546
Opioid modulation of GABA release in the rat inferior colliculus.	2004 Sep 7	15353008
Automorphosis of etiolated pea seedlings in space is simulated by a three-dimensional clinostat and the application of inhibitors of auxin polar transport.	2005 Apr	15844285
Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia.	2005 Apr 20	15791207
Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in oligodendrocyte cell line (OLN-93).	2005 Aug	16258845
Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice.	2005 Aug	15741243
Transamination in the metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in rats.	2005 Dec	16174804
Enhancement of photorespiration in immobilized Chlamydomonas reinhardtii cells.	2005 Feb	15742148
Chronic exposure to beta-hydroxybutyrate inhibits glucose-induced insulin release from pancreatic islets by decreasing NADH contents.	2005 Feb	15479955
Gamma-aminobutyric acid and mefloquine-induced seizures in mice.	2005 Jul	16009480
Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in cultured cerebral cortical neurons.	2005 Jun 1	15880762
Differential expression of genes encoding 1-aminocyclopropane-1-carboxylate synthase in Arabidopsis during hypoxia.	2005 May	16028113
Effect of aminooxyacetic acid on extracellular level of D-serine in rat striatum: an in vivo microdialysis study.	2005 Nov 21	16289454
Cultures of rat astrocytes challenged with a steady supply of glutamate: new model to study flux distribution in the glutamate-glutamine cycle.	2005 Sep	15834952
High plasma cyst(e)ine level may indicate poor clinical outcome in patients with acute stroke: possible involvement of hydrogen sulfide.	2006 Feb	16462202
Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools.	2006 Feb 14	16368075
Oligosaccharide microarrays fabricated on aminooxyacetyl functionalized glass surface for characterization of carbohydrate-protein interaction.	2006 Feb 15	16099642
Enzymatic and mechanistic studies on the formation of N-phenylglycolohydroxamic acid from nitrosobenzene and pyruvate in spinach leaf homogenate.	2006 Jan 25	16417326
Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide.	2006 Jul 1	16781459
Nonezymatic formation of succinate in mitochondria under oxidative stress.	2006 Jul 1	16781453
Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells.	2006 Jul 25	16846239
Demonstration of extensive GABA synthesis in the small population of GAD positive neurons in cerebellar cultures by the use of pharmacological tools.	2006 May-Jun	16516347
Kynurenic acid leads, dopamine follows: a new case of volume transmission in the brain?	2007 Jan	16932989

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:48:07 GMT 2023` Edited by `admin` on `Fri Dec 15 15:48:07 GMT 2023`
Record UNII	14I68GI3OQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMINOOXYACETIC ACID

Systematic Name

English

AOAA

Common Name

English

ACETIC ACID, (AMINOOXY)-

Common Name

English

U-7524

Code

English

AMINOXYACETIC ACID

Common Name

English

CARBOXYMETHOXYAMINE

Systematic Name

English

(AMINOOXY)ACETIC ACID

Systematic Name

English

Code System Code Type Description

DRUG BANK

DB02079