INTEGRIN ALPHA-M

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:40:23 GMT 2025` Edited by `admin` on `Tue Apr 01 16:40:23 GMT 2025`
Protein Type	PEPTIDE
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	12YYA6IML4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CD11B

Preferred Name

English

INTEGRIN ALPHA-M

Common Name

English

ITGAM

Common Name

English

CELL SURFACE GLYCOPROTEIN MAC-1 SUBUNIT ALPHA

Common Name

English

NEUTROPHIL ADHERENCE RECEPTOR

Common Name

English

LEUKOCYTE ADHESION RECEPTOR MO1

Common Name

English

CR3A

Common Name

English

CD11 ANTIGEN-LIKE FAMILY MEMBER B

Common Name

English

CR-3 ALPHA CHAIN

Common Name

English

Code System Code Type Description

FDA UNII

12YYA6IML4

Created by admin on Tue Apr 01 16:40:23 GMT 2025 , Edited by admin on Tue Apr 01 16:40:23 GMT 2025

PRIMARY

PHAROS

P11215

Created by admin on Tue Apr 01 16:40:23 GMT 2025 , Edited by admin on Tue Apr 01 16:40:23 GMT 2025

PRIMARY

UNIPROT

P11215

Created by admin on Tue Apr 01 16:40:23 GMT 2025 , Edited by admin on Tue Apr 01 16:40:23 GMT 2025

PRIMARY

From	To
1_50	1_57
1_89	1_107
1_638	1_695
1_754	1_760
1_831	1_848
1_982	1_1006
1_1011	1_1016

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_70
N	1_224
N	1_375
N	1_453
N	1_676
N	1_680
N	1_718
N	1_785
N	1_864
N	1_884
N	1_895
N	1_924
N	1_930
N	1_962
N	1_977
N	1_1005
N	1_1028
N	1_1034
N	1_1059

Related Record Type Details


					HF23I3UYO2

GB-1275 FREE ACID

ACTIVATOR -> TARGET

Comments:

Allosteric modulator of CD11b, was shown to increase cell adhesion and reduce migration in vitro and effectively reduce macrophage and neutrophil migration in several animal models of inflammatory conditions.

Interaction Type:

ALLOSTERIC ACTIVATOR

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL