Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H6N4O2 |
| Molecular Weight | 166.1374 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C=NC2=C1NC(=O)NC2=O
InChI
InChIKey=DHNIKYWYTSMDDA-UHFFFAOYSA-N
InChI=1S/C6H6N4O2/c1-10-2-7-3-4(10)8-6(12)9-5(3)11/h2H,1H3,(H2,8,9,11,12)
| Molecular Formula | C6H6N4O2 |
| Molecular Weight | 166.1374 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Theobromine inhibits sensory nerve activation and cough. | 2005-02 |
|
| Lisofylline: a potential lead for the treatment of diabetes. | 2005-01-01 |
|
| Molecular recognition and crystal energy landscapes: an X-ray and computational study of caffeine and other methylxanthines. | 2004-12-17 |
|
| Determination of methylxanthines in urine by liquid chromatography with diode array UV detection. | 2004-11-15 |
|
| Methylxanthines are the psycho-pharmacologically active constituents of chocolate. | 2004-11 |
|
| Urinary methylxanthine and autistic disorder: absence of previously reported correlation. | 2004-10 |
|
| Separation, pre-concentration, and HPLC analysis of methylxanthines in urine samples. | 2004-10 |
|
| Theophylline increases the uptake of radioiodine by mouse thyroid. | 2004-10 |
|
| Theophylline, a methylxanthine derivative, suppresses absence epileptic seizures in WAG/Rij rats. | 2004-10 |
|
| Influence of pentoxifylline on perforin expression in human PBMC. | 2004-10 |
|
| Chlorambucil plus theophylline vs chlorambucil alone as a front line therapy for B-cell chronic lymphatic leukemia. | 2004-10 |
|
| Phase II study of theophylline in chronic lymphocytic leukemia: a study of the Eastern Cooperative Oncology Group (E4998). | 2004-10 |
|
| Respiratory development in preterm infants. | 2004-10 |
|
| Phosphodiesterase inhibitors as anti-cancer drugs. | 2004-09-15 |
|
| Pharmacologic therapy for acute exacerbations of chronic obstructive pulmonary disease: a review. | 2004-09 |
|
| Chronic obstructive pulmonary disease: the clinical management of an acute exacerbation. | 2004-09 |
|
| Protein-polyamine conjugation by transglutaminase in cancer cell differentiation: review article. | 2004-07 |
|
| Controversies surrounding xanthine therapy. | 2004-06 |
|
| Differential influence of pentoxifylline on murine colon adenocarcinoma- and melanoma-derived metastatic tumor development in lungs. | 2004-05 |
|
| Pentoxifylline suppresses renal tumour necrosis factor-alpha and ameliorates experimental crescentic glomerulonephritis in rats. | 2004-05 |
|
| [Recommended therapy in chronic obstructive lung disease]. | 2004-04-04 |
|
| Effect of doxapram on cerebral blood flow velocity in preterm infants. | 2004-04 |
|
| Is there a place for N-acetylcysteine in the treatment of septic shock? | 2004-04 |
|
| The effect of drinking tea at high altitude on hydration status and mood. | 2004-04 |
|
| [Theophylline induces contractures in porcine skeletal muscle preparations with the disposition to malignant hyperthermia]. | 2004-03 |
|
| Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure. | 2004-03 |
|
| Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig. | 2004-02-25 |
|
| [Study of the cardiovascular properties of some new methyl-xanthine derivatives]. | 2004-02-06 |
|
| [Researches on methyl-xanthine series.XI. Synthesis and physicochemical characterization of some 7-R-1,3-dimethyl-xanthine derivatives]. | 2004-02-06 |
|
| The effects of intravenously administered methylxanthines on the proportion of goblet cells containing fucosylated glycoconjugates in rabbit tracheal epithelium. | 2004-02 |
|
| Insulin sensitivity of muscle capillary recruitment in vivo. | 2004-02 |
|
| Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. | 2004 |
|
| Redefining treatment in COPD: new directions in bronchodilator therapy. | 2004 |
|
| What interventions facilitate weaning from the ventilator? A review of the evidence from systematic reviews. | 2004 |
|
| [Controversies in the pharmacological management of acute asthma in children]. | 2003-12-17 |
|
| Effect of pentoxifylline on arachidonic acid metabolism, neutral lipid synthesis and accumulation during induction of the lipocyte phenotype by retinol in murine hepatic stellate cell. | 2003-12 |
|
| Guarana (Paullinia cupana Mart.) offers protection against gastric lesions induced by ethanol and indomethacin in rats. | 2003-12 |
|
| Pentoxifylline in the treatment of radiation-related pelvic insufficiency fractures of bone. | 2003-11-25 |
|
| Inhibition of DNA repair by Pentoxifylline and related methylxanthine derivatives. | 2003-11-15 |
|
| Pentoxifylline decreases tumor necrosis factor and interleukin-1 during high tidal volume. | 2003-10 |
|
| Study on inclusion complex of cyclodextrin with methyl xanthine derivatives by fluorimetry. | 2003-10 |
|
| Methylxanthines for exacerbations of chronic obstructive pulmonary disease: meta-analysis of randomised trials. | 2003-09-20 |
|
| Amelioration of B16F10 melanoma cells induced oxidative stress in DBA/2 mice by pentoxifylline. | 2003-09 |
|
| Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. | 2003-08-10 |
|
| Inhibition of TNF-alpha production by pentoxifylline does not prevent endotoxin-induced decrease in serum IGF-I. | 2003-07 |
|
| Pentoxifylline inhibits leukocyte infiltration and splenocyte cytotoxicity against murine colon adenocarcinoma. | 2003-06-07 |
|
| Preventive effect of pentoxifylline on renal scarring in rat model of pyelonephritis. | 2003-05 |
|
| Potentiation of lipid peroxidation in B16F10 and B16F1 melanoma cells by caffeine, a methylxanthine derivative: relationship to intracellular glutathione. | 2003-05 |
|
| Pathophysiology and management of neurocardiogenic syncope. | 2003-04 |
|
| Methylxanthines for exacerbations of chronic obstructive pulmonary disease. | 2003 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:22:00 GMT 2025
by
admin
on
Mon Mar 31 19:22:00 GMT 2025
|
| Record UNII |
13HCS9N24R
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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DTXSID40152592
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13HCS9N24R
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4917
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70975
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214-831-3
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1198-33-0
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