OXAZOLIDINE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H7NO
Molecular Weight	73.0938
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1COCN1

InChI

InChIKey=WYNCHZVNFNFDNH-UHFFFAOYSA-N

InChI=1S/C3H7NO/c1-2-5-3-4-1/h4H,1-3H2

HIDE SMILES / InChI

Molecular Formula	C3H7NO
Molecular Weight	73.0938
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22466369

Oxazolidine molecule consists of three carbons, nitrogen, and oxygen. Oxazolidines is a key molecular moiety in biologically active compounds. Some derivatives, the oxazolidinediones, are used as anticonvulsants.

Approval Year

PubMed

Title	Date	PubMed
Identification of the degradation pathways of alkanolamines with TiO2 photocatalysis.	2009-06-15	19013714
A general synthetic route to enantiopure 5-substituted cis-decahydroquinolines.	2009-02-20	19118477
The domino multicomponent allylation reaction for the stereoselective synthesis of homoallylic alcohols.	2009-02-17	19154154
Qualitative confirmation procedure for ephedrines as acetonide derivatives in doping urine samples by gas chromatography/electron ionization mass spectrometry.	2009-01	19072865
Diastereoselective synthesis of hexahydropyrrolo[2,1-b]oxazoles by a rhodium-catalyzed hydroformylation/silica-promoted deformylation sequence.	2009	19140145
Chiral, hemilabile palladium(II) complexes of tridentate oxazolidines, including C2-symmetric "pincers".	2008-11-17	18928277
Total synthesis of (+)-cassaine via transannular Diels-Alder reaction.	2008-10-22	18817389
Development of catalytic asymmetric 1,4-addition and [3 + 2] cycloaddition reactions using chiral calcium complexes.	2008-10-08	18783222
Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.	2008-10-01	18804380
A latent oxazoline electrophile for N-O-C bond formation in pseudomonine biosynthesis.	2008-09-17	18710233
Chiral pyranoside phosphite-oxazolines: a new class of ligand for asymmetric catalytic hydrogenation of alkenes.	2008-06-11	18481850
Narcolepsy: current treatment options and future approaches.	2008-06	18830438
Activation of N-sulfonyl oxaziridines using copper(II) catalysts: aminohydroxylations of styrenes and 1,3-dienes.	2008-05-21	18426204
Highly diastereoselective synthetic route to enantiopure beta(2)-amino acids and gamma-amino alcohols using a fluorinated oxazolidine (Fox) as chiral auxiliary.	2008-05-16	18419160
Evolution of the Petasis-Ferrier union/rearrangement tactic: construction of architecturally complex natural products possessing the ubiquitous cis-2,6-substituted tetrahydropyran structural element.	2008-05	18489082
Substituent effects on the ring-chain tautomerism of some 1,3-oxazolidine derivatives.	2008-05	18425798
Post-schiff base chemistry of the Maillard reaction: mechanism of imine isomerization.	2008-04	18448793
Chiral N-acyloxazolidines: synthesis, structure, and mechanistic insights.	2008-01-18	18092804
Fluorine... and pi...alkali metal interactions control in the stereoselective amide enolate alkylation with fluorinated oxazolidines (Fox) as a chiral auxiliary: an experimental and theoretical study.	2008	18283703
One-electron oxidation and reduction potentials of nitroxide antioxidants: a theoretical study.	2007-12-27	18052257
Developments in asymmetric catalysis by metal complexes of chiral chelating nitrogen-donor ligands.	2007-11-07	17940641
Conformational preferences of pseudoproline residues.	2007-11-01	17927239
Bisphosphine-catalyzed mixed double-Michael reactions: asymmetric synthesis of oxazolidines, thiazolidines, and pyrrolidines.	2007-10-31	17924625
Synthesis of new bisaryl cyclopentathiophene and thienocyclopentoxazolidine derivatives as potential cytotoxic agents.	2007-10	18035831
