MANNOSULFAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H22O14S4
Molecular Weight	494.533
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(=O)(=O)OC[C@@H](OS(C)(=O)=O)[C@@H](O)[C@H](O)[C@@H](COS(C)(=O)=O)OS(C)(=O)=O

InChI

InChIKey=UUVIQYKKKBJYJT-ZYUZMQFOSA-N

InChI=1S/C10H22O14S4/c1-25(13,14)21-5-7(23-27(3,17)18)9(11)10(12)8(24-28(4,19)20)6-22-26(2,15)16/h7-12H,5-6H2,1-4H3/t7-,8-,9-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H22O14S4
Molecular Weight	494.533
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5093539 | Grumezescu, A.M. (2017) Nano- and Microscale Drug Delivery Systems, page 284, retrieved from: https://books.google.ru/books?id=WpIxDQAAQBAJ | Weber, G.F. (2015) Molecular Therapies of Cancer, page 35, retrieved from: https://books.google.ru/books?id=dhs_CgAAQBAJ

Mannosulfan is a typical example of the prototype drug busulfan. Mannosulfan, an alkyl sulfonate, produces inter- and intracross-links between DNA strands and ultimately leads to cell apoptosis. It has been used, mostly in Hungary, in the treatment of chronic myeloid leukemia and polycythemia vera.

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:59:18 GMT 2023` Edited by `admin` on `Fri Dec 15 16:59:18 GMT 2023`
Record UNII	135FQ40L36
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MANNOSULFAN

Official Name

English

Mannosulfan [WHO-DD]

Common Name

English

R-52

Code

English

D-MANNITOL 1,2,5,6-TETRAMETHANESULPHONATE

Common Name

English

D-MANNITOL 1,2,5,6-TETRAMETHANESULFONATE

Common Name

English

mannosulfan [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C222