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Details

Stereochemistry UNKNOWN
Molecular Formula C20H25FN4O
Molecular Weight 356.4371
Optical Activity ( + )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NIAPRAZINE, (+)-

SMILES

CC(CCN1CCN(CC1)C2=CC=C(F)C=C2)NC(=O)C3=CN=CC=C3

InChI

InChIKey=RSKQGBFMNPDPLR-UHFFFAOYSA-N
InChI=1S/C20H25FN4O/c1-16(23-20(26)17-3-2-9-22-15-17)8-10-24-11-13-25(14-12-24)19-6-4-18(21)5-7-19/h2-7,9,15-16H,8,10-14H2,1H3,(H,23,26)

HIDE SMILES / InChI

Molecular Formula C20H25FN4O
Molecular Weight 356.4371
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Niaprazine is a potent and selective antagonist of 5-HT2A and alpha-1 adrenergic receptors. It was used for the treatment of sleep disturbances in children and was investigated for the treatment of sleep disorders in patients with attention-deficit hyperactivity disorder and autistic disorder.

Approval Year

PubMed

PubMed

TitleDatePubMed
Insomnia in children: when are hypnotics indicated?
2002
Anxiolytics, hypnotics, and antidepressants dispensed to adolescents in a French region in 2002.
2006 Jul
Drug use in children: cohort study in three European countries.
2008 Nov 24
Niaprazine may improve some symptoms of attention-deficit hyperactivity disorder.
2010 Apr
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:18:21 GMT 2023
Edited
by admin
on Sat Dec 16 11:18:21 GMT 2023
Record UNII
1346Q758L9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NIAPRAZINE, (+)-
Common Name English
3-PYRIDINECARBOXAMIDE, N-(3-(4-(4-FLUOROPHENYL)-1-PIPERAZINYL)-1-METHYLPROPYL)-, (+)-
Systematic Name English
Code System Code Type Description
CAS
119306-37-5
Created by admin on Sat Dec 16 11:18:21 GMT 2023 , Edited by admin on Sat Dec 16 11:18:21 GMT 2023
PRIMARY
FDA UNII
1346Q758L9
Created by admin on Sat Dec 16 11:18:21 GMT 2023 , Edited by admin on Sat Dec 16 11:18:21 GMT 2023
PRIMARY
PUBCHEM
71919
Created by admin on Sat Dec 16 11:18:21 GMT 2023 , Edited by admin on Sat Dec 16 11:18:21 GMT 2023
PRIMARY
Related Record Type Details
RACEMATE -> ENANTIOMER