Hydroxyl-directed nitrile oxide cycloaddition reactions with cyclic allylic alcohols.	2007-09-13	17715933
Asymmetric synthesis of beta2-amino acids: 2-substituted-3-aminopropanoic acids from N-acryloyl SuperQuat derivatives.	2007-09-07	17700850
Antibacterial evaluations of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.	2007-09	17917239
Isolation and structure elucidation of thiazomycin- a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa.	2007-09	17917238
Effect of oxazolidine E on collagen fibril formation and stabilization of the collagen matrix.	2007-08-22	17649999
Kinetic and thermodynamic control of axial chirality in biaryl-derived fused oxazolidine lactams exploiting a centre-axis relay of unit efficiency.	2007-08-21	18019541
Enantioselective Friedel-Crafts alkylations catalyzed by bis(oxazolinyl)pyridine-scandium(III) triflate complexes.	2007-08-15	17658808
Synthesis of alpha- and beta-glycosyl isothiocyanates via oxazoline intermediates.	2007-06-08	17497800
2-alkenoyl pyridine N-oxides, highly efficient dienophiles for the enantioselective Cu(II)-bis(oxazoline) catalyzed Diels-Alder reaction.	2007-05-10	17447775
Unravelling the mechanism of the interactions of oxazolidine A and E with collagens in ovine skin.	2007-03-10	17055570
Copper(I)-catalyzed chlorine atom transfer radical cyclization reactions of unsaturated alpha-chloro beta-keto esters.	2006-12-07	17134265
Guanidinium ylide mediated aziridination: identification of a spiro imidazolidine-oxazolidine intermediate.	2006-08-18	16901150
Endohexosaminidase M: exploring and exploiting enzyme substrate specificity.	2006-08	16800015
Chemical C2-elongation of polyunsaturated fatty acids.	2006-06-29	17049508
Kinetic resolution of protected alpha-amino acid derivatives by a chiral O-nucleophilic acyl transfer catalyst.	2006-04-05	16568989
Impact of cis-proline analogs on peptide conformation.	2006-04-05	16358327
Structure-activity relationship of cyclic nitroxides as SOD mimics and scavengers of nitrogen dioxide and carbonate radicals.	2006-03-16	16526651
Convenient asymmetric synthesis of beta-trifluoromethyl-beta-amino acid, beta-amino ketones, and gamma-amino alcohols via Reformatsky and Mannich-type reactions from 2-trifluoromethyl-1,3-oxazolidines.	2006-03-03	16497009
Cyclic quaternary ammonium ionic liquids with perfluoroalkyltrifluoroborates: synthesis, characterization, and properties.	2006-03-01	16389616
Asymmetric hydrogenation of imines and olefins using phosphine-oxazoline iridium complexes as catalysts.	2006-03-01	16363009
Oxazolidin-2-one-containing pseudopeptides that fold into beta-bend ribbon spirals.	2006-02-22	16478196
Conformational arm-wrestling: battles for stereochemical control in benzamides bearing matched and mismatched chiral 2- and 6-substituents.	2006-02-07	16446801
Conformational preference in aromatic amides bearing chiral ortho substituents: its origin and application to relayed stereocontrol.	2006-02-07	16446800
The absolute configuration of (2S,4S)- and (2R,4R)-2-tert-butyl-4-methyl-3-(4-tolylsulfonyl)-1,3-oxazolidine-4-carbaldehyde.	2006-02	16456281
Investigation of 1,3-dipolar cycloaddition reactions of unsaturated nitrones in ionic liquids.	2006	16901818
Silylmethyl-substituted aziridine and azetidine as masked 1,3- and 1,4-dipoles for formal [3 + 2] and [4 + 2] cycloaddition reactions.	2005-11-30	16305202

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:06:03 GMT 2025` Edited by `admin` on `Mon Mar 31 19:06:03 GMT 2025`
Record UNII	13F52UF6MR
Record Status	`Validated (UNII)`
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OXAZOLIDINE

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OXAZOLIDINE