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NEDOSIRAN
13U9R5J3WL
US Approved Rx (2023)
First approved in 2023
General
Record Details
Names
6
Identifiers
5
Subunits
2
Sugars
3
Linkages
2
Relationships
1
Modifications
3
NEDOSIRAN
13U9R5J3WL
US Approved Rx (2023)
First approved in 2023
General
Approval Year
2023
455
Record Details
Substance Class
Nucleic Acid
Nucleic Acid Type
RNAI
Nucleic Acid Subtype
Sequence Type
COMPLETE
Record UNII
13U9R5J3WL
Record Status
Validated (UNII)
Record Version
25
24
23
22
21
20
19
18
17
16
15
14
13
12
11
10
9
8
7
6
5
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1
Names
6
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entries
Name
Type
Language
Name
Type
Language
NEDOSIRAN
Official Name
English
nedosiran [INN]
Common Name
English
Nedosiran [WHO-DD]
Common Name
English
NEDOSIRAN [USAN]
Common Name
English
RNA, (AM-SP-UM-(2'-DEOXY-2'-FLUORO)G-UM-(2'-DEOXY-2'-FLUORO)U-GM-UM-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)U-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)U-UM-(2'-DEOXY-2'-FLUORO)A-UM-(2'-DEOXY-2'-FLUORO)C-UM-GM-AM-GM-CM-AM-GM-CM
Systematic Name
English
Showing 1 to 5 of 6 entries
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2
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Identifiers
5
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entries
Code System
Code
Type
Description
Code System
Code
Type
Description
CAS
2266591-83-5
PRIMARY
USAN
HI-158
PRIMARY
FDA UNII
13U9R5J3WL
PRIMARY
NCI_THESAURUS
C175828
PRIMARY
INN
11373
PRIMARY
Showing 1 to 5 of 5 entries
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Subunits
2
Subunit 0
>SUBUNIT_0
Subunit 1
>SUBUNIT_1
Sugars
3
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entries
Sugar
Site Range
Site Count
Sugar
Site Range
Site Count
2'-Fluoro-Ribose
1_2-1_5;1_7;1_9-1_10;1_14;1_16;1_18;2_3;2_5;2_8-2_11;2_13;2_15;2_17
19 / 58
2'-O-Methyl-Ribose
1_1;1_6;1_8;1_11-1_13;1_15;1_17;1_19-1_22;2_1-2_2;2_4;2_6-2_7;2_12;2_14;2_16;2_18-2_26;2_31-2_36
35 / 58
D-Ribose (RNA)
2_27-2_30
4 / 58
Showing 1 to 3 of 3 entries
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Linkages
2
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entries
Linkage
Site Range
Site Count
Linkage
Site Range
Site Count
Phosporothioate
1_1-1_3;1_20-1_21;2_1
6 / 56
Phosphate
1_4-1_19;2_2-2_35
50 / 56
Showing 1 to 2 of 2 entries
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Relationships
1
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entries
Related Record
Type
Details
Related Record
Type
Details
4IDZ3J79QQ
L-LACTATE DEHYDROGENASE A CHAIN
TARGET->INHIBITOR OF EXPRESSION
Showing 1 to 1 of 1 entries
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Modifications
3
Structural Modifications
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entries
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
NUCLEOSIDE_SUBSTITUTION
[2_28] [2_29] [2_30]
UNSPECIFIED SUBSTANCE
3a625511
(not in database)
NUCLEOSIDE_SUBSTITUTION
[2_27]
SITE_SPECIFIC
UNSPECIFIED SUBSTANCE
4b489b28
(not in database)
NUCLEOSIDE_SUBSTITUTION
[1_1]
5'-TERMINUS
UNSPECIFIED SUBSTANCE
55513d6d
(not in database)
Showing 1 to 3 of 3 entries
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