Details
Stereochemistry | UNKNOWN |
Molecular Formula | C20H25FN4O |
Molecular Weight | 356.4371 |
Optical Activity | ( + ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(CCN1CCN(CC1)C2=CC=C(F)C=C2)NC(=O)C3=CN=CC=C3
InChI
InChIKey=RSKQGBFMNPDPLR-UHFFFAOYSA-N
InChI=1S/C20H25FN4O/c1-16(23-20(26)17-3-2-9-22-15-17)8-10-24-11-13-25(14-12-24)19-6-4-18(21)5-7-19/h2-7,9,15-16H,8,10-14H2,1H3,(H,23,26)
Molecular Formula | C20H25FN4O |
Molecular Weight | 356.4371 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Niaprazine is a potent and selective antagonist of 5-HT2A and alpha-1 adrenergic receptors. It was used for the treatment of sleep disturbances in children and was investigated for the treatment of sleep disorders in patients with attention-deficit hyperactivity disorder and autistic disorder.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL231 |
|||
Target ID: CHEMBL2093870 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2853885 |
25.0 nM [Ki] | ||
Target ID: CHEMBL1907610 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2853885 |
77.0 nM [Ki] |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:18:21 GMT 2023
by
admin
on
Sat Dec 16 11:18:21 GMT 2023
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Record UNII |
1346Q758L9
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Record Status |
Validated (UNII)
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Record Version |
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119306-37-5
Created by
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1346Q758L9
Created by
admin on Sat Dec 16 11:18:21 GMT 2023 , Edited by admin on Sat Dec 16 11:18:21 GMT 2023
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71919
Created by
admin on Sat Dec 16 11:18:21 GMT 2023 , Edited by admin on Sat Dec 16 11:18:21 GMT 2023
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Related Record | Type | Details | ||
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RACEMATE -> ENANTIOMER |